Search Results - "Garst, Michael"

Bimatoprost, Prostamide Activity, and Conventional Drainage by Wan, Zhou, Woodward, David F, Cornell, Clive L, Fliri, Hans G, Martos, Jose L, Pettit, Simon N, Wang, Jenny W, Kharlamb, Alexander B, Wheeler, Larry A, Garst, Michael E, Landsverk, Kari J, Struble, Craig S, Stamer, W. Daniel

“…Despite structural similarity with prostaglandin F(2 alpha), the ocular hypotensive agent bimatoprost (Lumigan; Allergan, Inc., Irvine, CA) shows unique…”
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1-Arylsulfonyl-2-(pyridylmethylsulfinyl) benzimidazoles as new proton pump inhibitor prodrugs by Shin, Jai Moo, Sachs, George, Cho, Young-moon, Garst, Michael

“…New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma…”
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A Convenient Synthesis of 7-Halo-1-indanones and 8-Halo-1-tetralones by Nguyen, Phong, Corpuz, Evelyn, Heidelbaugh, Todd M, Chow, Ken, Garst, Michael E

“…A regioselective oxidation of N-indan-4-yl-acetamide or N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetamide with potassium permanganate followed by acidic…”
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Studies of the Condensation of Sulfones with Ketones and Aldehydes by Garst, Michael E, Dolby, Lloyd J, Esfandiari, Shervin, Okrent, Rachel A, Avey, Alfred A

“…The condensation of ketones or aldehydes with sulfones was shown to give a variety of products. Condensation of 2-methylcyclohexanone with dimethyl sulfone…”
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Reductions with Lithium in Low Molecular Weight Amines and Ethylenediamine by Garst, Michael E, Dolby, Lloyd J, Esfandiari, Shervin, Fedoruk, N. Andrew, Chamberlain, Natalie C, Avey, Alfred A

“…Reductions of several types of compounds with lithium and ethylenediamine using low molecular weight amines as solvent are described. In all cases 1 mol of…”
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Synthesis and Evaluation of 2-(Arylamino)imidazoles as α2-Adrenergic Agonists by Munk, Stephen A, Harcourt, Dale A, Arasasingham, Premilla N, Burke, James A, Kharlamb, Alexander B, Manlapaz, Cynthia A, Padillo, Edwin U, Roberts, Donald, Runde, Eileen, Williams, Linda, Wheeler, Larry A, Garst, Michael E

“…A series of 2-(arylamino)imidazoles was synthesized and evaluated for activity at α1- and α2-adrenoceptors. This class of agents has been shown to have potent…”
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Synthesis and Structure−Activity Profiles of A-Homoestranes, the Estratropones by Miller, Thomas A, Bulman, Amanda L, Thompson, Charles D, Garst, Michael E, Macdonald, Timothy L

“…2-Methoxyestradiol, a mammalian metabolite of estradiol, has reported antiangiogenic activity which has been proposed to be mediated through interaction at the…”
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A new synthesis of substituted fulvenes by Lee, Gary C. M, Tobias, Brian, Holmes, Judy M, Harcourt, Dale A, Garst, Michael E

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Synthesis and Structure-Activity Relationships of Stilbene Retinoid Analogs Substituted with Heteroaromatic Carboxylic Acids by Beard, Richard L, Colon, Diana F, Gillett, Samuel J, Henry, Elizabeth, Marler, Deborah K, Song, Tae, Denys, Lydia, Garst, Michael E, Arefieg, Taghreed

“…Retinoids elicit biological responses by activating a series of nuclear receptors. Six retinoid receptors belonging to two families are currently known:…”
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Synthesis and Pharmacologic Evaluation of 2-endo-Amino-3-exo- isopropylbicyclo[2.2.1]heptane:  A Potent Imidazoline1 Receptor Specific Agent by Munk, Stephen A, Lai, Ronald K, Burke, James E, Arasasingham, Premilla N, Kharlamb, Alexander B, Manlapaz, Cynthia A, Padillo, Edwin U, Wijono, Mercy K, Hasson, Dain W, Wheeler, Larry A, Garst, Michael E

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Singlet oxygen oxidation of substituted furans to 5-hydroxy-2(5H)-furanone by Lee, Gary C. M, Syage, Elizabeth T, Harcourt, Dale A, Holmes, Judy M, Garst, Michael E

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Stereoselective synthesis and receptor activity of conformationally defined retinoid X receptor selective ligands by Vuligonda, Vidyasagar, Garst, Michael E., Chandraratna, Roshantha A.S.

“…Retinoid X Receptor (RXR) specific ligands are currently being investigated for the treatment of metabolic diseases such as type II diabetes. We report the…”
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Synthesis and Evaluation of 2-[(5-Methylbenz-1-ox-4-azin-6-yl)imino]imidazoline, a Potent, Peripherally Acting α2 Adrenoceptor Agonist by Munk, Stephen A, Harcourt, Dale, Ambrus, György, Denys, Lydia, Gluchowski, Charles, Burke, James A, Kharlamb, Alexander B, Manlapaz, Cynthia A, Padillo, Edwin U, Runde, Eileen, Williams, Linda, Wheeler, Larry A, Garst, Michael E

“…We have synthesized 2-[(5-methylbenz-1-ox-4-azin-6-yl)imino]imidazoline, 3, a potent, peripherally acting α2 adrenoceptor agonist. The agent is conveniently…”
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A Proposed Mechanism for p-Aminoclonidine Allergenicity Based on Its Relative Oxidative Lability by Thompson, Charles D, Vachaspati, Prakash R, Kolis, Stanley P, Gulden, Pamela H, Garst, Michael E, Wiese, Anne, Munk, Stephen A, Harman, W. Dean, Macdonald, Timothy L

“…p-Aminoclonidine (apraclonidine) is a selective α2 adrenergic agonist used to reduce intraocular pressure in the treatment of glaucoma. Use of apraclonidine is…”
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Effects of ascorbic acid in alkaptonuria: alterations in benzoquinone acetic acid and an ontogenic effect in infancy by WOLFF, J. A, BARSHOP, B, NYHAN, W. L, LESLIE, J, SEEGMILLER, J. E, GRUBER, H, GARST, M, WINTER, S, MICHALS, K, MATALON, R

“…The effects of ascorbic acid on the excretion of homogentisic acid and its derivative benzoquinone acetic acid were studied in two adults and three infants…”
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Flavin-containing monooxygenase S-oxygenation of a series of thioureas and thiones by Henderson, Marilyn C., Siddens, Lisbeth K., Krueger, Sharon K., Stevens, J. Fred, Kedzie, Karen, Fang, Wenkui K., Heidelbaugh, Todd, Nguyen, Phong, Chow, Ken, Garst, Michael, Gil, Daniel, Williams, David E.

“…Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and…”
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A general approach to 5-substitution of 3-furaldehydes by Lee, Gary C. M, Holmes, Judy M, Harcourt, Dale A, Garst, Michael E

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Synthesis and Carbonic Anhydrase Inhibitory Activity of 4-Substituted 2-Thiophenesulfonamides by Holmes, Judy M, Lee, Gary C. M, Wijono, Mercy, Weinkam, Robert, Wheeler, Larry A, Garst, Michael E

“…A series of 4-substituted 2-thiophenesulfonamides was prepared from 3-thiophenecarboxaldehyde using metalation chemistry developed for 3-furaldehyde. Several…”
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Cyclic sulfamate from N-substituted 2-amino-3-phenyl-1-propanol and its nucleophilic reactions [Erratum to document cited in CA114(19):185955d] by White, Gregory J, Garst, Michael E

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Preparation of hindered styrenes and arylacetylenes by Garst, Michael E, McBride, Bill J

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