Search Results - "Garscha, Ulrike"

Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products by Gilbert, Nathaniel C., Gerstmeier, Jana, Schexnaydre, Erin E., Börner, Friedemann, Garscha, Ulrike, Neau, David B., Werz, Oliver, Newcomer, Marcia E.

“…Leukotrienes (LT) are lipid mediators of the inflammatory response that are linked to asthma and atherosclerosis. LT biosynthesis is initiated by…”
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Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase by Pein, Helmut, Ville, Alexia, Pace, Simona, Temml, Veronika, Garscha, Ulrike, Raasch, Martin, Alsabil, Khaled, Viault, Guillaume, Dinh, Chau-Phi, Guilet, David, Troisi, Fabiana, Neukirch, Konstantin, König, Stefanie, Bilancia, Rosella, Waltenberger, Birgit, Stuppner, Hermann, Wallert, Maria, Lorkowski, Stefan, Weinigel, Christina, Rummler, Silke, Birringer, Marc, Roviezzo, Fiorentina, Sautebin, Lidia, Helesbeux, Jean-Jacques, Séraphin, Denis, Mosig, Alexander S., Schuster, Daniela, Rossi, Antonietta, Richomme, Pascal, Werz, Oliver, Koeberle, Andreas

“…Systemic vitamin E metabolites have been proposed as signaling molecules, but their physiological role is unknown. Here we show, by library screening of…”
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Platelet-Derived S1P and Its Relevance for the Communication with Immune Cells in Multiple Human Diseases by Tolksdorf, Céline, Moritz, Eileen, Wolf, Robert, Meyer, Ulrike, Marx, Sascha, Bien-Möller, Sandra, Garscha, Ulrike, Jedlitschky, Gabriele, Rauch, Bernhard H.

“…Sphingosine-1-phosphate (S1P) is a versatile signaling lipid involved in the regulation of numerous cellular processes. S1P regulates cellular proliferation,…”
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Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A4 Hydrolase by Teder, Tarvi, König, Stefanie, Singh, Rajkumar, Samuelsson, Bengt, Werz, Oliver, Garscha, Ulrike, Haeggström, Jesper Z.

“…The 5-lipoxygenase (5-LOX) pathway gives rise to bioactive inflammatory lipid mediators, such as leukotrienes (LTs). 5-LOX carries out the oxygenation of…”
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Enhanced platelet sensitization is accompanied by increased expression of the transporter MRP4 and elevated plasma S1P levels in mild COVID-19 convalescents by Tolksdorf, Céline, Seidel, Andrea, Baume, Christian, Moritz, Eileen, Saljé, Karen, Lehmann, Kathrin, Becker, Karsten, Garscha, Ulrike, Thiele, Thomas, Schwedhelm, Edzard, von Lucadou, Mirjam, Tzvetkov, Mladen V, Engeli, Stefan, Jedlitschky, Gabriele, Rauch, Bernhard H

“…Viral infections can lead to platelet activation and hemostatic complications. However, the extent to which platelet reactivity remains altered after…”
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Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction by Mayr, Fabian, Möller, Gabriele, Garscha, Ulrike, Fischer, Jana, Rodríguez Castaño, Patricia, Inderbinen, Silvia G, Temml, Veronika, Waltenberger, Birgit, Schwaiger, Stefan, Hartmann, Rolf W, Gege, Christian, Martens, Stefan, Odermatt, Alex, Pandey, Amit V, Werz, Oliver, Adamski, Jerzy, Stuppner, Hermann, Schuster, Daniela

“…Natural products comprise a rich reservoir for innovative drug leads and are a constant source of bioactive compounds. To find pharmacological targets for new…”
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Synthesis and structure-activity relationships for some novel diflapolin derivatives with benzimidazole subunit by Vieider, Lisa, Zoeller, Eva, Romp, Erik, Schoenthaler, Martin, Hernández-Olmos, Victor, Temml, Veronika, Hasenoehrl, Thomas, Schuster, Daniela, Werz, Oliver, Garscha, Ulrike, Matuszczak, Barbara

“…A series of derivatives of the potent dual soluble epoxide hydrolase (sEH)/5-lipoxygenase-activating protein (FLAP) inhibitor diflapolin was designed,…”
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Development of SFC-MS Method for Quantification of Eicosanoids Biosynthesized in Primary Human Blood Cells by Schmidt, Louis, Burmeister, Laura Sophie, Greinacher, Andreas, König, Stefanie, Garscha, Ulrike

“…Eicosanoids are lipid mediators generated from arachidonic acid with pro- and anti-inflammatory properties. Despite these lipid mediators being known for…”
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Enantiomeric separation and analysis of unsaturated hydroperoxy fatty acids by chiral column chromatography-mass spectrometry by Garscha, Ulrike, Nilsson, Tomas, Oliw, Ernst H.

“…Hydroperoxides of 18:2n-6 and 20:4n-6 were obtained by autoxidation and photooxidation. The enantiomers were separated as free acids (Reprosil Chiral-NR…”
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Evaluation of Dual 5‑Lipoxygenase/Microsomal Prostaglandin E2 Synthase‑1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones by Svouraki, Alexandra, Garscha, Ulrike, Kouloura, Eirini, Pace, Simona, Pergola, Carlo, Krauth, Verena, Rossi, Antonietta, Sautebin, Lidia, Halabalaki, Maria, Werz, Oliver, Gaboriaud-Kolar, Nicolas, Skaltsounis, Alexios-Leandros

“…Among the pathways responsible for the development of inflammatory responses, the cyclooxygenase and lipoxygenase pathways are among the most important ones…”
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A procedure for efficient non-viral siRNA transfection of primary human monocytes using nucleofection by Scherer, Olga, Maeß, Marten B., Lindner, Saskia, Garscha, Ulrike, Weinigel, Christina, Rummler, Silke, Werz, Oliver, Lorkowski, Stefan

“…Monocytes are an important constituent of the innate immune system. Therefore, manipulating gene expression of primary human monocytes is a crucial mean to…”
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Stereoselective oxidation of regioisomeric octadecenoic acids by fatty acid dioxygenases by Oliw, Ernst H., Wennman, Anneli, Hoffmann, Inga, Garscha, Ulrike, Hamberg, Mats, Jernerén, Fredrik

“…Seven Z-octadecenoic acids having the double bond located in positions 6Z to 13Z were photooxidized. The resulting hydroperoxy-E-octadecenoic acids [HpOME(E)]…”
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Leucine/Valine Residues Direct Oxygenation of Linoleic Acid by (10R)- and (8R)-Dioxygenases by Garscha, Ulrike, Oliw, Ernst H.

“…Linoleate (10R)-dioxygenase (10R-DOX) of Aspergillus fumigatus was cloned and expressed in insect cells. Recombinant 10R-DOX oxidized 18:2n-6 to…”
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Pichia expression and mutagenesis of 7,8-linoleate diol synthase change the dioxygenase and hydroperoxide isomerase by Garscha, Ulrike, Oliw, Ernst

“…Linoleate diol synthases (LDS) are homologous 8(R)-dioxygenases with hydroperoxide isomerase activities, expressed in fungal pathogens of humanitarian…”
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Identification of Dioxygenases Required for Aspergillus Development by Garscha, Ulrike, Jernerén, Fredrik, Chung, DaWoon, Keller, Nancy P., Hamberg, Mats, Oliw, Ernst H.

“…Aspergillus sp. contain ppoA, ppoB, and ppoC genes, which code for fatty acid oxygenases with homology to fungal linoleate 7,8-diol synthases (7,8-LDS) and…”
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Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents by Werz, Oliver, Gerstmeier, Jana, Garscha, Ulrike

“…Leukotrienes (LTs) are lipid mediators produced from arachidonic acid with a broad variety of bioactivities in allergy and inflammation. The biosynthesis of…”
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Steric analysis of 8-hydroxy- and 10-hydroxyoctadecadienoic acids and dihydroxyoctadecadienoic acids formed from 8R-hydroperoxyoctadecadienoic acid by hydroperoxide isomerases by Garscha, Ulrike, Oliw, Ernst H.

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Hyphal‐associated protein expression is crucial for Candida albicans‐induced eicosanoid biosynthesis in immune cells by Schimanski, Jana, Gresnigt, Mark S., Brunner, Elena, Werz, Oliver, Hube, Bernhard, Garscha, Ulrike

“…Candida albicans causes opportunistic infections ranging from mucosal mycoses to life‐threatening systemic infections in immunocompromised patients. During C…”
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Candida albicans‐induced leukotriene biosynthesis in neutrophils is restricted to the hyphal morphology by Fischer, Jana, Gresnigt, Mark S., Werz, Oliver, Hube, Bernhard, Garscha, Ulrike

“…Neutrophils are the most abundant leukocytes in circulation playing a key role in acute inflammation during microbial infections. Phagocytosis, one of the…”
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Can transcutaneous auricular vagus nerve stimulation mitigate vigilance loss? Examining the effects of stimulation at individualized versus constant current intensity by Luna, Fernando G, Lupiáñez, Juan, König, Stefanie, Garscha, Ulrike, Fischer, Rico

“…According to the arousal model of vigilance, the locus coeruleus-norepinephrine (LC-NE) system modulates sustained attention over long periods by regulating…”
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