Search Results - "Garry, R"

Cystic fibrosis genetics: from molecular understanding to clinical application by Cutting, Garry R.

“…Key Points Investigation of disease-causing variants such as F508del is resolving the mechanisms underlying cystic fibrosis transmembrane conductance regulator…”
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Modifier genes in Mendelian disorders: the example of cystic fibrosis by Cutting, Garry R.

“…In the past three decades, scientists have had immense success in identifying genes and their variants that contribute to an array of diseases. While the…”
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Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide by Buettner, Garry R

“…Superoxide dismutases (SOD) are considered to be antioxidant enzymes. This view came about because its substrate, superoxide, is a free radical; in the era of…”
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Ascorbic acid: Chemistry, biology and the treatment of cancer by Du, Juan, Cullen, Joseph J., Buettner, Garry R.

“…Since the discovery of vitamin C, the number of its known biological functions is continually expanding. Both the names ascorbic acid and vitamin C reflect its…”
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Thermodynamic and kinetic considerations for the reaction of semiquinone radicals to form superoxide and hydrogen peroxide by Song, Yang, Buettner, Garry R.

“…The quinone/semiquinone/hydroquinone triad (Q/SQ •−/H 2Q) represents a class of compounds that has great importance in a wide range of biological processes…”
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In Memoriam: Haig H. Kazazian, Jr. (1937–2022) by Cutting, Garry R.

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An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses by Spitz, Douglas R., Buettner, Garry R., Petronek, Michael S., St-Aubin, Joël J., Flynn, Ryan T., Waldron, Timothy J., Limoli, Charles L.

“…•FLASH radiation dose-rates consume all the local tissue O2 to form reactive organic hydroperoxides.•Fenton type reactions will be limited in normal vs. cancer…”
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Larval Export from Marine Reserves and the Recruitment Benefit for Fish and Fisheries by Harrison, Hugo B., Williamson, David H., Evans, Richard D., Almany, Glenn R., Thorrold, Simon R., Russ, Garry R., Feldheim, Kevin A., van Herwerden, Lynne, Planes, Serge, Srinivasan, Maya, Berumen, Michael L., Jones, Geoffrey P.

“…Marine reserves, areas closed to all forms of fishing, continue to be advocated and implemented to supplement fisheries and conserve populations [1–4]…”
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The rate of oxygen utilization by cells by Wagner, Brett A., Venkataraman, Sujatha, Buettner, Garry R.

“…The discovery of oxygen is considered by some to be the most important scientific discovery of all time—from both physical–chemical/astrophysics and…”
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Laparoscopic morcellation: an acceptable risk or an Achilles heel? by Garry, R

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From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations by Veit, Gudio, Avramescu, Radu G, Chiang, Annette N, Houck, Scott A, Cai, Zhiwei, Peters, Kathryn W, Hong, Jeong S, Pollard, Harvey B, Guggino, William B, Balch, William E, Skach, William R, Cutting, Garry R, Frizzell, Raymond A, Sheppard, David N, Cyr, Douglas M, Sorscher, Eric J, Brodsky, Jeffrey L, Lukacs, Gergely L

“…More than 2000 mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) have been described that confer a range of molecular cell biological…”
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Positive QRS complex in limb lead 2 with negative QRS in lead 3 on surface electrocardiogram is not indicative of a right sided accessory pathway by Kumar, Sharath, Thomas, Garry R.

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Treating Specific Variants Causing Cystic Fibrosis by Cutting, Garry R

“…Many chronic diseases are caused by abnormal function oil or more proteins. Knowing which proteins and what precipitating factors (eg, toxins, inhibitors,…”
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Moving free radical and redox biology ahead in the next decade(s) by Buettner, Garry R.

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Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy by Doskey, Claire M., Buranasudja, Visarut, Wagner, Brett A., Wilkes, Justin G., Du, Juan, Cullen, Joseph J., Buettner, Garry R.

“…Ascorbate (AscH − ) functions as a versatile reducing agent. At pharmacological doses (P-AscH − ; [plasma AscH − ] ≥≈20 mM), achievable through intravenous…”
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Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework by Brnich, Sarah E, Abou Tayoun, Ahmad N, Couch, Fergus J, Cutting, Garry R, Greenblatt, Marc S, Heinen, Christopher D, Kanavy, Dona M, Luo, Xi, McNulty, Shannon M, Starita, Lea M, Tavtigian, Sean V, Wright, Matt W, Harrison, Steven M, Biesecker, Leslie G, Berg, Jonathan S

“…The American College of Medical Genetics and Genomics (ACMG)/Association for Molecular Pathology (AMP) clinical variant interpretation guidelines established…”
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Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene by Sosnay, Patrick R, Siklosi, Karen R, Van Goor, Fredrick, Kaniecki, Kyle, Yu, Haihui, Sharma, Neeraj, Ramalho, Anabela S, Amaral, Margarida D, Dorfman, Ruslan, Zielenski, Julian, Masica, David L, Karchin, Rachel, Millen, Linda, Thomas, Philip J, Patrinos, George P, Corey, Mary, Lewis, Michelle H, Rommens, Johanna M, Castellani, Carlo, Penland, Christopher M, Cutting, Garry R

“…Garry Cutting and colleagues report a comprehensive functional and clinical analysis of CFTR variants reported in cystic fibrosis. They determine that 128 of…”
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Coral cover a stronger driver of reef fish trophic biomass than fishing by Russ, Garry R., Rizzari, Justin R., Abesamis, Rene A., Alcala, Angel C.

“…An influential paradigm in coral reef ecology is that fishing causes trophic cascades through reef fish assemblages, resulting in reduced herbivory and thus…”
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Metal organic framework-mediated synthesis of highly active and stable Fischer-Tropsch catalysts by Santos, Vera P., Wezendonk, Tim A., Jaén, Juan José Delgado, Dugulan, A. Iulian, Nasalevich, Maxim A., Islam, Husn-Ubayda, Chojecki, Adam, Sartipi, Sina, Sun, Xiaohui, Hakeem, Abrar A., Koeken, Ard C.J., Ruitenbeek, Matthijs, Davidian, Thomas, Meima, Garry R., Sankar, Gopinathan, Kapteijn, Freek, Makkee, Michiel, Gascon, Jorge

“…Depletion of crude oil resources and environmental concerns have driven a worldwide research on alternative processes for the production of commodity…”
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A wearable potentiometric sensor with integrated salt bridge for sweat chloride measurement by Choi, Dong-Hoon, Li, Yi, Cutting, Garry R., Searson, Peter C.

“…[Display omitted] •We have developed a wearable potentiometric chloride sweat sensor with integrated salt bridge to minimize equilibration.•We show an accuracy…”
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