Search Results - "Garruss, Alexander S"

The RNA Pol II Elongation Factor Ell3 Marks Enhancers in ES Cells and Primes Future Gene Activation by Lin, Chengqi, Garruss, Alexander S., Luo, Zhuojuan, Guo, Fengli, Shilatifard, Ali

“…Enhancers play a central role in precisely regulating the expression of developmentally regulated genes. However, the machineries required for…”
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A deep learning approach to programmable RNA switches by Angenent-Mari, Nicolaas M., Garruss, Alexander S., Soenksen, Luis R., Church, George, Collins, James J.

“…Engineered RNA elements are programmable tools capable of detecting small molecules, proteins, and nucleic acids. Predicting the behavior of these synthetic…”
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Engineering an allosteric transcription factor to respond to new ligands by Taylor, Noah D, Garruss, Alexander S, Moretti, Rocco, Chan, Sum, Arbing, Mark A, Cascio, Duilio, Rogers, Jameson K, Isaacs, Farren J, Kosuri, Sriram, Baker, David, Fields, Stanley, Church, George M, Raman, Srivatsan

“…The combination of computational protein design and single-site saturation mutagenesis enables engineering of allosteric transcription factors to respond to…”
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Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4 by Herz, Hans-Martin, Mohan, Man, Garruss, Alexander S, Liang, Kaiwei, Takahashi, Yoh-Hei, Mickey, Kristen, Voets, Olaf, Verrijzer, C Peter, Shilatifard, Ali

“…Monomethylation of histone H3 on Lys 4 (H3K4me1) and acetylation of histone H3 on Lys 27 (H3K27ac) are histone modifications that are highly enriched over the…”
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The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells by Hu, Deqing, Garruss, Alexander S, Gao, Xin, Morgan, Marc A, Cook, Malcolm, Smith, Edwin R, Shilatifard, Ali

“…Embryonic stem cells (ESCs) possess a unique chromatin landscape in which 'bivalent' domains of trimethylated histone H3 Lys4 (H3K4me3) and Lys27 (H3K27me3)…”
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The Little Elongation Complex Functions at Initiation and Elongation Phases of snRNA Gene Transcription by Hu, Deqing, Smith, Edwin R., Garruss, Alexander S., Mohaghegh, Nima, Varberg, Joseph M., Lin, Chengqi, Jackson, Jessica, Gao, Xin, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Eissenberg, Joel C., Shilatifard, Ali

“…The small nuclear RNA (snRNA) genes have been widely used as a model system for understanding transcriptional regulation due to the unique aspects of their…”
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Poised RNA Polymerase II Changes over Developmental Time and Prepares Genes for Future Expression by Gaertner, Bjoern, Johnston, Jeff, Chen, Kai, Wallaschek, Nina, Paulson, Ariel, Garruss, Alexander S., Gaudenz, Karin, De Kumar, Bony, Krumlauf, Robb, Zeitlinger, Julia

“…Poised RNA polymerase II (Pol II) is predominantly found at developmental control genes and is thought to allow their rapid and synchronous induction in…”
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Divergence of transcriptional landscape occurs early in B cell activation by Fowler, Trent, Garruss, Alexander S, Ghosh, Amalendu, De, Supriyo, Becker, Kevin G, Wood, William H, Weirauch, Matthew T, Smale, Stephen T, Aronow, Bruce, Sen, Ranjan, Roy, Ananda L

“…Signaling via B cell receptor (BCR) and Toll-like receptors (TLRs) results in activation of B cells with distinct physiological outcomes, but transcriptional…”
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Dataset of transcriptional landscape of B cell early activation by Garruss, Alexander S., Fowler, Trent

“…Signaling via B cell receptors (BCR) and Toll-like receptors (TLRs) result in activation of B cells with distinct physiological outcomes, but transcriptional…”
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Deep representation learning improves prediction of LacI-mediated transcriptional repression by Garruss, Alexander S., Collins, Katherine M., Church, George M.

“…Recent progress in DNA synthesis and sequencing technology has enabled systematic studies of protein function at a massive scale. We explore a deep mutational…”
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Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution by Smith, Jeramiah J, Kuraku, Shigehiro, Holt, Carson, Sauka-Spengler, Tatjana, Jiang, Ning, Campbell, Michael S, Yandell, Mark D, Manousaki, Tereza, Meyer, Axel, Bloom, Ona E, Morgan, Jennifer R, Buxbaum, Joseph D, Sachidanandam, Ravi, Sims, Carrie, Garruss, Alexander S, Cook, Malcolm, Krumlauf, Robb, Wiedemann, Leanne M, Sower, Stacia A, Decatur, Wayne A, Hall, Jeffrey A, Amemiya, Chris T, Saha, Nil R, Buckley, Katherine M, Rast, Jonathan P, Das, Sabyasachi, Hirano, Masayuki, McCurley, Nathanael, Guo, Peng, Rohner, Nicolas, Tabin, Clifford J, Piccinelli, Paul, Elgar, Greg, Ruffier, Magali, Aken, Bronwen L, Searle, Stephen M J, Muffato, Matthieu, Pignatelli, Miguel, Herrero, Javier, Jones, Matthew, Brown, C Titus, Chung-Davidson, Yu-Wen, Nanlohy, Kaben G, Libants, Scot V, Yeh, Chu-Yin, McCauley, David W, Langeland, James A, Pancer, Zeev, Fritzsch, Bernd, de Jong, Pieter J, Zhu, Baoli, Fulton, Lucinda L, Theising, Brenda, Flicek, Paul, Bronner, Marianne E, Warren, Wesley C, Clifton, Sandra W, Wilson, Richard K, Li, Weiming

“…Jeramiah Smith, Weiming Li and colleagues report the whole-genome sequence of the sea lamprey, Petromyzon marinus , representing a vertebrate lineage diverged…”
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An unbiased index to quantify participant’s phenotypic contribution to an open-access cohort by Chan, Yingleong, Tung, Michael, Garruss, Alexander S., Zaranek, Sarah W., Chan, Ying Kai, Lunshof, Jeantine E., Zaranek, Alexander W., Ball, Madeleine P., Chou, Michael F., Lim, Elaine T., Church, George M.

“…The Personal Genome Project (PGP) is an effort to enroll many participants to create an open-access repository of genome, health and trait data for research…”
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Deep representation learning improves prediction of LacI-mediated transcriptional repression by Garruss, Alexander S., Collins, Katherine M., Church, George M.

“…Significance The understanding of protein function increases with new experimental and evolutionary datasets. A major challenge is to apply machine learning to…”
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