Search Results - "Garrow, Timothy A"

Betaine-Homocysteine S-Methyltransferase-2 Is an S-Methylmethionine-Homocysteine Methyltransferase by Szegedi, Sandra S., Castro, Carmen C., Koutmos, Markos, Garrow, Timothy A.

“…We demonstrate that purified recombinant human betainehomocysteine methyltransferase-2 (BHMT-2) is a zinc metalloenzyme that uses S-methylmethionine (SMM) as a…”
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Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes by Ganu, Radhika S, Ishida, Yasuko, Koutmos, Markos, Kolokotronis, Sergios-Orestis, Roca, Alfred L, Garrow, Timothy A, Schook, Lawrence B

“…Betaine-homocysteine S-methyltransferase (BHMT) and BHMT2 convert homocysteine to methionine using betaine and S-methylmethionine, respectively, as methyl…”
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Folate Deficiency Disturbs Hepatic Methionine Metabolism and Promotes Liver Injury in the Ethanol-Fed Micropig by Halsted, Charles H., Villanueva, Jesus A., Devlin, Angela M., Niemelä, Onni, Parkkila, Seppo, Garrow, Timothy A., Wallock, Lynn M., Shigenaga, Mark K., Melnyk, Stepan, James, S. Jill

“…Alcoholic liver disease is associated with abnormal hepatic methionine metabolism and folate deficiency. Because folate is integral to the methionine cycle,…”
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Deletion of Betaine-Homocysteine S-Methyltransferase in Mice Perturbs Choline and 1-Carbon Metabolism, Resulting in Fatty Liver and Hepatocellular Carcinomas by Teng, Ya-Wen, Mehedint, Mihai G., Garrow, Timothy A., Zeisel, Steven H.

“…Betaine-homocysteine S-methyltransferase (BHMT) uses betaine to catalyze the conversion of homocysteine (Hcy) to methionine. There are common genetic…”
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Hepatic Activity and Transcription of Betaine-Homocysteine Methyltransferase, Methionine Synthase, and Cystathionine Synthase in Periparturient Dairy Cows Are Altered to Different Extents by Supply of Methionine and Choline by Zhou, Zheng, Garrow, Timothy A, Dong, Xianwen, Luchini, Daniel N, Loor, Juan J

“…Compared with choline, Met enhances milk yield and feed intake, and elicits a better immuno-metabolic status in periparturient cows. It is unknown whether…”
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Modulation of Methyl Group Metabolism by Streptozotocin-induced Diabetes and All-trans-retinoic Acid by Nieman, Kristin M, Rowling, Matthew J, Garrow, Timothy A, Schalinske, Kevin L

“…The hepatic enzyme glycine N -methyltransferase (GNMT) plays a major role in the control of methyl group and homocysteine metabolism. Because disruption of…”
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Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro by Miller, Catherine M, Szegedi, Sandra S, Garrow, Timothy A

“…Betaine-homocysteine S-methyltransferase (BHMT) transfers a methyl group from betaine to Hcy to form DMG (dimethylglycine) and Met. The reaction is ordered Bi…”
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Type I diabetes leads to tissue-specific DNA hypomethylation in male rats by Williams, Kelly T, Garrow, Timothy A, Schalinske, Kevin L

“…Numerous perturbations of methyl group and homocysteine metabolism have been documented as an outcome of diabetes. It has also been observed that there is a…”
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Betaine Homocysteine Methyltransferase Is Active in the Mouse Blastocyst and Promotes Inner Cell Mass Development by Lee, Martin B., Kooistra, Megan, Zhang, Baohua, Slow, Sandy, Fortier, Amanda L., Garrow, Timothy A., Lever, Michael, Trasler, Jacquetta M., Baltz, Jay M.

“…Methyltransferases are an important group of enzymes with diverse roles that include epigenetic gene regulation. The universal donor of methyl groups for…”
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Betaine can partially spare choline in chicks but only when added to diets containing a minimal level of choline by Dilger, Ryan N, Garrow, Timothy A, Baker, David H

“…The ability of betaine to serve as a methyl donor in chicks was assessed in 3 bioassays using a choline-free purified diet that contained adequate methionine…”
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Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats by Slow, Sandy, Garrow, Timothy A

“…Choline dehydrogenase (CHDH) and betaine-homocysteine methyltransferase (BHMT) are 2 enzymes involved in choline oxidation. BHMT is expressed at high levels in…”
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Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice by Collinsova, Michaela, Strakova, Jana, Jiracek, Jiri, Garrow, Timothy A

“…Inhibitors and methyl donor substrates for betaine-homocysteine S-methyltransferase (BHMT) were used to study the role of this enzyme in the regulation of…”
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Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase by Mládková, Jana, Hladílková, Jana, Diamond, Carrie E., Tryon, Katherine, Yamada, Kazuhiro, Garrow, Timothy A., Jungwirth, Pavel, Koutmos, Markos, Jiráček, Jiří

“…ABSTRACT Betaine‐homocysteine S‐methyltransferase (BHMT) is a zinc‐dependent methyltransferase that uses betaine as the methyl donor for the remethylation of…”
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The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase by Pícha, Jan, Vaněk, Václav, Buděšínský, Miloš, Mládková, Jana, Garrow, Timothy A., Jiráček, Jiří

“…Betaine-homocysteine S-methyltransferase (BHMT) is an important zinc-dependent methyltransferase that uses betaine as the methyl donor for the remethylation of…”
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Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc by Castro, Carmen, Millian, Norman S., Garrow, Timothy A.

“…Using a redox-inert methyl acceptor, we show that betaine-homocysteine S-methyltransferase (BHMT) requires a thiol reducing agent for activity. Short-term…”
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Inhibition of betaine-homocysteine S -methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β -synthase activity and methylation capacity by Strakova, Jana, Gupta, Sapna, Kruger, Warren D, Dilger, Ryan N, Tryon, Katherine, Li, Lucas, Garrow, Timothy A

“…Abstract Methylation of homocysteine (Hcy) by betaine-Hcy S -methyltransferase (BHMT) produces methionine, which is required for S -adenosylmethionine (SAM)…”
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Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver by Ratnam, Shobhitha, Wijekoon, Enoka P, Hall, Beatrice, Garrow, Timothy A, Brosnan, Margaret E, Brosnan, John T

“…Elevation of plasma homocysteine levels has been recognized as an independent risk factor for the development of cardiovascular disease, a major complication…”
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Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes by Ganu, Radhika S., Garrow, Timothy A., Sodhi, Monika, Rund, Laurie A., Schook, Lawrence B.

“…Betaine homocysteine methyltransferase (BHMT) and BHMT-2 enzymes methylate homocysteine to form methionine using betaine and S-methylmethionine, respectively…”
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Correction to Double-Headed Sulfur-Linked Amino Acids As First Inhibitors for Betaine-Homocysteine S‑Methyltransferase 2 by Mládková, Jana, Vaněk, Václav, Buděšínský, Miloš, Elbert, Tomáš, Demianová, Zuzana, Garrow, Timothy A, Jiráček, Jiří

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Double-Headed Sulfur-Linked Amino Acids As First Inhibitors for Betaine-Homocysteine S-Methyltransferase 2 by Mládková, Jana, Vaněk, Václav, Buděšínský, Miloš, Elbert, Tomáš, Demianová, Zuzana, Garrow, Timothy A, Jiráček, Jiří

“…Betaine-homocysteine S-methyltransferase 2 (BHMT-2) catalyzes the transfer of a methyl group from S-methylmethionine to l-homocysteine, yielding two molecules…”
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