Search Results - "Garrison, Brian S"

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging by Beerman, Isabel, Bock, Christoph, Garrison, Brian S., Smith, Zachary D., Gu, Hongcang, Meissner, Alexander, Rossi, Derrick J.

“…The functional potential of hematopoietic stem cells (HSCs) declines during aging, and in doing so, significantly contributes to hematopoietic pathophysiology…”
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Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9 by Mandal, Pankaj K., Ferreira, Leonardo M.R., Collins, Ryan, Meissner, Torsten B., Boutwell, Christian L., Friesen, Max, Vrbanac, Vladimir, Garrison, Brian S., Stortchevoi, Alexei, Bryder, David, Musunuru, Kiran, Brand, Harrison, Tager, Andrew M., Allen, Todd M., Talkowski, Michael E., Rossi, Derrick J., Cowan, Chad A.

“…Genome editing via CRISPR/Cas9 has rapidly become the tool of choice by virtue of its efficacy and ease of use. However, CRISPR/Cas9-mediated genome editing in…”
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Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors by Riddell, Jonah, Gazit, Roi, Garrison, Brian S., Guo, Guoji, Saadatpour, Assieh, Mandal, Pankaj K., Ebina, Wataru, Volchkov, Pavel, Yuan, Guo-Cheng, Orkin, Stuart H., Rossi, Derrick J.

“…Hematopoietic stem cells (HSCs) sustain blood formation throughout life and are the functional units of bone marrow transplantation. We show that transient…”
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Precision off-the-shelf natural killer cell therapies for oncology with logic-gated gene circuits by Frankel, Nicholas W., Deng, Han, Yucel, Gozde, Gainer, Marcus, Leemans, Nelia, Lam, Alice, Li, Yongshuai, Hung, Michelle, Lee, Derrick, Lee, Chen-Ting, Banicki, Andrew, Tian, Mengxi, Almudhfar, Niran, Naitmazi, Lawrence, Roguev, Assen, Lee, Seunghee, Wong, Wilson, Gordley, Russell, Lu, Timothy K., Garrison, Brian S.

“…Acute myeloid leukemia (AML) is an aggressive disease with a poor prognosis (5-year survival rate of 30.5% in the United States). Designing cell therapies to…”
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ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells by Garrison, Brian S., Rybak, Adrian P., Beerman, Isabel, Heesters, Balthasar, Mercier, Francois E., Scadden, David T., Bryder, David, Baron, Roland, Rossi, Derrick J.

“…The concept that tumor-initiating cells can co-opt the self-renewal program of endogenous stem cells as a means of enforcing their unlimited proliferative…”
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Transcriptome analysis identifies regulators of hematopoietic stem and progenitor cells by Gazit, Roi, Garrison, Brian S, Rao, Tata Nageswara, Shay, Tal, Costello, James, Ericson, Jeff, Kim, Francis, Collins, James J, Regev, Aviv, Wagers, Amy J, Rossi, Derrick J

“…Hematopoietic stem cells (HSCs) maintain blood homeostasis and are the functional units of bone marrow transplantation. To improve the molecular understanding…”
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Postintegrative Gene Silencing within the Sleeping Beauty Transposition System by Garrison, Brian S., Yant, Stephen R., Mikkelsen, Jacob Giehm, Kay, Mark A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Reactive Oxygen Species Resulting from Mitochondrial Mutation Diminishes Stem and Progenitor Cell Function by Garrison, Brian S., Rossi, Derrick J.

“…While age-dependent stem cell decline is widely recognized as being a key component of organismal aging, the underlying mechanisms remain elusive. In this…”
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A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System by Qin, Yan, Garrison, Brian S., Ma, Wenjiang, Wang, Rui, Jiang, Aiping, Li, Jing, Mistry, Meeta, Bronson, Roderick T., Santoro, Daria, Franco, Charlotte, Robinton, Daisy A., Stevens, Beth, Rossi, Derrick J., Lu, Chafen, Springer, Timothy A.

“…Extracellular proTGF-β is covalently linked to “milieu” molecules in the matrix or on cell surfaces and is latent until TGF-β is released by integrins. Here,…”
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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages by Gautier, Emmanuel L, Shay, Tal, Miller, Jennifer, Greter, Melanie, Jakubzick, Claudia, Ivanov, Stoyan, Helft, Julie, Chow, Andrew, Elpek, Kutlu G, Gordonov, Simon, Mazloom, Amin R, Ma'ayan, Avi, Chua, Wei-Jen, Hansen, Ted H, Turley, Shannon J, Merad, Miriam, Randolph, Gwendalyn J

“…By comparing gene-expression profiles, Randolph and colleagues distinguish different types of macrophages and pinpoint the differences between macrophages and…”
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Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation by Best, J Adam, Blair, David A, Knell, Jamie, Yang, Edward, Mayya, Viveka, Doedens, Andrew, Dustin, Michael L, Goldrath, Ananda W

“…Antigenic activation induces the generation of effector and memory CD8 + T cells. Goldrath and colleagues profile gene expression at various times after…”
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SENTI-101, a Preparation of Mesenchymal Stromal Cells Engineered to Express IL12 and IL21, Induces Localized and Durable Antitumor Immunity in Preclinical Models of Peritoneal Solid Tumors by Gonzalez-Junca, Alba, Liu, Frances D, Nagaraja, Archana S, Mullenix, Alyssa, Lee, Chen-Ting, Gordley, Russell M, Frimannsson, Daniel O, Maller, Ori, Garrison, Brian S, Iyer, Dharini, Benabbas, Anissa, Truong, Tiffany A, Quach, Allison, Tian, Mengxi, Martinez, Rowena, Savur, Rishi, Perry-McNamara, Alyssa, Nguyen, Denny, Almudhfar, Niran, Blanco, Carmina, Huynh, Christina, Nand, Asish, Lay, Yu-An E, Magal, Ashita, Mangalampalli, Sravani, Lee, Philip J, Lu, Timothy K, Lee, Gary

“…Advanced peritoneal carcinomatosis including high-grade ovarian cancer has poor prognoses and a poor response rate to current checkpoint inhibitor…”
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Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells by Cohen, Nadia R, Brennan, Patrick J, Shay, Tal, Watts, Gerald F, Brigl, Manfred, Kang, Joonsoo, Brenner, Michael B

“…Using the Immunological Genome compendium, Brenner and colleagues shed light on the transcriptional programs that operate during the course of i NKT cell…”
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Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways by George, M D, Baba, M, Scott, S V, Mizushima, N, Garrison, B S, Ohsumi, Y, Klionsky, D J

“…The cytoplasm-to-vacuole targeting (Cvt) pathway and macroautophagy are dynamic events involving the rearrangement of membrane to form a sequestering vesicle…”
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Loss of P2Y₁₄ results in an arresting response to hematological stress by Garrison, Brian S, Rossi, Derrick J

“…The regenerative capacity of tissues to recover from injury or stress is dependent on stem cell competence, yet the underlying mechanisms that govern how stem…”
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Intracerebroventricular delivery of hematopoietic progenitors results in rapid and robust engraftment of microglia-like cells by Capotondo, Alessia, Milazzo, Rita, Garcia-Manteiga, Jose M, Cavalca, Eleonora, Montepeloso, Annita, Garrison, Brian S, Peviani, Marco, Rossi, Derrick J, Biffi, Alessandra

“…Recent evidence indicates that hematopoietic stem and progenitor cells (HSPCs) can serve as vehicles for therapeutic molecular delivery to the brain by…”
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Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors by Riddell, Jonah, Gazit, Roi, Garrison, Brian S., Guo, Guoji, Saadatpour, Assieh, Mandal, Pankaj K., Ebina, Wataru, Volchkov, Pavel, Yuan, Guo-Cheng, Orkin, Stuart H., Rossi, Derrick J.

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Controlling stem cell fate one substrate at a time by Rossi, Derrick J, Garrison, Brian S

“…Hematopoietic stem cell self-renewal is tightly regulated. Regulation of the stability of c-Myc protein contributes to this control of hematopoietic stem cell…”
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792. Post-Integrative Gene Silencing in the Sleeping Beauty Transposition System by Garrison, Brian S., Yant, Stephen R., Mikkelsen, Jacob G., Kay, Mark A.

“…The Sleeping Beauty (SB) transposon represents an important vehicle for in vivo gene delivery because it can stably integrate into the genomes of mammalian…”
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Calibrated Release IL15 Bivalent CD33 and/or FLT3 and NOT Emcn Logic Gated Gene Circuit CAR-NK Cell Therapy (SENTI-202) in Venetoclax Resistant Patient Derived Xenograft Acute Myeloid Leukemia Models by Muftuoglu, Muharrem, Basyal, Mahesh, Li, Li, Lv, Jiangxing, Ostermann, Lauren B., Zhao, Ran, Ke, Baozhen, Akiyama, Hiroki, Mak, Po Yee, Carter, Bing Z., Deng, Han, Li, Yongshuai, Garrison, Brian S., Rajangam, Kanya L., Andreeff, Michael

“…Venetoclax (VEN) as combination therapy has improved response rates and overall survival of patients with acute myeloid leukemia (AML). However, once AML…”
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