Search Results - "Garrido, Marlene"

PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer by Chabanon, Roman M, Muirhead, Gareth, Krastev, Dragomir B, Adam, Julien, Morel, Daphné, Garrido, Marlène, Lamb, Andrew, Hénon, Clémence, Dorvault, Nicolas, Rouanne, Mathieu, Marlow, Rebecca, Bajrami, Ilirjana, Cardeñosa, Marta Llorca, Konde, Asha, Besse, Benjamin, Ashworth, Alan, Pettitt, Stephen J, Haider, Syed, Marabelle, Aurélien, Tutt, Andrew Nj, Soria, Jean-Charles, Lord, Christopher J, Postel-Vinay, Sophie

“…The cyclic GMP-AMP synthase/stimulator of IFN genes (cGAS/STING) pathway detects cytosolic DNA to activate innate immune responses. Poly(ADP-ribose) polymerase…”
Get full text

PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer by Chabanon, Roman M, Morel, Daphné, Eychenne, Thomas, Colmet-Daage, Léo, Bajrami, Ilirjana, Dorvault, Nicolas, Garrido, Marlène, Meisenberg, Cornelia, Lamb, Andrew, Ngo, Carine, Hopkins, Suzanna R, Roumeliotis, Theodoros I, Jouny, Samuel, Hénon, Clémence, Kawai-Kawachi, Asuka, Astier, Clémence, Konde, Asha, Del Nery, Elaine, Massard, Christophe, Pettitt, Stephen J, Margueron, Raphaël, Choudhary, Jyoti S, Almouzni, Geneviève, Soria, Jean-Charles, Deutsch, Eric, Downs, Jessica A, Lord, Christopher J, Postel-Vinay, Sophie

“…Inactivation of ( ), a specific subunit of the PBAF chromatin remodeling complex, occurs frequently in cancer, including 40% of clear cell renal cell…”
Get full text

Direct-Acting Antiviral Therapy Restores Immune Tolerance to Patients With Hepatitis C Virus–Induced Cryoglobulinemia Vasculitis by Comarmond, Cloé, Garrido, Marlène, Pol, Stanislas, Desbois, Anne-Claire, Costopoulos, Myrto, Le Garff-Tavernier, Magali, Si Ahmed, Si Nafa, Alric, Laurent, Fontaine, Hélène, Bellier, Bertrand, Maciejewski, Anna, Rosenzwajg, Michelle, Klatzmann, David, Musset, Lucile, Poynard, Thierry, Cacoub, Patrice, Saadoun, David

“…Background & Aims Interferon-free direct-acting antiviral (DAA) therapies are effective in patients with hepatitis C virus–induced cryoglobulinemia vasculitis…”
Get full text

Immunomodulatory role of Interleukin-33 in large vessel vasculitis by Desbois, Anne-Claire, Cacoub, Patrice, Leroyer, Aurélie S., Tellier, Edwige, Garrido, Marlène, Maciejewski-Duval, Anna, Comarmond, Cloé, Barete, Stéphane, Arock, Michel, Bruneval, Patrick, Launay, Jean-Marie, Fouret, Pierre, Blank, Ulrich, Rosenzwajg, Michelle, Klatzmann, David, Jarraya, Mohamed, Cluzel, Philippe, Koskas, Fabien, Kaplanski, Gilles, Saadoun, David

“…The mechanisms regulating inflammation in large vessels vasculitis (LVV) are poorly understood. Interleukin 33 (IL-33) has been shown to license innate and…”
Get full text

Interleukin 21 Correlates with T Cell and B Cell Subset Alterations in Systemic Lupus Erythematosus by TERRIER, Benjamin, COSTEDOAT-CHALUMEAU, Nathalie, GARRIDO, Marlene, GERI, Guillaume, ROSENZWAJG, Michelle, MUSSET, Lucile, KLATZMANN, David, SAADOUN, David, CACOUB, Patrice

“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by alterations of the B cell subset, global regulatory T cell (Treg) depletion, and…”
Get full text

Large-vessel vasculitis in human immunodeficiency virus-infected patients by Ferfar, Yasmina, Savey, Léa, Comarmond, Cloé, Sadaghianloo, Nirvana, Garrido, Marlène, Domont, Fanny, Valantin, Marc Antoine, Pourcher-Martinez, Valérie, Cluzel, Philippe, Fouret, Pierre, Chiche, Laurent, Gaudric, Julien, Koskas, Fabien, Cacoub, Patrice, Saadoun, David

“…The objective of this study was to describe large-vessel vasculitis (LVV) in patients with human immunodeficiency virus (HIV) infection. It is a retrospective…”
Get full text

DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade by Touat, Mehdi, Sourisseau, Tony, Dorvault, Nicolas, Chabanon, Roman M, Garrido, Marlène, Morel, Daphné, Krastev, Dragomir B, Bigot, Ludovic, Adam, Julien, Frankum, Jessica R, Durand, Sylvère, Pontoizeau, Clement, Souquère, Sylvie, Kuo, Mei-Shiue, Sauvaigo, Sylvie, Mardakheh, Faraz, Sarasin, Alain, Olaussen, Ken A, Friboulet, Luc, Bouillaud, Frédéric, Pierron, Gérard, Ashworth, Alan, Lombès, Anne, Lord, Christopher J, Soria, Jean-Charles, Postel-Vinay, Sophie

“…Synthetic lethality is an efficient mechanism-based approach to selectively target DNA repair defects. Excision repair cross-complementation group 1 (ERCC1)…”
Get full text

Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in DSRCTs by Henon, Clémence, Vibert, Julien, Eychenne, Thomas, Gruel, Nadège, Colmet-Daage, Léo, Ngo, Carine, Garrido, Marlène, Dorvault, Nicolas, Marques Da Costa, Maria Eugenia, Marty, Virginie, Signolle, Nicolas, Marchais, Antonin, Herbel, Noé, Kawai-Kawachi, Asuka, Lenormand, Madison, Astier, Clémence, Chabanon, Roman, Verret, Benjamin, Bahleda, Rastislav, Le Cesne, Axel, Mechta-Grigoriou, Fatima, Faron, Matthieu, Honoré, Charles, Delattre, Olivier, Waterfall, Joshua J., Watson, Sarah, Postel-Vinay, Sophie

“…Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive sarcoma driven by the EWSR1::WT1 chimeric transcription factor. Despite this unique oncogenic…”
Get full text

Expansion of functionally anergic CD21-/low marginal zone-like B cell clones in hepatitis C virus infection-related autoimmunity by Terrier, Benjamin, Joly, Florence, Vazquez, Thomas, Benech, Philippe, Rosenzwajg, Michelle, Carpentier, Wassila, Garrido, Marlène, Ghillani-Dalbin, Pascale, Klatzmann, David, Cacoub, Patrice, Saadoun, David

“…Homeostasis of peripheral B cell subsets is disturbed during chronic hepatitis C virus (HCV) infection, leading to the occurrence of autoimmunity and B cell…”
Get full text

Behçet's disease physiopathology: a contemporary review by Zeidan, Mohamad J, Saadoun, David, Garrido, Marlene, Klatzmann, David, Six, Adrien, Cacoub, Patrice

“…Behçet's disease, also known as the Silk Road Disease, is a rare systemic vasculitis disorder of unknown etiology. Recurrent attacks of acute inflammation…”
Get full text

mTOR Pathway Activation in Takayasu Arteriti by Comarmond, Cloe, Leroyer, Aurélie S., Zeidan, Mohamad J., Fourez, Jean-Pierre, Koskas, Fabien, Cluzel, Philippe, Maciejewski-Duval, Anna, Garrido, Marlene, Cacoub, Patrice, Saadoun, David

Get full text

Peripheral blood 8 colour flow cytometry monitoring of hairy cell leukaemia allows detection of high‐risk patients by Garnache Ottou, Francine, Chandesris, Marie‐Olivia, Lhermitte, Ludovic, Callens, Céline, Beldjord, Kheira, Garrido, Marlene, Bedin, Anne‐Sophie, Brouzes, Chantal, Villemant, Sarah, Rubio, Marie‐Thérèse, Belanger, Coralie, Suarez, Felipe, Deau, Bénédicte, Lefrère, François, Hermine, Olivier, Asnafi, Vahid, Varet, Bruno, Macintyre, Elizabeth

“…Summary Although purine analogues have significantly improved the outcome of hairy cell leukaemia (HCL) patients, 30–40% relapse, illustrating the need for…”
Get full text

DNA repair deficiency sensitizes lung cancer cells to [NAD.sup.+] biosynthesis blockade by Touat, Mehdi, Sourisseau, Tony, Dorvault, Nicolas, Chabanon, Roman M, Garrido, Marlene, Morel, Daphne, Krastev, Dragomir B, Bigot, Ludovic, Adam, Julien, Frankum, Jessica R, Durand, Sylvere, Pontoizeau, Clement, Souquere, Sylvie, Kuo, Mei-Shiue, Sauvaigo, Sylvie, Mardakheh, Faraz, Sarasin, Alain, Olaussen, Ken A, Friboulet, Luc, Bouillaud, Frederic, Pierron, Gerard, Ashworth, Alan, Lombes, Anne, Lord, Christopher J, Soria, Jean-Charles, Postel-Vinay, Sophie

“…Synthetic lethality is an efficient mechanism-based approach to selectively target DNA repair defects. Excision repair cross-complementation group 1 (ERCC1)…”
Get full text

Immunomodulatory role of Interleukin-33 in large vessel vasculitis by Desbois, Anne Claire, Cacoub, Patrice, Leroyer, Aurelie S, Tellier, Edwige, Garrido, Marlene, Maciejewski-Duval, Anna, Comarmond, Cloe, Barete, Stéphane, Arock, Michel, Bruneval, Patrick, Launay, Jean Marie, Fouret, Pierre, Blank, Ulrich, Rosenzwajg, Michelle, Klatzmann, David, Jarraya, Mohamed, Cluzel, Philippe, Koskas, Fabien, Kaplanski, Gilles, Saadoun, David

Get full text

Abstract 6277: Identification of ATR inhibitors as therapeutic opportunities in Desmoplastic small round cell tumors by KAWAI-KAWACHI, Asuka, LENORMAND, Madison, HENON, Clémence, EYCHENNE, Thomas, COLMET-DAAGE, Leo, DORVAULT, Nicolas, GARRIDO, Marlene, ASTIER, Clémence, NGO, Carine, PEMBERTON, Helen, GULATI, Aditi, PETTITT, Stephen, CHABANON, Roman, LORD, Christopher J, POSTEL-VINAY, Sophie

“…Abstract Introduction: Desmoplastic small round cell tumor (DSRCT) is a rare and very aggressive subtype of sarcoma, affecting predominantly young males. DSRCT…”
Get full text

Post-Induction Minimal Residual Disease (MRD) Defines a Large Subset of Adults with Favorable Ph-Negative Acute Lymphoblastic Leukemia (ALL), Who Do Not Benefit From Allogeneic Stem Cell Transplantation (SCT) in First Complete Remission: A GRAALL Study by Beldjord, Kheira, Lhéritier, Véronique, Boulland, Marie-Laure, Grardel, Nathalie, Cayuela, Jean-Michel, Cavé, Hélène, Schäfer, Beat, Bakkus, Marleen, Garrido, Marlène, Dhédin, Nathalie, Huynh, Anne, Leguay, Thibaut, Gardin, Claude, Thomas, Xavier, Chalandon, Yves, Huguet, Françoise, Vernant, Jean-Paul, Fest, Thierry, Ifrah, Norbert, Macintyre, Elizabeth, Dombret, Hervé

“…Abstract 577▪▪This icon denotes an abstract that is clinically relevant. Allogeneic SCT is currently the preferred therapeutic option for most younger adults…”
Get full text

Replication Stress is an Actionable Genetic Vulnerability in Desmoplastic Small Round Cell Tumors by Kawai-Kawachi, Asuka, Lenormand, Madison M, Astier, Clémence, Herbel, Noé, Cutrona, Meritxell B, Ngo, Carine, Garrido, Marlène, Eychenne, Thomas, Dorvault, Nicolas, Bordelet, Laetitia, Song, Fei Fei, Bouyakoub, Ryme, Loktev, Anastasia, Romo-Morales, Antonio, Henon, Clémence, Colmet-Daage, Léo, Vibert, Julien, Drac, Marjorie, Brough, Rachel, Schwob, Etienne, Martella, Oliviano, Pinna, Guillaume, Shipley, Janet M, Mittnacht, Sibylle, Zimmermann, Astrid, Gulati, Aditi, Mir, Olivier, Le Cesne, Axel, Faron, Matthieu, Honoré, Charles, Lord, Christopher J, Chabanon, Roman M, Postel-Vinay, Sophie

“…Desmoplastic small round cell tumor (DSRCT) is an aggressive sarcoma subtype that is driven by the EWS-WT1 chimeric transcription factor. The prognosis for…”
Get full text

PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer by Chabanon, Roman, Morel, Daphné, Eychenne, Thomas, Colmet-Daage, Léo, Bajrami, Ilirjana, Dorvault, Nicolas, Garrido, Marlène, Meisenberg, Cornelia, Lamb, Andrew, Ngo, Carine, Hopkins, Suzanna, Roumeliotis, Theodoros, Jouny, Samuel, Hénon, Clémence, Kawai-Kawachi, Asuka, Astier, Clémence, Konde, Asha, del Nery, Elaine, Massard, Christophe, Pettitt, Stephen, Margueron, Raphaël, Choudhary, Jyoti, Almouzni, Geneviève, Soria, Jean-Charles, Deutsch, Eric, Downs, Jessica, Lord, Christopher, Postel-Vinay, Sophie

“…Abstract Inactivation of Polybromo 1 (PBRM1), a specific subunit of the PBAF chromatin remodeling complex, occurs frequently in cancer, including 40% of clear…”
Get full text

Abstract 1058: Targeting chromatin remodeling-associated genetic vulnerabilities in cancer: PBRM1 defects are synthetic lethal with PARP and ATR inhibitors by Chabanon, Roman Merial, Morel, Daphné, Colmet-Daage, Léo, Eychenne, Thomas, Dorvault, Nicolas, Bajrami, Ilirjana, Garrido, Marlène, Hopkins, Suzanna, Meisenberg, Cornelia, Lamb, Andrew, Roumeliotis, Theo, Jouny, Samuel, Astier, Clémence, Konde, Asha, Almouzni, Geneviève, Choudhary, Jyoti, Soria, Jean-Charles, Downs, Jessica, Lord, Christopher J., Postel-Vinay, Sophie

“…Abstract Aim: Polybromo-1 (PBRM1), a specific subunit of the pBAF chromatin remodeling complex, is frequently inactivated in cancer. For example, 40% of clear…”
Get full text

Immunomodulatory role of Interleukin-33 in large vessel vasculitis by Desbois, Anne-Claire, Cacoub, Patrice, Leroyer, Aurelie, Tellier, Edwige, Garrido, Marlène, Maciejewski-Duval, Anna, Comarmond, Cloé, Barete, Stéphane, Arock, Michel, Bruneval, Patrick, Launay, Jean-Marie, Fouret, Pierre, Blank, Ulrich, Rosenzwajg, Michelle, Klatzmann, David, Jarraya, Mohamed, Cluzel, Philippe, Koskas, Fabien, Kaplanski, Gilles, Saadoun, David

“…The mechanisms regulating inflammation in large vessels vasculitis (LVV) are poorly understood. Interleukin 33 (IL-33) has been shown to license innate and…”
Get full text