Search Results - "Garrick, Laura M"

A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese by Wolff , Natascha A., Garrick, Michael D., Zhao, Lin, Garrick, Laura M., Ghio, Andrew J., Thévenod, Frank

“…Much of iron and manganese metabolism occurs in mitochondria. Uptake of redox-active iron must be tightly controlled, but little is known about how metal ions…”
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Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease by Salazar, Julio, Mena, Natalia, Hunot, Stephane, Prigent, Annick, Alvarez-Fischer, Daniel, Arredondo, Miguel, Duyckaerts, Charles, Sazdovitch, Veronique, Zhao, Lin, Garrick, Laura M, Nuñez, Marco T, Garrick, Michael D, Raisman-Vozari, Rita, Hirsch, Etienne C

“…Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson's disease (PD), but the neurodegenerative mechanisms have not been completely…”
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Divalent metal transporter 1 (Dmt1) mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells by Jiang, Lingli, Garrick, Michael D, Garrick, Laura M, Zhao, Lin, Collins, James F

“…Intracellular copper-binding proteins (metallothionein I/II) and a copper exporter (Menkes copper-transporting ATPase) are upregulated in duodenal enterocytes…”
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Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation by Garrick, Michael D., Zhao, Lin, Roth, Jerome A., Jiang, Houbo, Feng, Jian, Foot, Natalie J., Dalton, Hazel, Kumar, Sharad, Garrick, Laura M.

“…Divalent metal ion transporter (DMT1) is the major transporter for iron entrance into mammalian cells and iron exit from endosomes during the transferrin…”
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Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion by Garrick, Michael D, Kuo, Hung-Chieh, Vargas, Farida, Singleton, Steven, Zhao, Lin, Smith, Jaime J, Paradkar, Prasad, Roth, Jerome A, Garrick, Laura M

“…DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes…”
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DMT1: which metals does it transport? by Garrick, Michael D, Singleton, Steven T, Vargas, Farida, Kuo, H-C, Zhao, Lin, Knöpfel, Martin, Davidson, Todd, Costa, Max, Paradkar, Prasad, Roth, Jerome A, Garrick, Laura M

“…DMT1-Divalent Metal (Ion) Transporter 1 or SLC11A2/DCT1/Nramp2 - transports Fe2+ into the duodenum and out of the endosome during the transferrin cycle. DMTI…”
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Nramp2 is Mutated in the Anemic Belgrade (b) Rat: Evidence of a Role for Nramp2 in Endosomal Iron Transport by Fleming, Mark D., Romano, Michelle A., Su, Maureen A., Garrick, Laura M., Garrick, Michael D., Andrews, Nancy C.

“…The Belgrade (b) rat has an autosomal recessively inherited, microcytic, hypochromic anemia associated with abnormal reticulocyte iron uptake and…”
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Lung injury after ozone exposure is iron dependent by Ghio, Andrew J, Turi, Jennifer L, Madden, Michael C, Dailey, Lisa A, Richards, Judy D, Stonehuerner, Jacqueline G, Morgan, Daniel L, Singleton, Steven, Garrick, Laura M, Garrick, Michael D

“…We tested the hypothesis that oxidative stress and biological effect after ozone (O3) exposure are dependent on changes in iron homeostasis. After O3 exposure,…”
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Fetal factors disrupt placental and maternal iron homeostasis in murine β-thalassemia by Yu, Yang, Woloshun, Regina R., Lee, Jennifer K., Ebea, Pearl Onuwa, Zhu, Sean, Nemeth, Elizabeta, Garrick, Laura M., Garrick, Michael D., Collins, James F.

“…•Hyperferremia in thalassemic dams caused iron loading of Th3/+ and WT fetuses, potentiating intrauterine (fetal) growth restriction.•Hepatic Hamp was…”
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Cellular iron transport by Garrick, Michael D., Garrick, Laura M.

“…Iron has a split personality as an essential nutrient that also has the potential to generate reactive oxygen species. We discuss how different cell types…”
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Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1) by Wolff, Natascha A., Ghio, Andrew J., Garrick, Laura M., Garrick, Michael D., Zhao, Lin, Fenton, Robert A, Thévenod, Frank

“…ABSTRACT In mammalian cells, mitochondria receive most incoming iron, yet no entry pathway for iron at the outer mitochondrial membrane (OMM) has been…”
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A direct comparison of divalent metal-ion transporter (DMT1) and hinokitiol, a potential small molecule replacement by Garrick, Michael D., Garrick, Laura M., Zhao, Lin, Collins, James F., Soukup, Joleen, Ghio, Andrew J.

“…Hinokitiol, a natural lipophilic chelator, appears capable of replacing several iron transporters after they have been genetically ablated. Divalent metal-ion…”
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Iron homeostasis in the lung by Ghio, Andrew J, Turi, Jennifer L, Yang, Funmei, Garrick, Laura M, Garrick, Michael D

“…Iron is essential for many aspects of cellular function. However, it also can generate oxygen-based free radicals that result in injury to biological…”
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Iron handling and gene expression of the divalent metal transporter, DMT1, in the kidney of the anemic Belgrade (b) rat by Ferguson, Carole J., Wareing, Mark, Delannoy, Mathieu, Fenton, Robert, Mclarnon, Stuart J., Ashton, Nicholas, Cox, Alan G., Mcmahon, Raymond F.T., Garrick, Laura M., Green, Roger, Smith, Craig P., Riccardi, Daniela

“…Iron handling and gene expression of the divalent metal transporter, DMT1, in the kidney of the anemic Belgrade (b) rat. We have previously shown that the rat…”
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Mitochondria represent another locale for the divalent metal transporter 1 (DMT1) by Wolff, Natascha A, Garrick, Laura M, Zhao, Lin, Garrick, Michael D, Thévenod, Frank

“…The divalent metal transporter (DMT1) is well known for its roles in duodenal iron absorption across the apical enterocyte membrane, in iron efflux from the…”
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Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators by Collins, James F, Hu, Zihua, Ranganathan, P N, Feng, Dian, Garrick, Laura M, Garrick, Michael D, Browne, Richard W

“…To identify novel genes associated with iron metabolism, we performed gene chip studies in two models of iron deficiency: iron-deprived rats and rats deficient…”
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Calcium-channel blockers do not affect iron transport mediated by divalent metal-ion transporter-1 by Mackenzie, Bryan, Shawki, Ali, Ghio, Andrew J., Stonehuerner, Jacqueline D., Zhao, Lin, Ghadersohi, Saied, Garrick, Laura M., Garrick, Michael D.

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Divalent metal transporter-1 decreases metal-related injury in the lung by Ghio, Andrew J, Piantadosi, Claude A, Wang, Xinchao, Dailey, Lisa A, Stonehuerner, Jacqueline D, Madden, Michael C, Yang, Funmei, Dolan, Kevin G, Garrick, Michael D, Garrick, Laura M

“…Exposure to airborne particulates makes the detoxification of metals a continuous challenge for the lungs. Based on the fate of iron in airway epithelial…”
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Dysregulation of Iron Homeostasis in Beta‐thalassemia Intermedia ( Th3/+ ) Mice During Pregnancy by Yu, Yang, Woloshun, Regina R., Lee, Jennifer K., Ebea, Pearl Onuwa, Zhu, Sean, Garrick, Laura M., Garrick, Michael D., Collins, James F.

“…Abstract only Beta‐thalassemia is a disease associated with decreased β‐globin production due to mutations in the β‐globin gene and characterized by chronic…”
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Loss of rapid transferrin receptor recycling due to a mutation in Sec15l1 in hbd mice by Garrick, Michael D., Garrick, Laura M.

“…The hbd ( hemoglobin deficit) mutation affects iron trafficking in murine reticulocytes. It is due to a deletion that eliminates exon 8 of Sec15l1, the homolog…”
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