Search Results - "Garrett, Roger"

Selective and hyperactive uptake of foreign DNA by adaptive immune systems of an archaeon via two distinct mechanisms by Erdmann, Susanne, Garrett, Roger A.

“…Summary Central to the disparate adaptive immune systems of archaea and bacteria are clustered regularly interspaced short palindromic repeats (CRISPR). The…”
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CRISPR-Cas systems are widespread accessory elements across bacterial and archaeal plasmids by Pinilla-Redondo, Rafael, Russel, Jakob, Mayo-Muñoz, David, Shah, Shiraz A, Garrett, Roger A, Nesme, Joseph, Madsen, Jonas S, Fineran, Peter C, Sørensen, Søren J

“…Many prokaryotes encode CRISPR-Cas systems as immune protection against mobile genetic elements (MGEs), yet a number of MGEs also harbor CRISPR-Cas components…”
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Type IV CRISPR-Cas systems are highly diverse and involved in competition between plasmids by Pinilla-Redondo, Rafael, Mayo-Muñoz, David, Russel, Jakob, Garrett, Roger A, Randau, Lennart, Sørensen, Søren J, Shah, Shiraz A

“…CRISPR-Cas systems provide prokaryotes with adaptive immune functions against viruses and other genetic parasites. In contrast to all other types of CRISPR-Cas…”
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Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants by Makarova, Kira S., Wolf, Yuri I., Iranzo, Jaime, Shmakov, Sergey A., Alkhnbashi, Omer S., Brouns, Stan J. J., Charpentier, Emmanuelle, Cheng, David, Haft, Daniel H., Horvath, Philippe, Moineau, Sylvain, Mojica, Francisco J. M., Scott, David, Shah, Shiraz A., Siksnys, Virginijus, Terns, Michael P., Venclovas, Česlovas, White, Malcolm F., Yakunin, Alexander F., Yan, Winston, Zhang, Feng, Garrett, Roger A., Backofen, Rolf, van der Oost, John, Barrangou, Rodolphe, Koonin, Eugene V.

“…The number and diversity of known CRISPR–Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of…”
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A novel interference mechanism by a type IIIB CRISPR‐Cmr module in Sulfolobus by Deng, Ling, Garrett, Roger A., Shah, Shiraz A., Peng, Xu, She, Qunxin

“…Summary Recent studies on CRISPR‐based adaptive immune systems have revealed extensive structural and functional diversity of the interference complexes which…”
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An updated evolutionary classification of CRISPR–Cas systems by Makarova, Kira S., Wolf, Yuri I., Alkhnbashi, Omer S., Costa, Fabrizio, Shah, Shiraz A., Saunders, Sita J., Barrangou, Rodolphe, Brouns, Stan J. J., Charpentier, Emmanuelle, Haft, Daniel H., Horvath, Philippe, Moineau, Sylvain, Mojica, Francisco J. M., Terns, Rebecca M., Terns, Michael P., White, Malcolm F., Yakunin, Alexander F., Garrett, Roger A., van der Oost, John, Backofen, Rolf, Koonin, Eugene V.

“…Key Points CRISPR–Cas systems provide archaea and bacteria with adaptive immunity against viruses and plasmids. CRISPR–Cas genomic loci show extreme diversity…”
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Protospacer recognition motifs: Mixed identities and functional diversity by Shah, Shiraz A., Erdmann, Susanne, Mojica, Francisco J.M., Garrett, Roger A.

“…Protospacer adjacent motifs (PAMs) were originally characterized for CRISPR-Cas systems that were classified on the basis of their CRISPR repeat sequences. A…”
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CRISPR adaptive immune systems of Archaea by Vestergaard, Gisle, Garrett, Roger A, Shah, Shiraz A

“…CRISPR adaptive immune systems were analyzed for all available completed genomes of archaea, which included representatives of each of the main archaeal phyla…”
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Diverse CRISPR-Cas responses and dramatic cellular DNA changes and cell death in pKEF9-conjugated Sulfolobus species by Liu, Guannan, She, Qunxin, Garrett, Roger A

“…The Sulfolobales host a unique family of crenarchaeal conjugative plasmids some of which undergo complex rearrangements intracellularly. Here we examined the…”
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Viruses of the Archaea: a unifying view by Prangishvili, David, Forterre, Patrick, Garrett, Roger A

“…DNA viruses of the Archaea have highly diverse and often exceptionally complex morphotypes. Many have been isolated from geothermally heated hot environments,…”
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Characterizing leader sequences of CRISPR loci by Alkhnbashi, Omer S, Shah, Shiraz A, Garrett, Roger A, Saunders, Sita J, Costa, Fabrizio, Backofen, Rolf

“…The CRISPR-Cas system is an adaptive immune system in many archaea and bacteria, which provides resistance against invading genetic elements. The first phase…”
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Inter‐viral conflicts that exploit host CRISPR immune systems of Sulfolobus by Erdmann, Susanne, Le Moine Bauer, Sven, Garrett, Roger A.

“…Summary Infection of Sulfolobus islandicus REY15A with mixtures of different Sulfolobus viruses, including STSV2, did not induce spacer acquisition by the host…”
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Archaeal CRISPR-based immune systems: exchangeable functional modules by Garrett, Roger A, Vestergaard, Gisle, Shah, Shiraz A

“…CRISPR (clustered regularly interspaced short palindromic repeats)-based immune systems are essentially modular with three primary functions: the excision and…”
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Comprehensive search for accessory proteins encoded with archaeal and bacterial type III CRISPR-cas gene cassettes reveals 39 new cas gene families by Shah, Shiraz A., Alkhnbashi, Omer S., Behler, Juliane, Han, Wenyuan, She, Qunxin, Hess, Wolfgang R., Garrett, Roger A., Backofen, Rolf

“…A study was undertaken to identify conserved proteins that are encoded adjacent to cas gene cassettes of Type III CRISPR-Cas (Clustered Regularly Interspaced…”
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Dynamic properties of the Sulfolobus CRISPR/Cas and CRISPR/Cmr systems when challenged with vector‐borne viral and plasmid genes and protospacers by Gudbergsdottir, Soley, Deng, Ling, Chen, Zhengjun, Jensen, Jaide V. K., Jensen, Linda R., She, Qunxin, Garrett, Roger A.

“…Summary The adaptive immune CRISPR/Cas and CRISPR/Cmr systems of the crenarchaeal thermoacidophile Sulfolobus were challenged by a variety of viral and plasmid…”
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CRISPR families of the crenarchaeal genus Sulfolobus: bidirectional transcription and dynamic properties by Lillestøl, Reidun K, Shah, Shiraz A, Brügger, Kim, Redder, Peter, Phan, Hien, Christiansen, Jan, Garrett, Roger A

“…Clusters of regularly interspaced short palindromic repeats (CRISPRs) of Sulfolobus fall into three main families based on their repeats, leader regions,…”
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Transcriptome changes in STSV2-infected Sulfolobus islandicusREY15A undergoing continuous CRISPR spacer acquisition by Leon-Sobrino, Carlos, Kot, Witold P, Garrett, Roger A

“…Summary A transcriptome study was performed on Sulfolobus islandicusREY15A actively undergoing CRISPR spacer acquisition from the crenarchaeal monocaudavirus…”
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Reflections on delirium – A patient’s perspective by Garrett, Roger M

“…Delirium, and its importance, is briefly discussed to contextualise the intricate story of one patient’s experience of the condition. This recounting of the…”
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CRISPRstrand: predicting repeat orientations to determine the crRNA-encoding strand at CRISPR loci by Alkhnbashi, Omer S, Costa, Fabrizio, Shah, Shiraz A, Garrett, Roger A, Saunders, Sita J, Backofen, Rolf

“…The discovery of CRISPR-Cas systems almost 20 years ago rapidly changed our perception of the bacterial and archaeal immune systems. CRISPR loci consist of…”
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Genome Analyses of Icelandic Strains of Sulfolobus islandicus, Model Organisms for Genetic and Virus-Host Interaction Studies by Guo, Li, Brügger, Kim, Liu, Chao, Shah, Shiraz A, Zheng, Huajun, Zhu, Yongqiang, Wang, Shengyue, Lillestøl, Reidun K, Chen, Lanming, Frank, Jeremy, Prangishvili, David, Paulin, Lars, She, Qunxin, Huang, Li, Garrett, Roger A

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