Search Results - "Garrett, P. J."

Structure and function of the type 1 insulin-like growth factor receptor by Adams, T. E, Epa, V. C, Garrett, T. P. J, Ward, C. W

“…The type 1 insulin-like growth factor receptor (IGF-1R), a transmembrane tyrosine kinase, is widely expressed across many cell types in foetal and postnatal…”
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unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor by Huyton, Trevor, Zhang, Jian-Guo, Luo, Cindy S, Lou, Mei-Zhen, Hilton, Douglas J, Nicola, Nicos A, Garrett, Thomas P.J

“…Leukemia inhibitory factor (LIF) receptor is a cell surface receptor that mediates the actions of LIF and other IL-6 type cytokines through the formation of…”
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Antibodies specifically targeting a locally misfolded region of tumor associated EGFR by Garrett, Thomas P.J, Burgess, Antony W, Gan, Hui K, Luwor, Rod B, Cartwright, Glenn, Walker, Francesca, Orchard, Suzanne G, Clayton, Andrew H.A, Nice, Edouard C, Rothacker, Julie, Catimel, Bruno, Cavenee, Webster K, Old, Lloyd J, Stockert, Elisabeth, Ritter, Gerd, Adams, Timothy E, Hoyne, Peter A, Wittrup, Dane, Chao, Ginger, Cochran, Jennifer R, Luo, Cindy, Lou, Mezhen, Huyton, Trevor, Xu, Yibin, Fairlie, W. Douglas, Yao, Shenggen, Scott, Andrew M, Johns, Terrance G

“…Epidermal Growth Factor Receptor (EGFR) is involved in stimulating the growth of many human tumors, but the success of therapeutic agents has been limited in…”
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Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor by Garrett, Thomas P. J, Bentley, John D, Ward, Colin W, McKern, Neil M, Lou, Meizhen, Frenkel, Maurice J, Lovrecz, George O, Elleman, Thomas C, Cosgrove, Leah J

“…The type-1 insulin-like growth-factor receptor (IGF-1R) and insulin receptor (IR) are closely related members of the tyrosine-kinase receptor superfamily. IR…”
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The First Three Domains of the Insulin Receptor Differ Structurally from the Insulin-like Growth Factor 1 Receptor in the Regions Governing Ligand Specificity by Lou, Meizhen, Garrett, Thomas P. J., McKern, Neil M., Hoyne, Peter A., Epa, V. Chandana, Bentley, John D., Lovrecz, George O., Cosgrove, Leah J., Frenkel, Maurice J., Ward, Colin W.

“…The insulin receptor (IR) and the type-1 insulin-like growth factor receptor (IGF1R) are homologous multidomain proteins that bind insulin and IGF with…”
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Integrated organismal responses induced by projected levels of CO 2 and temperature exposures in the early life stages of lake sturgeon by Belding, Luke D, Thorstensen, Matt J, Quijada-Rodriguez, Alex R, Bugg, William S, Yoon, Gwangseok R, Loeppky, Alison R, Allen, Garrett J P, Schoen, Alexandra N, Earhart, Madison L, Brandt, Catherine, Ali, Jennifer L, Weihrauch, Dirk, Jeffries, Kenneth M, Anderson, W Gary

“…Atmospheric CO and temperature are rising concurrently, and may have profound impacts on the transcriptional, physiological and behavioural responses of…”
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Structure of a calcium-deficient form of influenza virus neuraminidase: implications for substrate binding by Smith, Brian J., Huyton, Trevor, Joosten, Robbie P., McKimm-Breschkin, Jennifer L., Zhang, Jian-Guo, Luo, Cindy S., Lou, Mei-Zhen, Labrou, Nikolaos E., Garrett, Thomas P. J.

“…The X‐ray structure of influenza virus neuraminidase (NA) isolated from whale, subtype N9, has been determined at 2.2 Å resolution and contains a tetrameric…”
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Integrated organismal responses induced by projected levels of CO2 and temperature exposures in the early life stages of lake sturgeon by Belding, Luke D., Thorstensen, Matt J., Quijada‐Rodriguez, Alex R., Bugg, William S., Yoon, Gwangseok R., Loeppky, Alison R., Allen, Garrett J. P., Schoen, Alexandra N., Earhart, Madison L., Brandt, Catherine, Ali, Jennifer L., Weihrauch, Dirk, Jeffries, Kenneth M., Anderson, W. Gary

“…Atmospheric CO2 and temperature are rising concurrently, and may have profound impacts on the transcriptional, physiological and behavioural responses of…”
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Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains by Wang, Jiahuai, Yan, Youwei, Garrett, Thomas P. J, Liu, Jinhuan, Rodgers, David W, Garlick, Robert L, Tarr, George E, Husain, Yasmin, Reinherz, Ellis L, Harrison, Stephen C

“…The structure of an N-terminal fragment of CD4 has been determined to 2.4 A resolution. It has two tightly abutting domains connected by a continuous beta…”
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Specificity pockets for the side chains of peptide antigens in HLA-Aw68 by Garrett, T. P. J, Saper, M. A, Bjorkman, P. J, Strominger, J. L, Wiley, D. C

“…We have determined the structure of a second human histocompatibility glycoprotein, HLA-Aw68, by X-ray crystallography and refined it to a resolution of 2.6 A…”
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Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1 by Redpath, Nicholas T, Xu, Yibin, Wilson, Nicholas J, Fabri, Louis J, Baca, Manuel, Andrews, Arna E, Braley, Hal, Lu, Ping, Ireland, Cheryl, Ernst, Robin E, Woods, Andrea, Forrest, Gail, An, Zhiqiang, Zaller, Dennis M, Strohl, William R, Luo, Cindy S, Czabotar, Peter E, Garrett, Thomas P J, Hilton, Douglas J, Nash, Andrew D, Zhang, Jian-Guo, Nicola, Nicos A

“…Gene deletion studies in mice have revealed critical roles for IL (interleukin)-4 and -13 in asthma development, with the latter controlling lung airways…”
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Re-editing Towneley by Epp, Garrett P. J

“…In 1936, when the Surtees Society published the first modern edition of the contents ofHuntington MS HM 1— still at that point owned by the Towneley family in…”
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Body fat and time of year interact to mediate dispersal behaviour in ground squirrels by NUNES, SCOTT, HA, CO-DIEM T, GARRETT, PAULA J, MUEKE, EVA-MARIA, SMALE, LAURA, HOLEKAMP, KAY E

“…Behaviour is often influenced by energy availability. Hibernation presents an energetic challenge to Belding's ground squirrels,Spermophilus beldingi, which…”
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Crystal Structure of the Entire Ectodomain of gp130: INSIGHTS INTO THE MOLECULAR ASSEMBLY OF THE TALL CYTOKINE RECEPTOR COMPLEXES by Xu, Yibin, Kershaw, Nadia J, Luo, Cindy S, Soo, Priscilla, Pocock, Michael J, Czabotar, Peter E, Hilton, Douglas J, Nicola, Nicos A, Garrett, Thomas P.J, Zhang, Jian-Guo

“…gp130 is the shared signal-transducing receptor subunit for the large and important family of interleukin 6-like cytokines. Previous x-ray structures of…”
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Sarcoidosis and primary systemic vasculitis by WATSON, I, HILL, C. M, BIGGART, J. D, RUSSELL, C. J, GARRETT, P. J

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Weight at birth and other factors influencing progression of idiopathic membranous nephropathy by Duncan, R C, Bass, P S, Garrett, P J, Dathan, J R

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CR1/CR2 Interactions Modulate the Functions of the Cell Surface Epidermal Growth Factor Receptor by Walker, Francesca, Orchard, Suzanne G, Jorissen, Robert N, Hall, Nathan E, Zhang, Hui-Hua, Hoyne, Peter A, Adams, Timothy E, Johns, Terrance G, Ward, Colin, Garrett, Thomas P J, Zhu, Hong-Jian, Nerrie, Maureen, Scott, Andrew M, Nice, Edouard C, Burgess, Antony W

“…Recent crystallographic data on the isolated extracellular domain of the epidermal growth factor receptor (EGFR) have suggested a model for its activation by…”
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The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules by Ward, C W, Garrett, T P

“…Leucine-rich repeats are one of the more common modules found in proteins. The leucine-rich repeat consensus motif is LxxLxLxxNxLxxLxxLxxLxx- where the first…”
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SPRY Domain-Containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding by Kuang, Zhihe, Yao, Shenggen, Xu, Yibin, Lewis, Rowena S., Low, Andrew, Masters, Seth L., Willson, Tracy A., Kolesnik, Tatiana B., Nicholson, Sandra E., Garrett, Thomas J.P., Norton, Raymond S.

“…The four mammalian SPRY (a sequence repeat in dual-specificity kinase splA and ryanodine receptors) domain-containing suppressor of cytokine signalling (SOCS)…”
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AIDS presenting as focal segmental membranous glomerulopathy by Bass, P S, Garrett, P J, Ellison, D W, Terry, P, O'Connell, S, Theaker, J M, Dathan, J R, Fine, D

“…The case of a young, heterosexual man who was investigated for proteinuria is reported. A renal biopsy specimen showed a focal and segmental membranous…”
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