Search Results - "Garrad, Richard C"

Src Homology 3 Binding Sites in the P2Y2 Nucleotide Receptor Interact with Src and Regulate Activities of Src, Proline-rich Tyrosine Kinase 2, and Growth Factor Receptors by Liu, Jun, Liao, Zhongji, Camden, Jean, Griffin, Korey D., Garrad, Richard C., Santiago-Pérez, Laura I., González, Fernando A., Seye, Cheikh I., Weisman, Gary A., Erb, Laurie

“…Many G protein-coupled receptors activate growth factor receptors, although the mechanisms controlling this transactivation are unclear. We have identified two…”
Get full text

Agonist-induced phosphorylation and desensitization of the P2Y2 nucleotide receptor by Flores, Rosa V, Hernández-Pérez, Melvin G, Aquino, Edna, Garrad, Richard C, Weisman, Gary A, Gonzalez, Fernando A

“…Purification of HA-tagged P2Y2 receptors from transfected human 1321N1 astrocytoma cells yielded a protein with a molecular size determined by SDS-PAGE to be…”
Get full text

Functional P2Y2 nucleotide receptors mediate uridine 5'-triphosphate-induced intimal hyperplasia in collared rabbit carotid arteries by SEYE, Cheikh I, QIONGMAN KONG, ERB, Laurie, GARRAD, Richard C, KRUGH, Brent, MEIFANG WANG, TURNER, John T, STUREK, Michael, GONZALEZ, Fernando A, WEISMAN, Gary A

“…Extracellular uridine 5'-triphosphate (UTP) induces mitogenic activation of smooth muscle cells (SMCs) through binding to P2Y2 nucleotide receptors. P2Y2…”
Get full text

Cloning, Expression, and Chromosomal Localization of the Human Uridine Nucleotide Receptor Gene (∗) by Nguyen, Tuan, Erb, Laurie, Weisman, Gary A., Marchese, Adriano, Heng, Henry H.Q., Garrad, Richard C., George, Susan R., Turner, John T., O'Dowd, Brian F.

“…Extracellular ATP and ADP mediate diverse physiological responses in mammalian cells, in part through the activation of G protein-coupled P2 purinoceptors. The…”
Get full text

Functional analysis through site-directed mutations and phylogeny of the Candida albicans LYS1-encoded saccharopine dehydrogenase by Guo, Shujuan, Garrad, Richard C, Bhattacharjee, J. K

“…Candida albicans LYS1-encoded saccharopine dehydrogenase (CaLys1p, SDH) catalyzes the final biosynthetic step (saccharopine to lysine + α-ketoglutarate) of the…”
Get full text

Mechanisms of agonist-dependent and -independent desensitization of a recombinant P2Y2 nucleotide receptor by Otero, M, Garrad, R C, Velázquez, B, Hernández-Pérez, M G, Camden, J M, Erb, L, Clarke, L L, Turner, J T, Weisman, G A, González, F A

“…UTP activates P2Y, receptors in both 1321N1 cell transfectants expressing the P2Y2 receptor and human HT-29 epithelial cells expressing endogenous P2Y,…”
Get full text

Differential agonist-induced desensitization of P2Y2 nucleotide receptors by ATP and UTP by Velázquez, B, Garrad, R C, Weisman, G A, González, F A

“…The equal potency and efficacy of the agonists, ATP and UTP, pharmacologically distinguish the P2Y2 receptor from other nucleotide receptors. Investigation of…”
Get full text

Desensitization of P2Y2 receptor-activated transepithelial anion secretion by Clarke, L L, Harline, M C, Otero, M A, Glover, G G, Garrad, R C, Krugh, B, Walker, N M, González, F A, Turner, J T, Weisman, G A

“…Desensitization of P2Y2 receptor-activated anion secretion may limit the usefulness of extracellular nucleotides in secretagogue therapy of epithelial…”
Get full text

Structural Basis of Agonist-induced Desensitization and Sequestration of the P2Y2 Nucleotide Receptor by Garrad, Richard C., Otero, Miguel A., Erb, Laurie, Theiss, Patty M., Clarke, Lane L., Gonzalez, Fernando A., Turner, John T., Weisman, Gary A.

“…Molecular determinants of P2Y2receptor desensitization and sequestration have been investigated. Wild-type P2Y2 receptors and a series of five C-terminal…”
Get full text

Functional P2Y(2) nucleotide receptors mediate uridine 5'-triphosphate-induced intimal hyperplasia in collared rabbit carotid arteries by Seye, Cheikh I, Kong, Qiongman, Erb, Laurie, Garrad, Richard C

“…BACKGROUND: Extracellular uridine 5'-triphosphate (UTP) induces mitogenic activation of smooth muscle cells (SMCs) through binding to P2Y2 nucleotide…”
Get full text

P2Y2 nucleotide receptor signaling in human monocytic cells: Activation, desensitization and coupling to mitogen-activated protein kinases by Santiago-Pérez, Laura I., Flores, Rosa V., Santos-Berríos, Cynthia, Chorna, Nataliya E., Krugh, Brent, Garrad, Richard C., Erb, Laurie, Weisman, Gary A., González, Fernando A.

“…Activation of P2Y2 receptors by extracellular nucleotides has been shown to induce phenotypic differentiation of human promonocytic U937 cells that is…”
Get full text

Structural basis of agonist-induced desensitization and sequestration of the P2Y2 nucleotide receptor. Consequences of truncation of the C terminus by Garrad, R C, Otero, M A, Erb, L, Theiss, P M, Clarke, L L, Gonzalez, F A, Turner, J T, Weisman, G A

“…Molecular determinants of P2Y2 receptor desensitization and sequestration have been investigated. Wild-type P2Y2 receptors and a series of five C-terminal…”
Get full text

Agonist-induced phosphorylation and desensitization of the P2Y sub(2) nucleotide receptor by Flores, Rosa V, Hernandez-Perez, Melvin G, Aquino, Edna, Garrad, Richard C, Weisman, Gary A, Gonzalez, Fernando A

“…Purification of HA-tagged P2Y sub(2) receptors from transfected human 1321N1 astrocytoma cells yielded a protein with a molecular size determined by SDS-PAGE…”
Get full text

Functional P2Y 2 Nucleotide Receptors Mediate Uridine 5′-Triphosphate–Induced Intimal Hyperplasia in Collared Rabbit Carotid Arteries by Seye, Cheikh I., Kong, Qiongman, Erb, Laurie, Garrad, Richard C., Krugh, Brent, Wang, Meifang, Turner, John T., Sturek, Michael, González, Fernando A., Weisman, Gary A.

“…Background— Extracellular uridine 5′-triphosphate (UTP) induces mitogenic activation of smooth muscle cells (SMCs) through binding to P2Y 2 nucleotide…”
Get full text

P2Y 2 nucleotide receptor signaling in human monocytic cells: Activation, desensitization and coupling to mitogen‐activated protein kinases by Santiago‐Pérez, Laura I., Flores, Rosa V., Santos‐Berríos, Cynthia, Chorna, Nataliya E., Krugh, Brent, Garrad, Richard C., Erb, Laurie, Weisman, Gary A., González, Fernando A.

“…Activation of P2Y 2 receptors by extracellular nucleotides has been shown to induce phenotypic differentiation of human promonocytic U937 cells that is…”
Get full text

Changes in P2Y1 nucleotide receptor activity during the development of rat salivary glands by Park, M K, Garrad, R C, Weisman, G A, Turner, J T

“…Experiments that used dispersed salivary gland cells from 1-day-old rats indicated the presence of the P2Y nucleotide receptor subtype, P2Y1, based on the…”
Get full text

An RGD Sequence in the P2Y2 Receptor Interacts with α Vβ 3 Integrins and Is Required for Go-Mediated Signal Transduction by Erb, Laurie, Liu, Jun, Ockerhausen, Jonathan, Kong, Qiongman, Garrad, Richard C., Griffin, Korey, Neal, Chris, Krugh, Brent, Santiago-Pérez, Laura I., González, Fernando A., Gresham, Hattie D., Turner, John T., Weisman, Gary A.

“…The P2Y2 nucleotide receptor (P2Y2R) contains the integrin-binding domain arginine-glycine-aspartic acid (RGD) in its first extracellular loop, raising the…”
Get full text

An Rgd Sequence in the P2y2 Receptor Interacts with αVβ3 Integrins and Is Required for Go-Mediated Signal Transduction by Erb, Laurie, Liu, Jun, Ockerhausen, Jonathan, Kong, Qiongman, Garrad, Richard C., Griffin, Korey, Neal, Chris, Krugh, Brent, Santiago-Pérez, Laura I., González, Fernando A., Gresham, Hattie D., Turner, John T., Weisman, Gary A.

“…The P2Y2 nucleotide receptor (P2Y2R) contains the integrin-binding domain arginine-glycine-aspartic acid (RGD) in its first extracellular loop, raising the…”
Get full text

Mechanisms of agonist-dependent and -independent desensitization of a recombinant P2Y sub(2) nucleotide receptor by Otero, Miguel, Garrad, Richard C, Velazquez, Betty, Hernandez-Perez, Melvin G, Camden, Jean M, Erb, Laurie, Clarke, Lane L, Turner, John T, Weisman, Gary A, Gonzalez, Fernando A

“…UTP activates P2Y sub(2) receptors in both 1321N1 cell transfectants expressing the P2Y sub(2) receptor and human HT-29 epithelial cells expressing endogenous…”
Get full text

Lysine biosynthesis in selected pathogenic fungi: characterization of lysine auxotrophs and the cloned LYS1 gene of Candida albicans by GARRAD, R. C, BHATTACHARJEE, J. K

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text