Search Results - "Garovoy, M."

A Phase I/II Randomized Open‐Label Multicenter Trial of Efalizumab, a Humanized Anti‐CD11a, Anti‐LFA‐1 in Renal Transplantation by Vincenti, F., Mendez, R., Pescovitz, M., Rajagopalan, P. R., Wilkinson, A. H., Butt, K., Laskow, D., Slakey, D. P., Lorber, M. I., Garg, J. P., Garovoy, M.

“…Leukocyte function associated antigen‐1 (LFA‐1) has a multifaceted role in the immune response, including adhesion and trafficking of leukocytes, stabilizing…”
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A Novel Targeted T-Cell Modulator, Efalizumab, for Plaque Psoriasis by Lebwohl, Mark, Tyring, Stephen K, Hamilton, Tiffani K, Toth, Darryl, Glazer, Scott, Tawfik, Naji H, Walicke, Patricia, Dummer, Wolfgang, Wang, Xiaolin, Garovoy, Marvin R, Pariser, David

“…Leukocyte-function–associated antigen type 1 (LFA-1) is involved in the pathogenesis of psoriasis. Efalizumab is a humanized monoclonal antibody that binds to…”
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Population pharmacokinetics and pharmacodynamics of the anti-CD11a antibody hu1124 in human subjects with psoriasis by Bauer, R J, Dedrick, R L, White, M L, Murray, M J, Garovoy, M R

“…The pharmacokinetics of hu1124, a human anti-CD11a antibody, were investigated in human subjects with psoriasis. CD11a is a subunit of LFA-1, a cell surface…”
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HLA class II antigen associations help to define two types of alopecia areata by COLOMBE, B. W, PRICE, V. H, KHOURY, E. L, GAROVOY, M. R, LOU, C. D

“…Multiple HLA class I and class II antigen associations have been described for alopecia areata (AA). As in other immune-mediated diseases, the HLA antigens…”
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The treatment of moderate to severe psoriasis with a new anti-CD11a monoclonal antibody by Papp, Kim, Bissonnette, Robert, Krueger, James G., Carey, Wayne, Gratton, David, Gulliver, Wayne P., Lui, Harvey, Lynde, Charles W., Magee, Anna, Minier, Daniel, Ouellet, Jean P., Patel, Piyush, Shapiro, Jerry, Shear, Neil H., Kramer, Susan, Walicke, Patricia, Bauer, Robert, Dedrick, Russell L., Kim, Sun Sook, White, Mark, Garovoy, Marvin R.

“…Background: Anti-CD11a (hu1124) is a humanized monoclonal antibody directed against the CD11a subunit of LFA-1. This study investigated whether treatment with…”
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Thrombin stimulates c-sis gene expression in microvascular endothelial cells by Daniel, T O, Gibbs, V C, Milfay, D F, Garovoy, M R, Williams, L T

“…We have determined whether expression of the c-sis gene product, platelet-derived growth factor (PDGF), is regulated in cultured renal microvascular…”
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IL-4 inhibits IL-2 receptor expression and IL-2-dependent proliferation of human T cells by Martinez, OM, Gibbons, RS, Garovoy, MR, Aronson, FR

“…Recent studies have shown that IL-4 can affect lymphocyte responses to IL-2. To evaluate the effects of IL-4 on T cell responses to physiologically relevant…”
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Genetic Regulation of Amifampridine Phosphate (Firdapse(R)) Metabolism Produces Significant Differences in Pharmacokinetics and Side Effects (P04.095) by Haroldsen, P., Garovoy, M.

“…Abstract only…”
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Successful immunomodulation with intravenous gamma globulin and cyclophosphamide in an alloimmunized heart transplant recipient by De Marco, T, Damon, L E, Colombe, B, Keith, F, Chatterjee, K, Garovoy, M R

“…A highly human leukocyte antigen-sensitized heart transplant candidate underwent immunomodulation with intravenous gamma globulin and cyclophosphamide. His…”
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Characteristics of Oligonucleotide Uptake in Human Keratinocyte Cultures by Noonberg, Sarah B, Garovoy, Marvin R, Hunt, C Anthony

“…Oligodeoxyribonucleotides have the potential to interfere selectivity with cellular protein synthesis by sequence-specific hybridization to DNA or RNA…”
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Cytokine and T cell receptor gene expression at the site of allograft rejection by Krams, S M, Falco, D A, Villanueva, J C, Rabkin, J, Tomlanovich, S J, Vincenti, F, Amend, W J, Melzer, J, Garovoy, M R, Roberts, J P

“…Intragraft cytokine and T cell receptor gene expression was analyzed in rejecting renal allografts by polymerase chain reaction (PCR). Message for IL-1 beta,…”
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Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration by Gupta, S K, Manfro, R C, Tomlanovich, S J, Gambertoglio, J G, Garovoy, M R, Benet, L Z

“…The pharmacokinetics of cyclosporine were studied in healthy subjects following administration of cyclosporine both orally (10 mg kg-1) and intravenously (4 mg…”
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Flow cytometry crossmatching as a predictor of acute rejection in sensitized recipients of cadaveric renal transplants by O'rourke, Robert W, Osorio, Robert W, Freise, Chris E, Lou, Calvin D, Garovoy, Marvin R, Bacchetti, Peter, Ascher, Nancy L, Melzer, Juliet S, Roberts, John P, Stock, Peter G

“…Flow cytometry crossmatching (FCXM) was developed as a more sensitive assay than the standard complement‐dependent cytotoxicity crossmatch (CDCXM) for the…”
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The use of intravenous immunoglobulin in recurrent pregnancy loss associated with combined alloimmune and autoimmune abnormalities by Kiprov, D D, Nachtigall, R D, Weaver, R C, Jacobson, A, Main, E K, Garovoy, M R

“…Several studies have evaluated the effect of intravenous gammaglobulin (IVIG) in women with unexplained recurrent spontaneous abortions (RSA). Data regarding…”
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Direct evidence for in vivo induction of CD8+ cytotoxic T cells directed to donor MHC class I peptides following mouse allotransplantation by Popov, I A, Fedoseyeva, E V, Orr, P L, Garovoy, M R, Benichou, G

“…There is accumulating evidence indicating that the T cell response to donor major histocompatibility complex (MHC) peptides plays a crucial role in graft…”
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Identification of high- and low-risk second kidney grafts by MAHONEY, R. J, NORMAN, D. J, COLOMBE, B. W, GAROVOY, M. R, LEEBER, D. A

“…The purpose of this study was to identify recipients who are at low or high risk of early cadaveric regraft failure by segregating results of the flow…”
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Induction of T cell responses to a self-antigen following allotransplantation by FEDOSEYEVA, E. V, TAM, R. C, POPOV, I. A, ORR, P. L, GAROVOY, M. R, BENICHOU, G

“…T cell tolerance to self-antigens is established through the recognition by immature T cells of dominant self-peptides presented in association with self-MHC…”
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Long-term engraftment following in utero T cell-depleted parental marrow transplantation into fetal rhesus monkeys by Cowan, M J, Tarantal, A F, Capper, J, Harrison, M, Garovoy, M

“…A major concern with allogeneic BMT for treating most inherited diseases is the need to overcome graft rejection with conditioning chemotherapy which is…”
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Anti-CD11a treatment for psoriasis concurrently increases circulating T-cells and decreases plaque T-cells, consistent with inhibition of cutaneous T-cell trafficking by Krueger, J., Gottlieb, A., Miller, B., Dedrick, R., Garovoy, M., Walicke, P.

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An oligonucleotide blocks interferon-γ signal transduction by LEE, P. P, RAMANATHAN, M, HUNT, C. A, GAROVOY, M. R

“…Interferon (IFN)-gamma is an important mediator of transplant graft rejection. It induces endothelial cell expression of HLA-DR and intercellular adhesion…”
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