Search Results - "Garnham, Alexandra L."

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis by Sidwell, Tom, Liao, Yang, Garnham, Alexandra L., Vasanthakumar, Ajithkumar, Gloury, Renee, Blume, Jonas, Teh, Peggy P., Chisanga, David, Thelemann, Christoph, de Labastida Rivera, Fabian, Engwerda, Christian R., Corcoran, Lynn, Kometani, Kohei, Kurosaki, Tomohiro, Smyth, Gordon K., Shi, Wei, Kallies, Axel

“…Differentiation and homeostasis of Foxp3 + regulatory T (Treg) cells are strictly controlled by T-cell receptor (TCR) signals; however, molecular mechanisms…”
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The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal by Yang, Yuqing, Kueh, Andrew J., Grant, Zoe L., Abeysekera, Waruni, Garnham, Alexandra L., Wilcox, Stephen, Hyland, Craig D., Di Rago, Ladina, Metcalf, Don, Alexander, Warren S., Coultas, Leigh, Smyth, Gordon K., Voss, Anne K., Thomas, Tim

“…The histone acetyltransferase HBO1 (MYST2, KAT7) is indispensable for postgastrulation development, histone H3 lysine 14 acetylation (H3K14Ac), and the…”
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The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues by Vasanthakumar, Ajithkumar, Liao, Yang, Teh, Peggy, Pascutti, Maria F., Oja, Anna E., Garnham, Alexandra L., Gloury, Renee, Tempany, Jessica C., Sidwell, Tom, Cuadrado, Eloy, Tuijnenburg, Paul, Kuijpers, Taco W., Lalaoui, Najoua, Mielke, Lisa A., Bryant, Vanessa L., Hodgkin, Philip D., Silke, John, Smyth, Gordon K., Nolte, Martijn A., Shi, Wei, Kallies, Axel

“…After exiting the thymus, Foxp3+ regulatory T (Treg) cells undergo further differentiation in the periphery, resulting in the generation of mature, fully…”
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Transcriptional modification of host cells harboring Toxoplasma gondii bradyzoites prevents IFN gamma-mediated cell death by Seizova, Simona, Ruparel, Ushma, Garnham, Alexandra L., Bader, Stefanie M., Uboldi, Alessandro D., Coffey, Michael J., Whitehead, Lachlan W., Rogers, Kelly L., Tonkin, Christopher J.

“…Toxoplasma gondii develops a latent infection in the muscle and central nervous system that acts as a reservoir for acute-stage reactivation in vulnerable…”
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Extracellular Vesicles in Synovial Fluid from Rheumatoid Arthritis Patients Contain miRNAs with Capacity to Modulate Inflammation by Foers, Andrew D., Garnham, Alexandra L., Chatfield, Simon, Smyth, Gordon K., Cheng, Lesley, Hill, Andrew F., Wicks, Ian P., Pang, Ken C.

“…In rheumatoid arthritis (RA), extracellular vesicles (EVs) are associated with both the propagation and attenuation of joint inflammation and destruction…”
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Multi-level remodelling of chromatin underlying activation of human T cells by Bediaga, Naiara G., Coughlan, Hannah D., Johanson, Timothy M., Garnham, Alexandra L., Naselli, Gaetano, Schröder, Jan, Fearnley, Liam G., Bandala-Sanchez, Esther, Allan, Rhys S., Smyth, Gordon K., Harrison, Leonard C.

“…Remodelling of chromatin architecture is known to regulate gene expression and has been well characterized in cell lineage development but less so in response…”
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Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis by Potts, Margaret A., Mizutani, Shinsuke, Garnham, Alexandra L., Li Wai Suen, Connie S. N., Kueh, Andrew J., Tai, Lin, Pal, Martin, Strasser, Andreas, Herold, Marco J.

“…Many lymphoid malignancies arise from deregulated c-MYC expression in cooperation with additional genetic lesions. While many of these cooperative genetic…”
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Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest by Wichmann, Johannes, Pitt, Catherine, Eccles, Samantha, Garnham, Alexandra L., Li-Wai-Suen, Connie S. N., May, Rose, Allan, Elizabeth, Wilcox, Stephen, Herold, Marco J., Smyth, Gordon K., Monahan, Brendon J., Thomas, Tim, Voss, Anne K.

“…Histone acetylation is essential for initiating and maintaining a permissive chromatin conformation and gene transcription. Dysregulation of histone…”
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Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever by Ioannidis, Lisa J, Studniberg, Stephanie I, Eriksson, Emily M, Suwarto, Suhendro, Denis, Dionisius, Liao, Yang, Shi, Wei, Garnham, Alexandra L, Sasmono, R Tedjo, Hansen, Diana S

“…Typical symptoms of uncomplicated dengue fever (DF) include headache, muscle pains, rash, cough, and vomiting. A proportion of cases progress to severe dengue…”
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Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria by Studniberg, Stephanie I, Ioannidis, Lisa J, Utami, Retno A S, Trianty, Leily, Liao, Yang, Abeysekera, Waruni, Li‐Wai‐Suen, Connie S N, Pietrzak, Halina M, Healer, Julie, Puspitasari, Agatha M, Apriyanti, Dwi, Coutrier, Farah, Poespoprodjo, Jeanne R, Kenangalem, Enny, Andries, Benediktus, Prayoga, Pak, Sariyanti, Novita, Smyth, Gordon K, Cowman, Alan F, Price, Ric N, Noviyanti, Rintis, Shi, Wei, Garnham, Alexandra L, Hansen, Diana S

“…Clinical immunity to P. falciparum malaria is non‐sterilizing, with adults often experiencing asymptomatic infection. Historically, asymptomatic malaria has…”
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Genome-wide analysis reveals no evidence of trans chromosomal regulation of mammalian immune development by Johanson, Timothy M, Coughlan, Hannah D, Lun, Aaron T L, Bediaga, Naiara G, Naselli, Gaetano, Garnham, Alexandra L, Harrison, Leonard C, Smyth, Gordon K, Allan, Rhys S

“…It has been proposed that interactions between mammalian chromosomes, or transchromosomal interactions (also known as kissing chromosomes), regulate gene…”
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Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7 by Kueh, Andrew J., Bergamasco, Maria I., Quaglieri, Anna, Phipson, Belinda, Li-Wai-Suen, Connie S.N., Lönnstedt, Ingrid M., Hu, Yifang, Feng, Zhi-Ping, Woodruff, Chris, May, Rose E., Wilcox, Stephen, Garnham, Alexandra L., Snyder, Michael P., Smyth, Gordon K., Speed, Terence P., Thomas, Tim, Voss, Anne K.

“…In the conventional model of transcriptional activation, transcription factors bind to response elements and recruit co-factors, including histone…”
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A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection by Preston, Simon P., Allison, Cody C., Schaefer, Jan, Clow, William, Bader, Stefanie M., Collard, Sophie, Forsyth, Wasan O., Clark, Michelle P., Garnham, Alexandra L., Li-Wai-Suen, Connie S. N., Peiris, Thanushi, Teale, Jack, Mackiewicz, Liana, Davidson, Sophia, Doerflinger, Marcel, Pellegrini, Marc

“…Necroptosis is a lytic and inflammatory form of cell death that is highly constrained to mitigate detrimental collateral tissue damage and impaired immunity…”
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Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a by Shields, Benjamin J, Jackson, Jacob T, Metcalf, Donald, Shi, Wei, Huang, Qiutong, Garnham, Alexandra L, Glaser, Stefan P, Beck, Dominik, Pimanda, John E, Bogue, Clifford W, Smyth, Gordon K, Alexander, Warren S, McCormack, Matthew P

“…Unlike clustered HOX genes, the role of nonclustered homeobox gene family members in hematopoiesis and leukemogenesis has not been extensively studied. Here we…”
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Small Extracellular Vesicle Enrichment of a Retrotransposon-Derived Double-Stranded RNA: A Means to Avoid Autoinflammation? by Barrios, Marilou H., Garnham, Alexandra L., Foers, Andrew D., Cheng-Sim, Lesley, Masters, Seth L., Pang, Ken C.

“…Small extracellular vesicles (SEVs) such as exosomes are released by multiple cell types. Originally believed to be a mechanism for selectively removing…”
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Blood transcriptomics identifies immune signatures indicative of infectious complications in childhood cancer patients with febrile neutropenia by Haeusler, Gabrielle M, Garnham, Alexandra L, Li‐Wai‐Suen, Connie SN, Clark, Julia E, Babl, Franz E, Allaway, Zoe, Slavin, Monica A, Mechinaud, Francoise, Smyth, Gordon K, Phillips, Bob, Thursky, Karin A, Pellegrini, Marc, Doerflinger, Marcel

“…Objectives Febrile neutropenia (FN) is a major cause of treatment disruption and unplanned hospitalization in childhood cancer patients. This study…”
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The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity by Seillet, Cyril, Luong, Kylie, Tellier, Julie, Jacquelot, Nicolas, Shen, Rui Dong, Hickey, Peter, Wimmer, Verena C., Whitehead, Lachlan, Rogers, Kelly, Smyth, Gordon K., Garnham, Alexandra L., Ritchie, Matthew E., Belz, Gabrielle T.

“…Group 3 innate lymphoid cell (ILC3)-mediated production of the cytokine interleukin-22 (IL-22) is critical for the maintenance of immune homeostasis in the…”
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Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer by Best, Sarah A., Gubser, Patrick M., Sethumadhavan, Shalini, Kersbergen, Ariena, Negrón Abril, Yashira L., Goldford, Joshua, Sellers, Katherine, Abeysekera, Waruni, Garnham, Alexandra L., McDonald, Jackson A., Weeden, Clare E., Anderson, Dovile, Pirman, David, Roddy, Thomas P., Creek, Darren J., Kallies, Axel, Kingsbury, Gillian, Sutherland, Kate D.

“…The tumor microenvironment (TME) contains a rich source of nutrients that sustains cell growth and facilitate tumor development. Glucose and glutamine in the…”
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Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy by Thijssen, Rachel, Tian, Luyi, Anderson, Mary Ann, Flensburg, Christoffer, Jarratt, Andrew, Garnham, Alexandra L., Jabbari, Jafar S., Peng, Hongke, Lew, Thomas E., Teh, Charis E., Gouil, Quentin, Georgiou, Angela, Tan, Tania, Djajawi, Tirta M., Tam, Constantine S., Seymour, John F., Blombery, Piers, Gray, Daniel H.D., Majewski, Ian J., Ritchie, Matthew E., Roberts, Andrew W., Huang, David C.S.

“…•Multiple independent but recurring genetic and epigenetic changes drive venetoclax resistance, with marked NF-κB activation ubiquitous.•NF-κB activation is…”
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