Search Results - "Garnett, William R"

Diazepam autoinjector intramuscular delivery system versus diazepam rectal gel: A pharmacokinetic comparison by Garnett, William R, Barr, William H, Edinboro, Leslie E, Karnes, H. Thomas, Mesa, Mike, Wannarka, Gerald L

“…Summary Rectal administration of diazepam (DZ) has been used effectively in patients with epilepsy who experience acute repetitive seizures, but rectal gel may…”
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Optimizing Antiepileptic Drug Therapy in the Elderly by Garnett, William R

“…OBJECTIVE To review and evaluate the medical literature concerning antiepileptic drug (AED) therapy in elderly patients. DATA SOURCES A MEDLINE search…”
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Lansoprazole: a proton pump inhibitor by Garnett, W R

“…To summarize the published data on lansoprazole, a proton pump inhibitor approved by the Food and Drug Administration for use in the treatment of duodenal…”
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Evaluation of the Effect of Ammonia on Nicotine Pharmacokinetics Using Rapid Arterial Sampling by McKinney, Diana L., Gogova, Maria, Davies, Bruce D., Ramakrishnan, Viswanathan, Fisher, Kelly, Carter, W. Hans, Karnes, H. Thomas, Garnett, William R., Iyer, Sunil S., Somani, Amit A., Kobal, Gerd, Barr, William H.

“…The nicotine bolus theory states that the dependence-producing potential of cigarettes relates to a rapid increase in nicotine at brain receptor sites. It has…”
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Lamotrigine: pharmacokinetics by Garnett, W R

“…The pharmacokinetics of lamotrigine have been studied in single and multiple dose studies in animals, normal volunteers, and patients with epilepsy…”
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Carbamazepine extended-release capsules vs. oxcarbazepine: computer simulations of the effect of missed doses on drug plasma concentrations by Ahmad, Alaa, Garnett, William R.

“…ABSTRACT Objective: Plasma concentrations of antiepileptic drugs (AEDs) can vary and are not always an indication of clinical utility. However, adverse event…”
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Transitional Polytherapy: Tricks of the Trade for Monotherapy to Monotherapy AED Conversions by Garnett, William R, St Louis, Erik K, Henry, Thomas R, Bramley, Thomas

“…The goal of epilepsy therapy is to help patients achieve seizure freedom without adverse effects. While monotherapy is preferable in epilepsy treatment, many…”
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History of Acid Suppression: Focus on the Hospital Setting by Garnett, William R.

“…In the hospital setting, prophylactic acid suppression is an important part of care for many critically ill patients. It may also prevent rebleeding in…”
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Clinical Implications of Drug Interactions with Coxibs by Garnett, William R.

“…Nonsteroidal antiinflammatory drugs (NSAIDs) often are prescribed to patients who are taking concomitant drugs. Cyclooxygenase (COX)‐2 inhibitors (coxibs)…”
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Conversions between monotherapies in epilepsy: Expert consensus by St. Louis, Erik K, Gidal, Barry E, Henry, Thomas R, Kaydanova, Yevgenya, Krumholz, Allan, McCabe, Paul H, Montouris, Georgia D, Rosenfeld, William E, Smith, Brien J, Stern, John M, Waterhouse, Elizabeth J, Schulz, Richard M, Garnett, William R, Bramley, Thomas

“…Abstract To develop expert consensus for conversion between antiepileptic drug (AED) monotherapies, an 11-member panel used the Delphi Technique over three…”
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Rapid automated blood sampling system for pharmacokinetics studies of cigarette smoking by McKinney, Diana L., Davies, Bruce D., Gogova, Maria, Adams, William M., Lewis, Wayne, Powell, Chad, Iyer, Sunil S., Garnett, William R., Karnes, H. Thomas, Kobal, Gerd, Barr, William H.

“…We developed an automated sampling system to allow multiple, discrete blood samples from a human participant to be collected rapidly and immediately following…”
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Patterns of care, outcomes, and direct health plan costs of antiepileptic therapy: a pharmacoeconomic analysis of the available carbamazepine formulations by Garnett, William R., Gilbert, Thomas D., O'Connor, Paul

“…Abstract Although generic formulations of immediate-release carbamazepine (IR-CBZ) are available, extended-release delivery systems may offer important…”
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Lack of a Clinically Significant Effect of Zonisamide on Phenytoin Steady-State Pharmacokinetics in Patients With Epilepsy by Levy, René H., Ragueneau-Majlessi, Isabelle, Garnett, William R., Schmerler, Michael, Rosenfeld, William, Shah, Jaymin, Pan, Wei-Jian

“…This study was designed to measure the effect of the addition of zonisamide on phenytoin pharmacokinetics under steady‐state conditions in patients with…”
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Simulated fluctuations in plasma drug concentrations for patients receiving oxcarbazepine or carbamazepine extended-release capsules by Ahmad, Alaa, Garnett, William R

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Tolerability and effects on quality of life of twice-daily extended-release carbamazepine in adults with seizure disorders: An open-label, 12- to 36-month continuation study by Edward Hogan, R, Garnett, William R, Thadani, Vijay M

“…Background: An earlier 6-month, multicenter, open-label study in patients with complex partial seizures found that a switch from multiple daily doses of…”
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The use of Monte Carlo simulations to study the effect of poor compliance on the steady state concentrations of valproic acid following administration of enteric-coated and extended release divalproex sodium formulations by Ahmad, Alaa M., Douglas Boudinot, F., Barr, William H., Reed, Ronald C., Garnett, William R.

“…Divalproex sodium extended‐release (Depakote® ER) is a once daily (QD) formulation for valproic acid that was developed to improve patient compliance and to…”
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Simulation of the effect of patient nonadherence on plasma concentrations of carbamazepine from twice-daily extended-release capsules by Garnett, William R., McLean, Angus M., Zhang, Yuxin, Clausen, Susan, Tulloch, Simon J.

“…SUMMARY Objective: Carbamazepine (CBZ) effectively treats simple, complex, and secondarily generalized partial seizures. Computer simulations were carried out…”
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Treatment of Crohn's disease with infliximab by Garnett, WR, Yunker, N

“…The role of infliximab in managing Crohn's disease (CD) is described. CD is characterized by chronic transmural inflammation at various sites of the…”
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Pharmacist Impact on Posttraumatic Seizure Prophylaxis in Patients with Head Injury by Brophy, Gretchen M., Tesoro, Eljim P., Schrote, Gretchen L., Garnett, William R.

“…Phenytoin is the most commonly administered antiepileptic agent for the prevention of early (≤ 7 days) posttraumatic seizures. Use of the agent, however,…”
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Pharmacokinetic Evaluation of Twice‐Daily Extended‐Release Carbamazepine (CBZ) and Four‐Times‐Daily Immediate‐Release CBZ in Patients with Epilepsy by Garnett, William R., Levy, Benjamin, McLean, Angus M., Zhang, Yuxin, Couch, Richard A., Rudnic, Edward M., Pellock, John M., Belendiuk, George W.

“…Purpose: A new capsule dosage form of carbamazepine (CBZ) has been developed, consisting of three different types of beads (immediate‐release,…”
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