Search Results - "Garnett, C E"

Improving the Assessment of Heart Toxicity for All New Drugs Through Translational Regulatory Science by Johannesen, L, Vicente, J, Gray, R A, Galeotti, L, Loring, Z, Garnett, C E, Florian, J, Ugander, M, Stockbridge, N, Strauss, D G

“…Fourteen drugs have been removed from the market worldwide because they cause torsade de pointes. Most drugs that cause torsade can be identified by assessing…”
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Boosting Solar Cell Photovoltage via Nanophotonic Engineering by Cui, Y, van Dam, D, Mann, S. A, van Hoof, N. J. J, van Veldhoven, P. J, Garnett, E. C, Bakkers, E. P. A. M, Haverkort, J. E. M

“…Approaching the theoretically limiting open circuit voltage (V oc) of solar cells is crucial to optimize their photovoltaic performance. Here, we demonstrate…”
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Growth and Electrical Characteristics of Platinum-Nanoparticle-Catalyzed Silicon Nanowires by Garnett, E. C., Liang, W., Yang, P.

“…Pt nanoparticle catalysts are used to synthesize Si nanowires. The standard deviations of the starting colloid and the resulting wire diameters are essentially…”
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A Modeling and Simulation Approach to Characterize Methadone QT Prolongation Using Pooled Data From Five Clinical Trials in MMT Patients by Florian, J, Garnett, C E, Nallani, S C, Rappaport, B A, Throckmorton, D C

“…Pharmacokinetic (PK)‐pharmacodynamic modeling and simulation were used to establish a link between methadone dose, concentrations, and Fridericia…”
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Effects of Nafion as a binding agent for unsupported nanoparticle catalysts by McGovern, M.S., Garnett, E.C., Rice, C., Masel, R.I., Wieckowski, A.

“…We studied the effect of Nafion on the formic acid oxidation reactivity of three unsupported nanoparticle catalysts: Pt black, Pt/Ru black, and Pt/Pd. The…”
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Au-Cu2O core-shell nanowire photovoltaics by Oener, S. Z., Mann, S. A., Sciacca, B., Sfiligoj, C., Hoang, J., Garnett, E. C.

“…Semiconductor nanowires are among the most promising candidates for next generation photovoltaics. This is due to their outstanding optical and electrical…”
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Methodologies to characterize the QT/corrected QT interval in the presence of drug-induced heart rate changes or other autonomic effects by Garnett, Christine E., PharmD, Zhu, Hao, PhD, Malik, Marek, MD, PhD, Fossa, Anthony A., PhD, Zhang, Joanne, PhD, Badilini, Fabio, PhD, Li, Jianguo, PhD, Darpö, Börje, MD, PhD, Sager, Philip, MD, Rodriguez, Ignacio, MD

“…This White Paper, written collaboratively by members of the Cardiac Safety Research Consortium from academia, industry, and regulatory agencies, discusses…”
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Hybrid Silicon Nanocone–Polymer Solar Cells by Jeong, Sangmoo, Garnett, Erik C, Wang, Shuang, Yu, Zongfu, Fan, Shanhui, Brongersma, Mark L, McGehee, Michael D, Cui, Yi

“…Recently, hybrid Si/organic solar cells have been studied for low-cost Si photovoltaic devices because the Schottky junction between the Si and organic…”
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Au-Cu{sub 2}O core-shell nanowire photovoltaics by Oener, S. Z., Mann, S. A., Sciacca, B., Sfiligoj, C., Hoang, J., Garnett, E. C.

“…Semiconductor nanowires are among the most promising candidates for next generation photovoltaics. This is due to their outstanding optical and electrical…”
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Different Anesthetic Sensitivities of Skeletal and Cardiac Isoforms of the Ca-ATPase by Karon, Brad S, Autry, Joseph M, Shi, Yongli, Garnett, Christine E, Inesi, Giuseppe, Jones, Larry R, Kutchai, Howard, Thomas, David D

“…We have previously shown that low levels of the volatile anesthetic halothane activate the Ca-ATPase in skeletal sarcoplasmic reticulum (SR), but inhibit the…”
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Population Pharmacokinetic and Concentration-QTc Models for Moxifloxacin: Pooled Analysis of 20 Thorough QT Studies by Florian, Jeffry A., Tornøe, Christoffer W., Brundage, Richard, Parekh, Ameeta, Garnett, Christine E.

“…To increase our understanding of important subject characteristics and design variables affecting the performance of oral moxifloxacin in thorough QT studies,…”
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Are women more susceptible than men to drug‐induced QT prolongation? Concentration–QTc modelling in a phase 1 study with oral rac‐sotalol by Darpo, Borje, Karnad, Dilip R., Badilini, Fabio, Florian, Jeff, Garnett, Christine E, Kothari, Snehal, Panicker, Gopi Krishna, Sarapa, Nenad

“…Aim To study the differences in QTc interval on ECG in response to a single oral dose of rac‐sotalol in men and women. Methods Continuous 12‐lead ECGs were…”
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Concentration-QT Relationships Play a Key Role in the Evaluation of Proarrhythmic Risk During Regulatory Review by Garnett, Christin E., Beasley, Nhi, Bhattaram, V. Atul, Jadhav, Pravi R., Madabushi, Rajanikanth, Stockbridge, Norman, Tornøe, Christoffe W., Wang, Yaning, Zhu, Hao, Gobburu, Jogara V.

“…The criterion for assessing whether a drug prolongs QT as described in the International Conference on Harmonization topic E14 guideline does not explicitly…”
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Creation of a Knowledge Management System for QT Analyses by Tornøe, Christoffer W., Garnett, Christine E., Wang, Yaning, Florian, Jeffry, Li, Michael, Gobburu, Jogarao V.

“…An increasing number of thorough QT (TQT) reports are being submitted to the US Food and Drug Administration's interdisciplinary review team for QT (IRT‐QT),…”
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Silicon nanowire hybrid photovoltaics by Garnett, E C, Peters, C, Brongersma, M, Yi Cui, McGehee, M

“…Silicon nanowire Schottky junction solar cells have been fabricated using n-type silicon nanowire arrays and a spin-coated conductive polymer (PEDOT). The…”
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A novel method to assess test-quality of phase-3 trials by Garnett, C. E., Nelson, J., Peck, C.

“…Objectives To investigate new drug development programs, we piloted a method to assess “test‐quality” of phase‐3 trials. Methods. 40 phase‐3 trial results,…”
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The relative importance of between subject correlation of clearance (CL) and volume of distribution (V) compared with correlation of estimation error when applied to pharmacokinetic (PK) simulation by Garnett, C. E., Holford, N. H.

“…Purpose To describe the bias and imprecision of t1/2 when CL and V are simulated with and without correlations in the random effects (PPV) and standard errors…”
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Phase-resolved surface plasmon scattering probed by cathodoluminescence holography by Schilder, N. J, Agrawal, H, Garnett, E. C, Polman, A

“…High-energy (1-100 keV) electrons can coherently couple to plasmonic and dielectric nanostructures creating cathodoluminescence (CL) of which the spectral…”
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Are women more susceptible than men to drug-induced QT prolongation? Concentration-QT c modelling in a phase 1 study with oral rac-sotalol by Darpo, B, Karnad, DR, Badilini, F, Florian, J, Garnett, CE, Kothari, S, Panicker, GK, Sarapa, N

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Considerations for Clinical Trial Design and Data Analyses of Thorough QT Studies Using Drug-Drug Interaction by Zhu, Hao, Wang, Yaning, Gobburu, Jogarao V., Garnett, Christine E.

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