Search Results - "Garner, Omai"

Clinical Impact of Metagenomic Next-Generation Sequencing of Plasma Cell-Free DNA for the Diagnosis of Infectious Diseases: A Multicenter Retrospective Cohort Study by Hogan, Catherine A, Yang, Shangxin, Garner, Omai B, Green, Daniel A, Gomez, Carlos A, Dien Bard, Jennifer, Pinsky, Benjamin A, Banaei, Niaz

“…Abstract Background Metagenomic next-generation sequencing (mNGS) of plasma cell-free DNA has emerged as an attractive diagnostic modality allowing broad-range…”
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Cellphone-Based Hand-Held Microplate Reader for Point-of-Care Testing of Enzyme-Linked Immunosorbent Assays by Berg, Brandon, Cortazar, Bingen, Tseng, Derek, Ozkan, Haydar, Feng, Steve, Wei, Qingshan, Chan, Raymond Yan-Lok, Burbano, Jordi, Farooqui, Qamar, Lewinski, Michael, Di Carlo, Dino, Garner, Omai B, Ozcan, Aydogan

“…Standard microplate based enzyme-linked immunosorbent assays (ELISA) are widely utilized for various nanomedicine, molecular sensing, and disease screening…”
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Highly Stable and Sensitive Nucleic Acid Amplification and Cell-Phone-Based Readout by Kong, Janay E, Wei, Qingshan, Tseng, Derek, Zhang, Jingzi, Pan, Eric, Lewinski, Michael, Garner, Omai B, Ozcan, Aydogan, Di Carlo, Dino

“…Key challenges with point-of-care (POC) nucleic acid tests include achieving a low-cost, portable form factor, and stable readout, while also retaining the…”
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Galectin-glycan lattices regulate cell-surface glycoprotein organization and signalling by Garner, Omai B, Baum, Linda G

“…The formation of multivalent complexes of soluble galectins with glycoprotein receptors on the plasma membrane helps to organize glycoprotein assemblies on the…”
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Clinical Whole Genome Sequencing for Clarithromycin and Amikacin Resistance Prediction and Subspecies Identification of Mycobacterium abscessus by Realegeno, Susan, Mirasol, Ruel, Garner, Omai B., Yang, Shangxin

“…Mycobacterium abscessus infections are an emerging health care concern in patients with chronic pulmonary diseases, leading to high morbidity and mortality…”
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Randomized Trial Evaluating Clinical Impact of RAPid IDentification and Susceptibility Testing for Gram-negative Bacteremia: RAPIDS-GN by Banerjee, Ritu, Komarow, Lauren, Virk, Abinash, Rajapakse, Nipunie, Schuetz, Audrey N, Dylla, Brenda, Earley, Michelle, Lok, Judith, Kohner, Peggy, Ihde, Sherry, Cole, Nicolynn, Hines, Lisa, Reed, Katelyn, Garner, Omai B, Chandrasekaran, Sukantha, de St. Maurice, Annabelle, Kanatani, Meganne, Curello, Jennifer, Arias, Rubi, Swearingen, William, Doernberg, Sarah B, Patel, Robin

“…Abstract Background Rapid blood culture diagnostics are of unclear benefit for patients with gram-negative bacilli (GNB) bloodstream infections (BSIs). We…”
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Prospective clinical validation of 3D printed nasopharyngeal swabs for diagnosis of COVID-19 by Oland, Gabriel, Garner, Omai, de St Maurice, Annabelle

“…•Diagnosis of COVID-19 using 3D printed swabs needs prospective validation.•Two 3D printed designs demonstrate high concordance with traditional flocked…”
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Point-of-Care Serodiagnostic Test for Early-Stage Lyme Disease Using a Multiplexed Paper-Based Immunoassay and Machine Learning by Joung, Hyou-Arm, Ballard, Zachary S, Wu, Jing, Tseng, Derek K, Teshome, Hailemariam, Zhang, Linghao, Horn, Elizabeth J, Arnaboldi, Paul M, Dattwyler, Raymond J, Garner, Omai B, Di Carlo, Dino, Ozcan, Aydogan

“…Caused by the tick-borne spirochete Borrelia burgdorferi, Lyme disease (LD) is the most common vector-borne infectious disease in North America and Europe…”
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SARS-CoV-2 Infection Detection by PCR and Serologic Testing in Clinical Practice by Murad, Douglas, Chandrasekaran, Sukantha, Pillai, Ajaya, Garner, Omai B, Denny, Christopher T

“…Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be diagnosed by PCR during acute infection or later in their clinical course by…”
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High-throughput and automated diagnosis of antimicrobial resistance using a cost-effective cellphone-based micro-plate reader by Feng, Steve, Tseng, Derek, Di Carlo, Dino, Garner, Omai B., Ozcan, Aydogan

“…Routine antimicrobial susceptibility testing (AST) can prevent deaths due to bacteria and reduce the spread of multi-drug-resistance, but cannot be regularly…”
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Coinfections of Two Strains of NDM-1- and OXA-232-Coproducing Klebsiella pneumoniae in a Kidney Transplant Patient by Contreras, Deisy A, Fitzwater, Sean P, Nanayakkara, Deepa D, Schaenman, Joanna, Aldrovandi, Grace M, Garner, Omai B, Yang, Shangxin

“…We report here a fatal case of carbapenem-resistant (CRKP) infections in a renal transplant patient without a travel history in the prior year, from whom 2…”
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Validation, Implementation, and Clinical Utility of Whole Genome Sequence-Based Bacterial Identification in the Clinical Microbiology Laboratory by Price, Travis K., Realegeno, Susan, Mirasol, Ruel, Tsan, Allison, Chandrasekaran, Sukantha, Garner, Omai B., Yang, Shangxin

“…The application of next-generation sequencing extends from microbial identification to epidemiologic insight and antimicrobial resistance prediction. Despite…”
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Differential DNA accessibility to polymerase enables 30-minute phenotypic β-lactam antibiotic susceptibility testing of carbapenem-resistant Enterobacteriaceae by Schoepp, Nathan G, Liaw, Eric J, Winnett, Alexander, Savela, Emily S, Garner, Omai B, Ismagilov, Rustem F

“…The rise in carbapenem-resistant Enterobacteriaceae (CRE) infections has created a global health emergency, underlining the critical need to develop faster…”
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Deep Learning-Enhanced Paper-Based Vertical Flow Assay for High-Sensitivity Troponin Detection Using Nanoparticle Amplification by Han, Gyeo-Re, Goncharov, Artem, Eryilmaz, Merve, Joung, Hyou-Arm, Ghosh, Rajesh, Yim, Geon, Chang, Nicole, Kim, Minsoo, Ngo, Kevin, Veszpremi, Marcell, Liao, Kun, Garner, Omai B., Di Carlo, Dino, Ozcan, Aydogan

“…Successful integration of point-of-care testing (POCT) into clinical settings requires improved assay sensitivity and precision to match laboratory standards…”
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Amphiphilic Particle-Stabilized Nanoliter Droplet Reactors with a Multimodal Portable Reader for Distributive Biomarker Quantification by Shah, Vishwesh, Yang, Xilin, Arnheim, Alyssa, Udani, Shreya, Tseng, Derek, Luo, Yi, Ouyang, Mengxing, Destgeer, Ghulam, Garner, Omai B., Koydemir, Hatice C., Ozcan, Aydogan, Di Carlo, Dino

“…Compartmentalization, leveraging microfluidics, enables highly sensitive assays, but the requirement for significant infrastructure for their design, build,…”
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Catabacter hongkongensis bacteremia identified by direct metagenomic sequencing of positive blood culture fluid, first case report in the US by Kamau, Edwin, Maliksi, Enedina, Kwan, Nancy, Garner, Omai B., Yang, Shangxin

“…Catabacter hongkongensis, an increasingly recognized bacteria in clinical samples, was identified by direct metagenomic sequencing of positive blood culture…”
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Accurate subspecies-level identification of clinically significant Mycobacterium avium and Mycobacterium intracellulare by whole-genome sequencing by Chawla, Rachit, Shaw, Bennett, von Bredow, Benjamin, Chong, Cathrine, Garner, Omai B., Zangwill, Kenneth M., Yang, Shangxin

“…Whole genome sequencing (WGS) of Mycobacterium avium complex (MAC) isolates in the clinical laboratory setting allows for rapid and reliable subspecies…”
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FDA trial regulation of laboratory developed tests (LDTs): An academic medical center's experience with Mpox in-house testing by Caldera, JR, Gray, Hannah K., Garner, Omai B., Yang, Shangxin

“…The 2022 mpox outbreak presented a familiar challenge to clinical laboratories. Accordingly, our institution was able to swiftly implement in-house mpox…”
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Clinical and Epidemiologic Evaluation of Inconclusive COVID-19 PCR Results Using a Quantitative Algorithm by Yang, Shangxin, Stanzione, Nicholas, Uslan, Daniel Z, Garner, Omai B, de St Maurice, Annabelle

“…Abstract Objectives The inconclusive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) result causes confusion and…”
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Risk Factors and Outcomes of Mucorales Infection in a Modern Cohort of Solid Organ Transplant, Hematopoietic Cell Transplant, and Chimeric Antigen Receptor T-cell Therapy Recipients by Ogawa, Lauren, Multani, Ashrit, Beaird, Omer E., Gaynor, Pryce, Carlson, Margrit, Garner, Omai B., Schiller, Gary, Schaenman, Joanna M.

“…Mucorales infections continue to cause significant morbidity and mortality in immunocompromised hosts despite the advent of new approaches for diagnosis and…”
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