Differential sensitivities of glioblastoma cell lines towards metabolic and signaling pathway inhibitions

Highlights • The proliferation of GBM cell lines displayed different sensitivities towards oligomycin or 2DG. • Differential sensitivities of GBM cell lines towards oligomycin were correlated with the activation of AMPKα. • Combining oligomycin and 2DG has drastic synergistic effects on suppressing...

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Bibliographic Details
Published in:	Cancer letters Vol. 336; no. 2; pp. 299 - 306
Main Authors:	Kennedy, Colin R, Tilkens, Sarah B, Guan, Hong, Garner, Justine A, Or, Penelope M.Y, Chan, Andrew M
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 19-08-2013 Elsevier Limited
Subjects:	Angiogenesis Apoptosis Cancer therapies Cell Differentiation - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Deoxyglucose - pharmacology Glioblastoma Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glucose Hematology, Oncology and Palliative Medicine Humans Hypoxia Kinases Metabolism Motility Oligomycins - pharmacology Oxidative Phosphorylation - drug effects Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphorylation PI3-K Proteins Signal Transduction - drug effects Tumors Warburg’s effect PI3-K Metabolism Warburg’s effect Glioblastoma
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Summary:	Highlights • The proliferation of GBM cell lines displayed different sensitivities towards oligomycin or 2DG. • Differential sensitivities of GBM cell lines towards oligomycin were correlated with the activation of AMPKα. • Combining oligomycin and 2DG has drastic synergistic effects on suppressing cell growth and motility.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.03.020