Search Results - "Garner, Amanda L."

A Highly Sensitive Fluorescent Sensor for Palladium Based on the Allylic Oxidative Insertion Mechanism by Song, Fengling, Garner, Amanda L, Koide, Kazunori

“…Although palladium catalysts are powerful reagents in organic synthesis, hazardous palladium is often found in reaction products even after purifications…”
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Enhancement of a Catalysis-Based Fluorometric Detection Method for Palladium through Rational Fine-Tuning of the Palladium Species by Garner, Amanda L, Song, Fengling, Koide, Kazunori

“…Metal analyses in chemistry, materials science, and environmental science are currently performed using techniques such as inductively coupled plasma mass…”
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Oxidation State-Specific Fluorescent Method for Palladium(II) and Platinum(IV) Based on the Catalyzed Aromatic Claisen Rearrangement by Garner, Amanda L, Koide, Kazunori

“…Contamination of active pharmaceutical ingredients and healthcare products with oxidized forms of palladium and platinum are important problems. We report a…”
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Inhibitor of MYC identified in a Kröhnke pyridine library by Hart, Jonathan R., Garner, Amanda L., Yu, Jing, Ito, Yoshihiro, Sun, Minghao, Ueno, Lynn, Rhee, Jin-Kyu, Baksh, Michael M., Stefan, Eduard, Hartl, Markus, Bister, Klaus, Vogt, Peter K., Janda, Kim D.

“…In a fluorescence polarization screen for the MYC–MAX interaction, we have identified a novel small-molecule inhibitor of MYC, KJ-Pyr-9, from a Kröhnke…”
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Protein-protein interactions and cancer: targeting the central dogma by Garner, Amanda L, Janda, Kim D

“…Between 40,000 and 200,000 protein-protein interactions have been predicted to exist within the human interactome. As these interactions are of a critical…”
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High-Throughput Platform Assay Technology for the Discovery of pre-microRNA-Selective Small Molecule Probes by Lorenz, Daniel A, Song, James M, Garner, Amanda L

“…MicroRNAs (miRNA) play critical roles in human development and disease. As such, the targeting of miRNAs is considered attractive as a novel therapeutic…”
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cat-ELCCA: A Robust Method To Monitor the Fatty Acid Acyltransferase Activity of Ghrelin O-Acyltransferase (GOAT) by Garner, Amanda L, Janda, Kim D

“…Assays armed with catalytic signal amplification have arisen as superior systems for ultrasensitive detection of analytes. A conceptually new enzyme assay…”
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Fluorescent method for platinum detection in buffers and serums for cancer medicine and occupational hazards by Garner, Amanda L, Koide, Kazunori

“…Herein we demonstrate fluorescence detection of total platinum species in buffers and serums by a Pt(0)-catalyzed Tsuji-Trost type reaction to yield a…”
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Expansion of cat-ELCCA for the Discovery of Small Molecule Inhibitors of the Pre-let-7–Lin28 RNA–Protein Interaction by Lorenz, Daniel A, Kaur, Tanpreet, Kerk, Samuel A, Gallagher, Erin E, Sandoval, Jorge, Garner, Amanda L

“…Dysregulation of microRNA (miRNA) expression has been linked to many human diseases; however, because of the challenges associated with RNA-targeted drug…”
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Repositioning of an existing drug for the neglected tropical disease Onchocerciasis by Gloeckner, Christian, Garner, Amanda L, Mersha, Fana, Oksov, Yelena, Tricoche, Nancy, Eubanks, Lisa M, Lustigman, Sara, Kaufmann, Gunnar F, Janda, Kim D

“…Onchocerciasis, or river blindness, is a neglected tropical disease caused by the filarial nematode Onchocerca volvulus that affects more than 37 million…”
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Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: tropolones as inhibitors of P. aeruginosa elastase by Fullagar, Jessica L, Garner, Amanda L, Struss, Anjali K, Day, Joshua A, Martin, David P, Yu, Jing, Cai, Xiaoqing, Janda, Kim D, Cohen, Seth M

“…Tropolone emerged from the screening of a chelator fragment library (CFL) as an inhibitor of the Zn(2+)-dependent virulence factor, Pseudomonas aeruginosa…”
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Contemporary Progress and Opportunities in RNA-Targeted Drug Discovery by Garner, Amanda L.

“…The surprising discovery that RNAs are the predominant gene products to emerge from the human genome catalyzed a renaissance in RNA biology. It is now…”
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Targeting the Wolbachia cell division protein FtsZ as a new approach for antifilarial therapy by Li, Zhiru, Garner, Amanda L, Gloeckner, Christian, Janda, Kim D, Carlow, Clotilde K

“…The use of antibiotics targeting the obligate bacterial endosymbiont Wolbachia of filarial parasites has been validated as an approach for controlling filarial…”
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MINCR is not a MYC-induced lncRNA by Hart, Jonathan R., Weinberg, Marc S., Morris, Kevin V., Roberts, Thomas C., Janda, Kim D., Garner, Amanda L., Vogt, Peter K.

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Synthesis of 7-benzylguanosine cap-analogue conjugates for eIF4E targeted degradation by Kaur, Tanpreet, Menon, Arya, Garner, Amanda L.

“…Eukaryotic translation initiation factor 4E (eIF4E) is a key player in the initiation of cap-dependent translation through recognition of the m7GpppX cap at…”
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Adaptation of RiPCA for the Live-Cell Detection of mRNA-Protein Interactions by Soueid, Dalia M, Garner, Amanda L

“…RNA-binding proteins (RBPs) act as essential regulators of cell fate decisions, through their ability to bind and regulate the activity of cellular RNAs. For…”
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Stereochemical insignificance discovered in Acinetobacter baumannii quorum sensing by Garner, Amanda L, Kim, Sook Kyung, Zhu, Jie, Struss, Anjali Kumari, Watkins, Richard, Feske, Brent D, Kaufmann, Gunnar F, Janda, Kim D

“…Stereochemistry is a key aspect of molecular recognition for biological systems. As such, receptors and enzymes are often highly stereospecific, only…”
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RNA-targeted drug discovery: moving beyond promiscuous small-molecule scaffolds by L Garner, Amanda

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Optimization of RiPCA for the Live‐Cell Detection of Pre‐MicroRNA‐Protein Interactions by Rosenblum, Sydney L., Garner, Amanda L.

“…Advancements in methods for identifying RNA‐protein interactions (RPIs) on a large scale has necessitated the development of assays for validation of these…”
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Structural Insights into the Advances and Mechanistic Understanding of Human Dicer by Torrez, Rachel M., Ohi, Melanie D., Garner, Amanda L.

“…The RNase III endoribonuclease Dicer was discovered to be associated with cleavage of double-stranded RNA in 2001. Since then, many advances in our…”
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