Search Results - "Garmyn, Marjan"

The Effect of Body Mass Index on Melanoma Biology, Immunotherapy Efficacy, and Clinical Outcomes: A Narrative Review by Jansen, Jente, Garmyn, Marjan, Güvenç, Canan

“…Recent studies indicate that a higher body mass index (BMI) might correlate with improved responses to melanoma treatment, especially with immune checkpoint…”
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Porocarcinoma: Clinical and Histological Features, Immunohistochemistry and Outcomes: A Systematic Review by Bienstman, Thomas, Güvenç, Canan, Garmyn, Marjan

“…Porocarcinoma (PC) is a rare adnexal tumor, mainly found in the elderly. The tumor arises from the acrosyringium of eccrine sweat glands. The risk of lymph…”
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Tumor Vessel Normalization by Chloroquine Independent of Autophagy by Maes, Hannelore, Kuchnio, Anna, Peric, Aleksandar, Moens, Stijn, Nys, Kris, De Bock, Katrien, Quaegebeur, Annelies, Schoors, Sandra, Georgiadou, Maria, Wouters, Jasper, Vinckier, Stefan, Vankelecom, Hugo, Garmyn, Marjan, Vion, Anne-Clémence, Radtke, Freddy, Boulanger, Chantal, Gerhardt, Holger, Dejana, Elisabetta, Dewerchin, Mieke, Ghesquière, Bart, Annaert, Wim, Agostinis, Patrizia, Carmeliet, Peter

“…Chloroquine (CQ) has been evaluated as an autophagy blocker for cancer treatment, but it is unknown if it acts solely by inhibiting cancer cell autophagy. We…”
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Venous thrombotic events in psoriasis patients: a systematic review with meta-analysis by Hillary, Tom, Clijmans, Jolien, Vermeire, Séverine, Lambert, Jo, Garmyn, Marjan, Imbrechts, Maya, Vanassche, Thomas

“…Psoriasis is a chronic inflammatory skin disease associated with numerous comorbidities. Psoriasis has been linked to an increased risk of metabolic syndrome…”
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Autophagy inhibitor chloroquine enhanced the cell death inducing effect of the flavonoid luteolin in metastatic squamous cell carcinoma cells by Verschooten, Lien, Barrette, Kathleen, Van Kelst, Sofie, Rubio Romero, Noemí, Proby, Charlotte, De Vos, Rita, Agostinis, Patrizia, Garmyn, Marjan

“…Flavonoids are widely proposed as very interesting compounds with possible chemopreventive and therapeutic capacities. In this study, we showed that in vitro…”
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Bona Fide Tumor Suppressor Genes Hypermethylated in Melanoma: A Narrative Review by Güvenç, Canan, Neckebroeck, Fien, Antoranz, Asier, Garmyn, Marjan, van den Oord, Joost, Bosisio, Francesca Maria

“…Loss-of-function events in tumor suppressor genes (TSGs) contribute to the development and progression of cutaneous malignant melanoma (CMM). Epigenetic…”
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Impact of the COVID-19 Pandemic on the Incidence and Thickness of Cutaneous Melanoma in Belgium by Demaerel, Philip Georg, Leloup, Arthur, Brochez, Lieve, Van Eycken, Liesbet, Garmyn, Marjan

“…(1) Background: COVID-19 had a major impact on cancer diagnostics and treatment. Delays in diagnosis of cutaneous melanoma were particularly feared, given the…”
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Determinants of 25-hydroxyvitamin D Status in a Cutaneous Melanoma Population by De Smedt, Julie, Van Kelst, Sofie, Janssen, Laudine, Marasigan, Vivien, Boecxstaens, Veerle, Stas, Marguerite, Vanderschueren, Dirk, Guler, Ipek, Bogaerts, Kris, Vandenberghe, Katleen, Bechter, Oliver, Billen, Jaak, Nikkels, Arjen, Strobbe, Tine, Emri, Gabriella, Lambrechts, Diether, Garmyn, Marjan

“…Vitamin D status is influenced by well-known determinants, but factors associated with low 25-hydroxyvitamin D levels in the cutaneous melanoma population are…”
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A Prospective, Monocentric Case-Control Study on Uncontrolled Psoriasis as Independent Risk Factor for a Hypercoagulable State by Hillary, Tom M., Vanhoutvin, Tine, Peeters, Miet, Imbrechts, Maya, Vanassche, Thomas, Garmyn, Marjan, Vermeire, Séverine

“…Introduction Chronic inflammatory diseases, including psoriasis, are associated with development of venous thromboembolism (VTE). The clot lysis profile (CLP)…”
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Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy by Talebi, Ali, de Laat, Vincent, Spotbeen, Xander, Dehairs, Jonas, Rambow, Florian, Rogiers, Aljosja, Vanderhoydonc, Frank, Rizotto, Lara, Planque, Mélanie, Doglioni, Ginevra, Motamedi, Sahar, Nittner, David, Roskams, Tania, Agostinis, Patrizia, Bechter, Oliver, Boecxstaens, Veerle, Garmyn, Marjan, O'Farrell, Marie, Wagman, Alan, Kemble, George, Leucci, Eleonora, Fendt, Sarah-Maria, Marine, Jean-Christophe, Swinnen, Johannes V

“…One of the key limitations of targeted cancer therapies is the rapid onset of therapy resistance. Taking BRAF-mutant melanoma as paradigm, we previously…”
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Road to Metastasis: The TWEAK Pathway as a Discriminant between Metastasizing and Non-Metastasizing Thick Melanomas by Güvenç, Canan, Antoranz, Asier, Szumera-Ciećkiewicz, Anna, Teterycz, Pawel P., Rutkowski, Piotr R., Rawson, Robert V., Scolyer, Richard A., Thompson, John F., Newton-Bishop, Julia, Stas, Marguerite, Boecxstaens, Veerle, Bechter, Oliver, Vercauteren, Jurgen, Garmyn, Marjan, van den Oord, Joost, Bosisio, Francesca Maria

“…Cutaneous melanoma (CM) is the most aggressive form of skin cancer, and its worldwide incidence is rapidly increasing. Early stages can be successfully treated…”
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Can Multispectral Dermoscopy Help In Distinguishing Blue Color? by Janssen, Laudine, Van Kelst, Sofie, Diricx, Bart, Kimpe, Tom, Papeleu, Jorien, Verhaeghe, Evelien, Brochez, Lieve, Garmyn, Marjan

“…The interpretation of colors is essential in the dermoscopic evaluation of skin lesions. The same blue color on white dermoscopy may indicate blood or pigment…”
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Solar Lentigines are Associated with Better Outcome in Cutaneous Melanoma by Marasigan, Vivien, Güvenç, Canan, Oord, Joost J, Stas, Marguerite, Boecxstaens, Veerle, Bechter, Oliver, Wolter, Pascal, Lambrechts, Diether, Garmyn, Marjan

“…The rising incidence of cutaneous melanoma and its stable high mortality rates despite innovative cancer care, require better prediction of the clinical…”
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1,25-dihydroxyvitamin D3 inhibits ultraviolet B-induced apoptosis, Jun kinase activation, and interleukin-6 production in primary human keratinocytes by De Haes, Petra, Garmyn, Marjan, Degreef, Hugo, Vantieghem, Katleen, Bouillon, Roger, Segaert, Siegfried

“…We investigated the capacity of 1,25‐dihydroxyvitamin D3 [1,25(OH)2D3] to protect human keratinocytes against the hazardous effects of ultraviolet B…”
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A digital mRNA expression signature to classify challenging Spitzoid melanocytic neoplasms by Hillen, Lisa M., Geybels, Milan S., Spassova, Ivelina, Becker, Jürgen C., Gambichler, Thilo, Garmyn, Marjan, Hausen, Axel, Oord, Joost, Winnepenninckx, Véronique

“…Spitzoid neoplasms are a challenging group of cutaneous melanocytic proliferations. They are characterized by epithelioid and/or spindle‐shaped melanocytes and…”
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AKT Delays the Early-Activated Apoptotic Pathway in UVB-Irradiated Keratinocytes Via BAD Translocation by Claerhout, Sofie, Decraene, David, Van Laethem, An, Van Kelst, Sofie, Agostinis, Patrizia, Garmyn, Marjan

“…Upon irradiation with a high dose of UVB, keratinocytes undergo apoptosis as a protective mechanism. In previous work, we demonstrated the existence of an…”
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Insulin-like Growth Factor-1-mediated AKT Activation Postpones the Onset of Ultraviolet B-induced Apoptosis, Providing More Time for Cyclobutane Thymine Dimer Removal in Primary Human Keratinocytes by Decraene, David, Agostinis, Patrizia, Bouillon, Roger, Degreef, Hugo, Garmyn, Marjan

“…Insulin-like growth factor-1 (IGF-1) acts as a potent survival factor in numerous cell lines, primarily through activation of the AKT signaling pathway…”
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A Synthetic Superoxide Dismutase/Catalase Mimetic (EUK-134) Inhibits Membrane-Damage-Induced Activation of Mitogen-Activated Protein Kinase Pathways and Reduces p53 Accumulation in Ultraviolet B-Exposed Primary Human Keratinocytes by Decraene, David, Smaers, Katrien, Gan, David, Mammone, Tom, Matsui, Mary, Maes, Daniel, Declercq, Lieve, Garmyn, Marjan

“…Salen-manganese complexes exhibit powerful superoxide dismutase and catalase activity, with pharmacologic efficacy in several oxidative-stress-associated…”
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New Strategies of Photoprotection by Verschooten, Lien, Claerhout, Sofie, Van Laethem, An, Agostinis, Patricia, Garmyn, Marjan

“…ABSTRACT Adequate photoprotection is essential to control UV‐related disorders, including sunburn, photoaging and photocarcinogenisis. Sun avoidance,…”
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A narrative review on the outcome of primary cutaneous melanomas arising in solid organ transplant recipients by Arne, Vrysen, Canan, Güvenç, Marjan, Garmyn

“…Background Chronic immunosuppression is a risk factor for cutaneous melanoma, as indicated by the increased incidence among solid organ transplant recipients…”
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