Search Results - "Garland, Kyle M"

Pharmacological Activation of cGAS for Cancer Immunotherapy by Garland, Kyle M, Rosch, Jonah C, Carson, Carcia S, Wang-Bishop, Lihong, Hanna, Ann, Sevimli, Sema, Van Kaer, Casey, Balko, Justin M, Ascano, Manuel, Wilson, John T

“…When compartmentally mislocalized within cells, nucleic acids can be exceptionally immunostimulatory and can even trigger the immune-mediated elimination of…”
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Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy by Garland, Kyle M, Sheehy, Taylor L, Wilson, John T

“…The stimulator of interferon genes (STING) cellular signaling pathway is a promising target for cancer immunotherapy. Activation of the intracellular STING…”
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A nanovaccine for enhancing cellular immunity via cytosolic co-delivery of antigen and polyIC RNA by Carson, Carcia S., Becker, Kyle W., Garland, Kyle M., Pagendarm, Hayden M., Stone, Payton T., Arora, Karan, Wang-Bishop, Lihong, Baljon, Jessalyn J., Cruz, Lorena D., Joyce, Sebastian, Wilson, John T.

“…Traditional approaches to cancer vaccines elicit weak CD8+ T cell responses and have largely failed to meet clinical expectations. This is in part due to…”
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Nanoparticle Retinoic Acid-Inducible Gene I Agonist for Cancer Immunotherapy by Wang-Bishop, Lihong, Wehbe, Mohamed, Pastora, Lucinda E., Yang, Jinming, Kimmel, Blaise R., Garland, Kyle M., Becker, Kyle W., Carson, Carcia S., Roth, Eric W., Gibson-Corley, Katherine N., Ulkoski, David, Krishnamurthy, Venkata, Fedorova, Olga, Richmond, Ann, Pyle, Anna Marie, Wilson, John T.

“…Pharmacological activation of the retinoic acid-inducible gene I (RIG-I) pathway holds promise for increasing tumor immunogenicity and improving the response…”
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STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy by Wang-Bishop, Lihong, Kimmel, Blaise R, Ngwa, Verra M, Madden, Matthew Z, Baljon, Jessalyn J, Florian, David C, Hanna, Ann, Pastora, Lucinda E, Sheehy, Taylor L, Kwiatkowski, Alexander J, Wehbe, Mohamed, Wen, Xiaona, Becker, Kyle W, Garland, Kyle M, Schulman, Jacob A, Shae, Daniel, Edwards, Deanna, Wolf, Melissa M, Delapp, Rossane, Christov, Plamen P, Beckermann, Kathryn E, Balko, Justin M, Rathmell, W Kimryn, Rathmell, Jeffrey C, Chen, Jin, Wilson, John T

“…The tumor-associated vasculature imposes major structural and biochemical barriers to the infiltration of effector T cells and effective tumor control…”
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Microparticle Depots for Controlled and Sustained Release of Endosomolytic Nanoparticles by Garland, Kyle M., Sevimli, Sema, Kilchrist, Kameron V., Duvall, Craig L., Cook, Rebecca S., Wilson, John T.

“…Introduction Nucleic acids have gained recognition as promising immunomodulatory therapeutics. However, their potential is limited by several drug delivery…”
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Nanoparticle Delivery of Immunostimulatory Alu RNA for Cancer Immunotherapy by Garland, Kyle M, Kwiatkowski, Alexander J, Tossberg, John T, Crooke, 3rd, Philip S, Aune, Thomas M, Wilson, John T

“…It was recently found that patients with relapsing remitting multiple sclerosis exhibit widespread loss of adenosine-to-inosine (A-to-I) RNA editing, which…”
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