Search Results - "Garinis, George"

DNA damage and innate immunity: links and trade-offs by Chatzinikolaou, Georgia, Karakasilioti, Ismene, Garinis, George A

“…Highlights • Immune DNA sensors signal the presence of damaged or foreign DNA. • DNA damage sensors and the DDR are coupled to innate immune activation. •…”
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The epitranscriptome: reshaping the DNA damage response by Kalamara, Vivian, Garinis, George A.

“…DNA damage poses a threat to cellular viability and fitness. RNA forms an integral part of the DNA damage response (DDR), contributing to the detection and…”
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Looping forward: exploring R-loop processing and therapeutic potential by Stratigi, Kalliopi, Siametis, Athanasios, Garinis, George A

“…Recently, there has been increasing interest in the complex relationship between transcription and genome stability, with specific attention directed toward…”
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Nucleotide excision repair: new tricks with old bricks by Kamileri, Irene, Karakasilioti, Ismene, Garinis, George A

“…Nucleotide excision repair (NER) is a major DNA repair pathway that ensures that the genome remains functionally intact and is faithfully transmitted to…”
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Broken strands, broken minds: Exploring the nexus of DNA damage and neurodegeneration by Stavgiannoudaki, Ioanna, Goulielmaki, Evi, Garinis, George A.

“…Neurodegenerative disorders are primarily characterized by neuron loss progressively leading to cognitive decline and the manifestation of incurable and…”
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DNA Damage and the Aging Epigenome by Siametis, Athanasios, Niotis, George, Garinis, George A.

“…In mammals, genome instability and aging are intimately linked as illustrated by the growing list of patients with progeroid and animal models with inborn DNA…”
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Molecular pathology of rare progeroid diseases by Rieckher, Matthias, Garinis, George A., Schumacher, Björn

“…Progeroid syndromes (PSs) are characterized by the premature onset of age-related pathologies. The genetic mutations underlying PSs are functionally linked to…”
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DNA Damage Response and Metabolic Reprogramming in Health and Disease by Chatzidoukaki, Ourania, Goulielmaki, Evi, Schumacher, Björn, Garinis, George A.

“…Nuclear DNA damage contributes to cellular malfunction and the premature onset of age-related diseases, including cancer. Until recently, the canonical DNA…”
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The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities by Bujarrabal-Dueso, Arturo, Sendtner, Georg, Meyer, David H., Chatzinikolaou, Georgia, Stratigi, Kalliopi, Garinis, George A., Schumacher, Björn

“…The DNA-repair capacity in somatic cells is limited compared with that in germ cells. It has remained unknown whether not only lesion-type-specific, but…”
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Nucleotide Excision Repair and Transcription‐Associated Genome Instability by Apostolou, Zivkos, Chatzinikolaou, Georgia, Stratigi, Kalliopi, Garinis, George A.

“…Transcription is a potential threat to genome integrity, and transcription‐associated DNA damage must be repaired for proper messenger RNA (mRNA) synthesis and…”
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Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity by Alissafi, Themis, Kalafati, Lydia, Lazari, Maria, Filia, Anastasia, Kloukina, Ismini, Manifava, Maria, Lim, Jong-Hyung, Alexaki, Vasileia Ismini, Ktistakis, Nicholas T., Doskas, Triantafyllos, Garinis, George A., Chavakis, Triantafyllos, Boumpas, Dimitrios T., Verginis, Panayotis

“…Regulatory T cells (Tregs) are vital for the maintenance of immune homeostasis, while their dysfunction constitutes a cardinal feature of autoimmunity. Under…”
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DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria by Karakasilioti, Ismene, Kamileri, Irene, Chatzinikolaou, Georgia, Kosteas, Theodoros, Vergadi, Eleni, Robinson, Andria Rasile, Tsamardinos, Iannis, Rozgaja, Tania A., Siakouli, Sandra, Tsatsanis, Christos, Niedernhofer, Laura J., Garinis, George A.

“…Lipodystrophies represent a group of heterogeneous disorders characterized by loss of fat tissue. However, the underlying mechanisms remain poorly understood…”
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SpotitPy: a semi-automated tool for object-based co-localization of fluorescent labels in microscopy images by Akalestou-Clocher, Alexia, Kalamara, Vivian, Topalis, Pantelis, Garinis, George A

“…Abstract Background In fluorescence microscopy, co-localization refers to the spatial overlap between different fluorescent labels in cells. The degree of…”
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Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage by Goulielmaki, Evi, Ioannidou, Anna, Tsekrekou, Maria, Stratigi, Kalliopi, Poutakidou, Ioanna K., Gkirtzimanaki, Katerina, Aivaliotis, Michalis, Evangelou, Konstantinos, Topalis, Pantelis, Altmüller, Janine, Gorgoulis, Vassilis G., Chatzinikolaou, Georgia, Garinis, George A.

“…DNA damage and metabolic disorders are intimately linked with premature disease onset but the underlying mechanisms remain poorly understood. Here, we show…”
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DNA damage-induced inflammation and nuclear architecture by Stratigi, Kalliopi, Chatzidoukaki, Ourania, Garinis, George A.

“…•DNA repair and immune strategies are coordinated in a contextual manner.•Sensors trigger immune signals in response to DNA damage and cytosolic DNA…”
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Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescence by Siametis, Athanasios, Stratigi, Kalliopi, Giamaki, Despoina, Chatzinikolaou, Georgia, Akalestou-Clocher, Alexia, Goulielmaki, Evi, Luke, Brian, Schumacher, Björn, Garinis, George A.

“…Transcription stress has been linked to DNA damage -driven aging, yet the underlying mechanism remains unclear. Here, we demonstrate that Tcea1 −/− cells,…”
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The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing by Goulielmaki, Evi, Tsekrekou, Maria, Batsiotos, Nikos, Ascensão Ferreira, Mariana, Ledaki, Eleftheria, Stratigi, Kalliopi, Chatzinikolaou, Georgia, Topalis, Pantelis, Kosteas, Theodore, Altmüller, Janine, Demmers, Jeroen A., BARBOSA MORAIS, NUNO LUÍS, Garinis, George A.

“…© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,…”
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A mouse model of accelerated liver aging caused by a defect in DNA repair by Gregg, Siobhán Q., Gutiérrez, Verónica, Rasile Robinson, Andria, Woodell, Tyler, Nakao, Atsunori, Ross, Mark A., Michalopoulos, George K., Rigatti, Lora, Rothermel, Carrie E., Kamileri, Irene, Garinis, George A., Beer Stolz, Donna, Niedernhofer, Laura J.

“…The liver changes with age, leading to an impaired ability to respond to hepatic insults and increased incidence of liver disease in the elderly. Therefore,…”
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Microglia-derived extracellular vesicles trigger age-related neurodegeneration upon DNA damage by Arvanitaki, Ermioni S, Goulielmaki, Evi, Gkirtzimanaki, Katerina, Niotis, George, Tsakani, Edisona, Nenedaki, Electra, Rouska, Iliana, Kefalogianni, Mary, Xydias, Dionysios, Kalafatakis, Ilias, Psilodimitrakopoulos, Sotiris, Karagogeos, Domna, Schumacher, Björn, Stratakis, Emmanuel, Garinis, George A

“…DNA damage and neurodegenerative disorders are intimately linked but the underlying mechanism remains elusive. Here, we show that persistent DNA lesions in…”
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DNA Damage: From Chronic Inflammation to Age-Related Deterioration by Ioannidou, Anna, Goulielmaki, Evi, Garinis, George A

“…To lessen the "wear and tear" of existence, cells have evolved mechanisms that continuously sense DNA lesions, repair DNA damage and restore the compromised…”
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