Search Results - "Garigipati, Ravi"

Identification of a novel, non-tetrahydroquinoline variant of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, with improved aqueous solubility by Kalgutkar, Amit S., Frederick, Kosea S., Hatch, Heather L., Ambler, Catherine M., Perry, David A., Garigipati, Ravi S., Chang, George C., Lefker, Bruce A., Clark, Ronald W., Morehouse, Lee A., Francone, Omar, Hu, Xiao

“…Abstract 1. Elaborate studies of cholesteryl ester transfer protein (CETP) polymorphisms and genetic deficiency in humans suggest direct links between CETP,…”
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Novel solid-phase preparation of 2,6,9-trisubstituted purines for combinatorial library generation by Dorff, Peter H, Garigipati, Ravi S

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An NMR Method To Identify Nondestructively Chemical Compounds Bound to a Single Solid-Phase-Synthesis Bead for Combinatorial Chemistry Applications by Sarkar, Susanta K, Garigipati, Ravi S, Adams, Jerry L, Keifer, Paul A

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Characterization of novel composites from polybenzoxazine and granite powder by Garigipati, Ravi Krishna Swami, Malkapuram, Ramakrishna

“…The potential of using granite dust as reinforcement into polybenzoxazine matrix was investigated. In this article, novel granite powder waste-reinforced…”
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Use of Spin Echo Magic Angle Spinning (1)H NMR in Reaction Monitoring in Combinatorial Organic Synthesis by Garigipati, Ravi S., Adams, Bruce, Adams, Jerry L., Sarkar, Susanta K.

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1-Substituted 4-Aryl-5-pyridinylimidazoles:  A New Class of Cytokine Suppressive Drugs with Low 5-Lipoxygenase and Cyclooxygenase Inhibitory Potency by Boehm, Jeffrey C, Smietana, Juanita M, Sorenson, Margaret E, Garigipati, Ravi S, Gallagher, Timothy F, Sheldrake, Peter L, Bradbeer, Jeremy, Badger, Alison M, Laydon, Jeffrey T, Lee, John C, Hillegass, Leonard M, Griswold, Donald E, Breton, John J, Chabot-Fletcher, Marie C, Adams, Jerry L

“…A series of 1-alkyl- or -aryl-4-aryl-5-pyridinylimidazoles (A) were prepared and tested for their ability to bind to a recently discovered protein kinase…”
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Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase by Gallagher, Timothy F., Seibel, George L., Kassis, Shouki, Laydon, Jeffrey T., Blumenthal, Mary Jane, Lee, John C., Lee, Dennis, Boehm, Jeffrey C., Fier-Thompson, Susan M., Abt, Jeffrey W., Soreson, Margaret E., Smietana, Juanita M., Hall, Ralph F., Garigipati, Ravi S., Bender, Paul E., Erhard, Karl F., Krog, Arnold J., Hofmann, Glenn A., Sheldrake, Peter L., McDonnell, Peter C., Kumar, Sanjay, Young, Peter R., Adams, Jerry L.

“…Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38) kinase which is a member of a stress-induced signal transduction…”
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Enantioselective Synthesis of 5-LO Inhibitor Hydroxyureas. Tandem Nucleophilic Addition−Intramolecular Cyclization of Chiral Nitrones by Lantos, Ivan, Flisak, Joseph, Liu, Li, Matsuoka, Richard, Mendelson, Wilf, Stevenson, David, Tubman, Ken, Tucker, Lynn, Zhang, Wei-Yuan, Adams, Jerry, Sorenson, Margaret, Garigipati, Ravi, Erhardt, Karl, Ross, Steve

“…An enantioselective synthesis of chiral hydroxyurea based 5-lipoxygenase inhibitors is reported via a five-step sequence in about 30% overall yield. The…”
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Use of Spin Echo Magic Angle Spinning 1H NMR in Reaction Monitoring in Combinatorial Organic Synthesis by Garigipati, Ravi S, Adams, Bruce, Adams, Jerry L, Sarkar, Susanta K

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Process Development and Scale-Up of an Hsp90 Inhibitor by Duan, Shengquan, Venkatraman, Sripathy, Hong, Xuechuan, Huang, Kenneth, Ulysse, Luckner, Mobele, Bingidimi I, Smith, Alexander, Lawless, Lawrence, Locke, Andrew, Garigipati, Ravi

“…A scalable process for the manufacture of a Hsp90 inhibitor was developed and optimized. Key features in the seven-step process include a selective SNAr…”
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Stereoselective total syntheses of the antitumor antibiotics (+)-actinobolin and (-)-bactobolin from a common bridged lactone intermediate by Garigipati, Ravi S, Tschaen, David M, Weinreb, Steven M

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Stereospecific synthesis of acyclic unsaturated amino alcohols. A new approach to threo and erythro sphingosine by Garigipati, Ravi S, Weinreb, Steven M

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Stereoselective total synthesis of the antitumor antibiotic (-)-bactobolin by Garigipati, Ravi S, Weinreb, Steven M

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Total synthesis of (+)-actinobolin by Garigipati, Ravi S, Tschaen, David M, Weinreb, Steven M

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Development of a strategy for convergent total synthesis of the aureolic acid antitumor antibiotics by Dodd, John H, Garigipati, Ravi S, Weinreb, Steven M

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Attempted synthesis of biotin by Turos, Edward, Parvez, M, Garigipati, Ravi S, Weinreb, Steven M

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Total synthesis of anhydrocannabisativene by Bailey, Thomas R, Garigipati, Ravi S, Morton, Judith A, Weinreb, Steven M

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Reagents for combinatorial organic synthesis: preparation and uses of Rink-chloride by Garigipati, Ravi S.

“…The preparation of Rink-chloride and its utility in attaching various nucleophiles to a solid support are described…”
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Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity by Adams, Jerry L., Boehm, Jeffrey C., Gallagher, Timothy F., Kassis, Shouki, Webb, Edward F., Hall, Ralph, Sorenson, Margaret, Garigipati, Ravi, Griswold, Don E., Lee, John C.

“…Optimization of a series of N-1-cycloalkyl-4-aryl-5-(pyrimidin-4-yl)imidazole inhibitors of p38 kinase is reported. Oral administration of inhibitors…”
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Diastereoselective synthesis of unsaturated vicinal amino alcohols via Diels-Alder reactions of N-sulfinyl dienophiles by Garigipati, Ravi S, Freyer, Alan J, Whittle, Robert R, Weinreb, Steven M

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