Search Results - "Garidel, P."

Systematic investigation of the effect of lyophilizate collapse on pharmaceutically relevant proteins I: stability after freeze-drying by Schersch, K, Betz, O, Garidel, P, Muehlau, S, Bassarab, S, Winter, G

“…The objective of this work was to investigate the effect of cake collapse during freeze-drying on the stability of protein lyophilizates containing a…”
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Systematic investigation of the effect of lyophilizate collapse on pharmaceutically relevant proteins III: Collapse during storage at elevated temperatures by Schersch, K., Betz, O., Garidel, P., Muehlau, S., Bassarab, S., Winter, G.

“…This study investigates the effect of lyophilizate collapse on the stability of pharmaceutical proteins. Recently, it was shown that collapse during…”
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The application of STEP-technology® for particle and protein dispersion detection studies in biopharmaceutical research by Gross-Rother, J., Herrmann, N., Blech, M., Pinnapireddy, S.R., Garidel, P., Bakowsky, U.

“…[Display omitted] Particle detection and analysis techniques are essential in biopharmaceutical industries to evaluate the quality of various parenteral…”
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Stabilization of IgG1 in spray-dried powders for inhalation by Schüle, S., Schulz-Fademrecht, T., Garidel, P., Bechtold-Peters, K., Frieß, W.

“…The protein stabilizing capabilities of spray-dried IgG1/mannitol formulations were evaluated. The storage stability was tested at different residual moisture…”
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Thermodynamic Characterization of Bile Salt Aggregation as a Function of Temperature and Ionic Strength Using Isothermal Titration Calorimetry by Garidel, P, Hildebrand, A, Neubert, R, Blume, A

“…The critical micellar concentration (cmc) and the demicellization enthalpy ΔH demic of the primary aggregates of sodium cholate (NaC) and sodium deoxycholate…”
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Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells by Gutsmann, T, Howe, J, Zähringer, U, Garidel, P, Schromm, A B, Koch, M H J, Fujimoto, Y, Fukase, K, Moriyon, I, Martínez-de-Tejada, G, Brandenburg, K

“…The structural prerequisites for lipopolysaccharide (LPS) and its partial structures for the activation of the Limulus clotting cascade (Limulus amebocyte…”
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Composition dependence of vesicle morphology and mixing properties in a bacterial model membrane system by Pozo Navas, B., Lohner, K., Deutsch, G., Sevcsik, E., Riske, K.A., Dimova, R., Garidel, P., Pabst, G.

“…We have determined the mixing properties and lamellar organization of bacterial membrane mimetics composed of 1-palmitoyl-2-oleoyl-phosphatidylethanolamine…”
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Thermodynamic properties of association colloids by Garidel, P., Hildebrand, A.

“…The single components of association colloids are amphiphilic molecules, which are held together by van der Waals forces and/or hydrogen interactions. The…”
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Structural Polymorphism and Endotoxic Activity of Synthetic Phospholipid-like Amphiphiles by Brandenburg, K, Hawkins, L, Garidel, P, Andrä, J, Müller, M, Heine, H, Koch, M. H. J, Seydel, U

“…The physicochemical characteristics and in vitro biological activity of various synthetic hexaacyl phospholipid dimers were compared with the respective…”
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Nonideal mixing and phase separation in phosphatidylcholine-phosphatidic acid mixtures as a function of acyl chain length and pH by Garidel, P., Johann, C., Blume, A.

“…The miscibilities of phosphatidic acids (PAs) and phosphatidylcholines (PCs) with different chain lengths (n = 14, 16) at pH 4, pH 7, and pH 12 were examined…”
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The calculation of heat capacity curves and phase diagrams based on regular solution theory by Garidel, P., Johann, C., Blume, A.

“…The intermolecular interactions of molecules within the bilayer are responsible for the lipid organisation, e.g. domain formation, and the interaction and…”
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Phase diagrams of monoacylated amide-linked disaccharide glycolipids by Gerber, S., Wulf, M., Milkereit, G., Vill, V., Howe, J., Roessle, M., Garidel, P., Gutsmann, T., Brandenburg, K.

“…A series of monoacylated glycolipids with even-numbered acyl chain lengths ranging from saturated C11 to C15 and an unsaturated C17:1 fatty acid connected by…”
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What can calorimetry tell us about changes of three-dimensional aggregate structures of phospholipids and glycolipids? by Brandenburg, K., Garidel, P., Howe, J., Andrä, J., Hawkins, L., Koch, M.H.J., Seydel, U.

“…It is reported on the structural polymorphism of the main amphiphilic cell membrane compounds, phospholipids and glycolipids, with special regard to…”
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Investigation into the interaction of the phosphoporin PhoE with outer membrane lipids: physicochemical characterization and biological activity by Andrä, Jörg, de Cock, Hans, Garidel, Patrick, Howe, Jörg, Brandenburg, Klaus

“…Outer membrane pore proteins such as phosphoporin (PhoE) are important constituents of Gram-negative bacteria such as Escherichia coli. We have studied the…”
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New approaches to the simulation of heat-capacity curves and phase diagrams of pseudobinary phospholipid mixtures by Johann, C., Garidel, P., Mennicke, L., Blume, A.

“…A simulation program using least-squares minimization was developed to calculate and fit heat capacity (cp) curves to experimental thermograms of dilute…”
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Prediction and Reduction of the Aggregation of Monoclonal Antibodies by van der Kant, Rob, Karow-Zwick, Anne R., Van Durme, Joost, Blech, Michaela, Gallardo, Rodrigo, Seeliger, Daniel, Aßfalg, Kerstin, Baatsen, Pieter, Compernolle, Griet, Gils, Ann, Studts, Joey M., Schulz, Patrick, Garidel, Patrick, Schymkowitz, Joost, Rousseau, Frederic

“…Protein aggregation remains a major area of focus in the production of monoclonal antibodies. Improving the intrinsic properties of antibodies can improve…”
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Thermodynamics of Lipid Organization and Domain Formation in Phospholipid Bilayers by Garidel, Patrick, Johann, Christof, Blume, Alfred

“…Abstract Lipid organization and domain formation in phospholipid membranes has a large impact on a number of physical membrane properties such as membrane…”
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1,2-Dimyristoyl- sn-glycero-3-phosphoglycerol (DMPG) monolayers: influence of temperature, pH, ionic strength and binding of alkaline earth cations by Garidel, Patrick, Blume, Alfred

“…Ion binding and lipid ionization of the acidic phospholipid 1,2-dimyristoyl- sn-glycero-3-phosphoglycerol (DMPG) in monolayers was studied by measuring the…”
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Thermodynamics of Demicellization of Mixed Micelles Composed of Sodium Oleate and Bile Salts by Hildebrand, Annegret, Garidel, Patrick, Neubert, Reinhard, Blume, Alfred

“…Isothermal titration calorimetry (ITC) was used to determine the critical micelle concentration (cmc) and the thermodynamic parameters associated with the…”
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Bile Salt Induced Solubilization of Synthetic Phosphatidylcholine Vesicles Studied by Isothermal Titration Calorimetry by Hildebrand, Annegret, Neubert, Reinhard, Garidel, Patrick, Blume, Alfred

“…Isothermal titration calorimetry (ITC) was used to investigate the interactions of bile salts with phosphatidylcholine vesicles. We determined the partition…”
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