Investigation of Cochlospermum religiosum leaves for antidepressant and anxiolytic activities and its synergistic effect with imipramine and fluoxetine

The present study was conducted to evaluate the effect of Cochlospermum religiosum (CSR) in animal models of depression and anxiety. The CSR leaves are well known for their sedative, antibacterial, antifungal antioxidant, memory enhancing, anxiolytic and antidepressant potential. In present study, t...

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Published in:	Environmental science and pollution research international Vol. 29; no. 18; pp. 27172 - 27181
Main Authors:	Bhatt, Shvetank, Behl, Tapan, Sehgal, Aayush, Singh, Sukhbir, Sharma, Neelam, Chigurupati, Sridevi, Ahmed, Amira Saber, Gari, Sreelakshmi Bada V.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-04-2022 Springer Nature B.V
Subjects:	Animal models Animals Anti-Anxiety Agents - pharmacology Anti-Anxiety Agents - therapeutic use Antidepressants Antidepressive Agents - pharmacology Antiinfectives and antibacterials Antioxidants Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Behavior, Animal Bixaceae Burying behavior Cochlospermum religiosum Depression - drug therapy Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Fluoxetine Fluoxetine - pharmacology Fungicides Hypothermia Imipramine Imipramine - pharmacology In vivo methods and tests Leaves Locomotor activity Mental depression Mice Motor Activity Plant extracts Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats Research Article Reserpine Reserpine - pharmacology Synergistic effect Waste Water Technology Water Management Water Pollution Control Antidepressant Depression Anxiolytic Synergism Reserpine Cochlospermum religiosum
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Summary:	The present study was conducted to evaluate the effect of Cochlospermum religiosum (CSR) in animal models of depression and anxiety. The CSR leaves are well known for their sedative, antibacterial, antifungal antioxidant, memory enhancing, anxiolytic and antidepressant potential. In present study, the extract of the leaves is used to relieve the anxiolytic and antidepressant potential. The leaves of CSR were investigated for antidepressant and anxiolytic activities in mice behavioural models namely, spontaneous locomotor activity (SLA), forced swim test (FST), tail suspension test (TST), elevated plus maze (EPM) and marble burying behaviour (MBB). The mechanism was supported by reserpine-induced hypothermia (RIH). Further, the in vivo synergistic evaluation of the CSR leaf extract was evaluated with imipramine and fluoxetine. The treatment of mice with ethanolic extract of CSR leaves for 7 days resulted significant antidepressant and anxiolytic effects ( p < 0.05 for 50 mg/Kg p.o / p < 0.01 for 100 mg/kg p.o) with null impact on baseline locomotor activity. Further, the study on rat RIH model revealed that the CSR (50 mg/kg p.o) predominantly antagonized the effect ( p < 0.05) of reserpine. Furthermore, synergic action was screened by co-administration of leaf extracts of CSR with fluoxetine (10 mg/Kg, i.p.) and imipramine (10 mg/Kg, i.p.) at below therapeutic dose levels using FST, TST, EPM and MBB. The synergistic effect was significant ( p < 0.05) for both antidepressant and anxiolytic activities as compared to therapeutic doses of extract, imipramine and fluoxetine.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0944-1344 1614-7499
DOI:	10.1007/s11356-021-18359-5