The Effects of Vitamin D Supplementation on C-Reactive Protein and Systolic and Diastolic Blood Pressure in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials

An inverse relationship between vitamin D supplementation and C-reactive protein (CRP) and hypertension has been reported, mostly through observational data. This inverse relationship, however, has not been confirmed in randomized controlled trials (RCTs). A meta-analysis of RCTs is needed to provid...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of the Academy of Nutrition and Dietetics Vol. 124; no. 3; pp. 387 - 396.e5
Main Authors:	Jiang, Qidong, Prabahar, Kousalya, Saleh, Saleh A.K., Adly, Heba M., Velu, Periyannan, Adi, Abdul Rahman, Baradwan, Saeed, Hajkhalaf, Miar Ibrahim, Baredwan, Ahlam, Gari, Faris, Kord-Varkaneh, Hamed
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-03-2024
Subjects:	Blood Pressure C-Reactive Protein CRP Dietary Supplements Female Humans Inflammation Meta-analysis Postmenopausal women Postmenopause Randomized Controlled Trials as Topic Vitamin D CRP Blood pressure Postmenopausal women Inflammation Vitamin D Meta-analysis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	An inverse relationship between vitamin D supplementation and C-reactive protein (CRP) and hypertension has been reported, mostly through observational data. This inverse relationship, however, has not been confirmed in randomized controlled trials (RCTs). A meta-analysis of RCTs is needed to provide more robust evidence. This systematic review of RCTs was conducted to assess the effect of vitamin D supplementation on CRP, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in postmenopausal women. Four databases (PubMed, Web of Science, Embase, and Scopus) were systemically searched to identify relevant RCTs published in international scientific journals up to January 2023. Changes from baseline and SDs of CRP, SBP, and DBP were compared between postmenopausal women who received vitamin D supplementation and those who did not (controls). These parameters were applied to compute the overall effect sizes using the random-effects model. Data were summarized as mean difference (MD) with 95% CI. Heterogeneity among arms was scrutinized using the Cochrane’s Q test and I2 statistic. Publication bias was judged by means of funnel plots and Egger's test. Seven studies with 6 arms on CRP, 6 arms on SBP, and 6 arms on DBP were included in the meta-analysis. Combined effect sizes suggested a significant effect of vitamin D supplementation on CRP (MD = –0.65 mg/L; 95% CI –0.93 to –0.37 mg/L; P < .001). In addition, CRP concentrations were signiﬁcantly reduced after vitamin D supplementation in studies with a duration of more than 3 months (MD = –0.91 mg/L; 95% CI –1.37 to –0.45 mg/L; P < .001) and studies involving doses of ≤1,000 IU/d (MD = –2.10 mg/L; 95% CI –2.51 to –1.68 mg/L; P < .001). Vitamin D supplementation did not reduce SBP signiﬁcantly (MD = –1.06 mm Hg; 95% CI –2.43 to 0.30 mm Hg; P = .127) and DBP (MD = 0.003 mm Hg; 95% CI –0.86 to 0.86 mm Hg; P = .994) levels compared with control groups. This meta-analysis concluded that vitamin D supplementation is associated with reduced CRP concentrations among postmenopausal women.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	2212-2672 2212-2680
DOI:	10.1016/j.jand.2023.10.013