Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia

Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia

AIM:To assess the possible association between PTPN22(R620W) gene polymorphism and inflammatory bowel disease(IBD).METHODS:One hundred and sixty-four patients with IBD 105 Crohn's disease(CD) and 59 ulcerative colitis(UC) and 100 healthy controls were recruited.Genotyping of the PTPN22 gene 185...

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Published in:World journal of gastroenterology : WJG Vol. 16; no. 4; pp. 479 - 483
Main Authors: Sfar, Imen, Ben Aleya, Walid, Mouelhi, Leila, Aouadi, Houda, Ben Rhomdhane, Thouraya, Makhlouf, Mouna, Ayed-Jendoubi, Salwa, Gargaoui, Houda, Najjar, Taoufik, Ben Abdallah, Taieb, Ayed, Khaled, Gorgi, Yousr
Format: Journal Article
Language:English
Published: United States Laboratory of Immunology, Charles Nicolle Hospital, Tunis 1006, Tunisia%Department of Gastroenterology, Charles Nicolle Hospital, Tunis 1006, Tunisia 28-01-2010
The WJG Press and Baishideng
Subjects:
Adult
Brief
Case-Control Studies
Colitis, Ulcerative - genetics
Crohn Disease - genetics
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics
Tunisia
Young Adult
Tunisia
Inflammatory bowel disease
PTPN22
Genetic susceptibility
Genetic polymorphism
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Summary:AIM:To assess the possible association between PTPN22(R620W) gene polymorphism and inflammatory bowel disease(IBD).METHODS:One hundred and sixty-four patients with IBD 105 Crohn's disease(CD) and 59 ulcerative colitis(UC) and 100 healthy controls were recruited.Genotyping of the PTPN22 gene 1858C→T polymorphism was performed by restriction fragment length polymorphism-polymerase chain reaction with Rsa Ⅰ digestion.RESULTS:The genotypic and allelic frequencies of(R620W) PTPN22 gene polymorphism reveal a sign...
Bibliography:Inflammatory bowel disease
Inflammatory bowel disease; PTPN22; Genetic polymorphism; Genetic susceptibility
Genetic susceptibility
14-1219/R
R574
Genetic polymorphism
PTPN22
ObjectType-Article-1
SourceType-Scholarly Journals-1
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Author contributions: Ben Aleya W, Sfar I, Aouadi H, Makhlouf M, Ben Rhomdhane T and Ayed-Jendoubi S performed the majority of the experiments; Mouelhi L and Najjar T collected all the human material; Ben Abdallah T, Ayed K and Gorgi Y designed, supervised and provided financial support for this work; and Ben Aleya W wrote the manuscript.
Correspondence to: Dr. Ben Aleya Walid, Laboratory of Immunology, Charles Nicolle Hospital, Boulevard 9 Avril, Tunis 1006, Tunisia. b_a_w@hotmail.fr
Telephone: +216-98-478866 Fax: +216-71-561156
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v16.i4.479