Search Results - "Gardner, Thomas J"

Kinetic Analysis Reveals the Fate of a MicroRNA following Target Regulation in Mammalian Cells by Baccarini, Alessia, Chauhan, Hemangini, Gardner, Thomas J., Jayaprakash, Anitha D., Sachidanandam, Ravi, Brown, Brian D.

“…Considerable details about microRNA (miRNA) biogenesis and regulation have been uncovered, but little is known about the fate of the miRNA subsequent to target…”
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CD46 facilitates entry and dissemination of human cytomegalovirus by Stein, Kathryn R., Gardner, Thomas J., Hernandez, Rosmel E., Kraus, Thomas A., Duty, James A., Ubarretxena-Belandia, Iban, Moran, Thomas M., Tortorella, Domenico

“…Human cytomegalovirus (CMV) causes a wide array of disease to diverse populations of immune-compromised individuals. Thus, a more comprehensive understanding…”
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Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis by Miller, Matthew S, Gardner, Thomas J, Krammer, Florian, Aguado, Lauren C, Tortorella, Domenico, Basler, Christopher F, Palese, Peter

“…Antigenic diversity shapes immunity in distinct and unexpected ways. This is particularly true of the humoral response generated against influenza A viruses…”
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ISG15 deficiency and increased viral resistance in humans but not mice by Speer, Scott D., Li, Zhi, Buta, Sofija, Payelle-Brogard, Béatrice, Qian, Li, Vigant, Frederic, Rubino, Erminia, Gardner, Thomas J., Wedeking, Tim, Hermann, Mark, Duehr, James, Sanal, Ozden, Tezcan, Ilhan, Mansouri, Nahal, Tabarsi, Payam, Mansouri, Davood, Francois-Newton, Véronique, Daussy, Coralie F., Rodriguez, Marisela R., Lenschow, Deborah J., Freiberg, Alexander N., Tortorella, Domenico, Piehler, Jacob, Lee, Benhur, García-Sastre, Adolfo, Pellegrini, Sandra, Bogunovic, Dusan

“…ISG15 is an interferon (IFN)-α/β-induced ubiquitin-like protein. It exists as a free molecule, intracellularly and extracellularly, and conjugated to target…”
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Development of a high-content screen for the identification of inhibitors directed against the early steps of the cytomegalovirus infectious cycle by Gardner, Thomas J, Cohen, Tobias, Redmann, Veronika, Lau, Zerlina, Felsenfeld, Dan, Tortorella, Domenico

“…Human cytomegalovirus (CMV) is a latent and persistent virus whose proliferation increases morbidity and mortality of immune-compromised individuals. The…”
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Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection by Heaton, Nicholas S., Moshkina, Natasha, Fenouil, Romain, Gardner, Thomas J., Aguirre, Sebastian, Shah, Priya S., Zhao, Nan, Manganaro, Lara, Hultquist, Judd F., Noel, Justine, Sachs, David, Hamilton, Jennifer, Leon, Paul E., Chawdury, Amit, Tripathi, Shashank, Melegari, Camilla, Campisi, Laura, Hai, Rong, Metreveli, Giorgi, Gamarnik, Andrea V., García-Sastre, Adolfo, Greenbaum, Benjamin, Simon, Viviana, Fernandez-Sesma, Ana, Krogan, Nevan J., Mulder, Lubbertus C.F., van Bakel, Harm, Tortorella, Domenico, Taunton, Jack, Palese, Peter, Marazzi, Ivan

“…Viruses are obligate parasites and thus require the machinery of the host cell to replicate. Inhibition of host factors co-opted during active infection is a…”
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Functional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein by Gardner, Thomas J., Stein, Kathryn R., Duty, J. Andrew, Schwarz, Toni M., Noriega, Vanessa M., Kraus, Thomas, Moran, Thomas M., Tortorella, Domenico

“…The prototypic β-herpesvirus human cytomegalovirus (CMV) establishes life-long persistence within its human host. The CMV envelope consists of various protein…”
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Human cytomegalovirus US28 facilitates cell-to-cell viral dissemination by Noriega, Vanessa M, Gardner, Thomas J, Redmann, Veronika, Bongers, Gerold, Lira, Sergio A, Tortorella, Domenico

“…Human cytomegalovirus (HCMV) encodes a number of viral proteins with homology to cellular G protein-coupled receptors (GPCRs). These viral GPCRs, including…”
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The Microtubule Inhibitor Podofilox Inhibits an Early Entry Step of Human Cytomegalovirus by Cohen, Tobias, Schwarz, Toni M, Vigant, Frederic, Gardner, Thomas J, Hernandez, Rosmel E, Lee, Benhur, Tortorella, Domenico

“…Human cytomegalovirus is a ubiquitous β-herpesvirus that infects many different cell types through an initial binding to cell surface receptors followed by a…”
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Virion Glycoprotein-Mediated Immune Evasion by Human Cytomegalovirus: a Sticky Virus Makes a Slick Getaway by Gardner, Thomas J, Tortorella, Domenico

“…The prototypic herpesvirus human cytomegalovirus (CMV) exhibits the extraordinary ability to establish latency and maintain a chronic infection throughout the…”
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Development of a High-Throughput Assay To Measure the Neutralization Capability of Anti-Cytomegalovirus Antibodies by Gardner, Thomas J., Bolovan-Fritts, Cynthia, Teng, Melissa W., Redmann, Veronika, Kraus, Thomas A., Sperling, Rhoda, Moran, Thomas, Britt, William, Weinberger, Leor S., Tortorella, Domenico

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Engineering CAR-T cells to activate small-molecule drugs in situ by Gardner, Thomas J., Lee, J. Peter, Bourne, Christopher M., Wijewarnasuriya, Dinali, Kinarivala, Nihar, Kurtz, Keifer G., Corless, Broderick C., Dacek, Megan M., Chang, Aaron Y., Mo, George, Nguyen, Kha M., Brentjens, Renier J., Tan, Derek S., Scheinberg, David A.

“…Chimeric antigen receptor (CAR)-T cells represent a major breakthrough in cancer therapy, wherein a patient’s own T cells are engineered to recognize a tumor…”
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Potentiating antibody-dependent killing of cancers with CAR T cells secreting CD47-SIRPα checkpoint blocker by Dacek, Megan M., Kurtz, Keifer G., Wallisch, Patrick, Pierre, Stephanie A., Khayat, Shireen, Bourne, Christopher M., Gardner, Thomas J., Vogt, Kristen C., Aquino, Nica, Younes, Anas, Scheinberg, David A.

“…•“Orexi” CAR T cells in combination with an orthogonally targeted monoclonal antibody are more effective than traditional CAR T cells.•OrexiCAR T cells…”
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Development of a p‑Hydroxybenzyl-Alcohol-Linked Glutamate Prodrug for Activation by Pseudomonas Carboxypeptidase G2 by Lee, J. Peter, Corless, Broderick C., Gardner, Thomas J., Scheinberg, David A., Tan, Derek S.

“…Directed enzyme–prodrug therapies used for targeted drug delivery require prodrugs that are chemically stable and processed efficiently by the activating…”
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A TCR mimic CAR T cell specific for NDC80 is broadly reactive with solid tumors and hematologic malignancies by Klatt, Martin G., Dao, Tao, Yang, Zhiyuan, Liu, Jianying, Mun, Sung Soo, Dacek, Megan M., Luo, Hanzhi, Gardner, Thomas J., Bourne, Christopher, Peraro, Leila, Aretz, Zita E.H., Korontsvit, Tanya, Lau, Michael, Kharas, Michael G., Liu, Cheng, Scheinberg, David A.

“…Target identification for chimeric antigen receptor (CAR) T-cell therapies remains challenging due to the limited repertoire of tumor-specific surface…”
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Investigating N-arylpyrimidinamine (NAPA) compounds as early-stage inhibitors against human cytomegalovirus by Parsons, Andrea J., Ophir, Sabrina I., Gardner, Thomas J., Paredes, Jailene Casado, Stein, Kathryn R., Kwasny, Steven M., Cardinale, Steven C., Torhan, Matthew, Prichard, Mark N., James, Scott H., Atanasoff, Kristina E., G-Dayanandan, Narendran, Bowlin, Terry L., Opperman, Timothy J., Tortorella, Domenico

“…Human cytomegalovirus (CMV) is a ubiquitous β-herpesvirus that establishes latent asymptomatic infections in healthy individuals but can cause serious…”
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Human cytomegalovirus gH stability and trafficking are regulated by ER-associated degradation and transmembrane architecture by Gardner, Thomas J., Hernandez, Rosmel E., Noriega, Vanessa M., Tortorella, Domenico

“…The prototypic betaherpesvirus human cytomegalovirus (CMV) establishes life-long persistence within its human host. While benign in healthy individuals, CMV…”
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Targeted Cellular Micropharmacies: Cells Engineered for Localized Drug Delivery by Gardner, Thomas J, Bourne, Christopher M, Dacek, Megan M, Kurtz, Keifer, Malviya, Manish, Peraro, Leila, Silberman, Pedro C, Vogt, Kristen C, Unti, Mildred J, Brentjens, Renier, Scheinberg, David

“…The recent emergence of engineered cellular therapies, such as Chimeric antigen receptor (CAR) CAR T and T cell receptor (TCR) engineered T cells, has shown…”
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Human cytomegalovirus US3 modulates destruction of MHC class I molecules by Noriega, Vanessa M., Hesse, Julia, Gardner, Thomas J., Besold, Katrin, Plachter, Bodo, Tortorella, Domenico

“…► HCMV US3 attenuates degradation of MHC class I molecules induced by US11. ► Enhanced ER retention of class I molecules is evident during stable co-expression…”
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ATPase4A Autoreactivity and Its Association With Autoimmune Phenotypes in the Type 1 Diabetes Genetics Consortium Study by Wenzlau, Janet M, Fain, Pamela R, Gardner, Thomas J, Frisch, Lisa M, Annibale, Bruno, Hutton, John C

“…Autoantibodies targeting the H+/K+-ATPase proton pump of the gastric parietal cell (parietal cell antibodies [PCA]) are diagnostic of atrophic body gastritis…”
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