Search Results - "Gardner, T. W."

Energy sources for glutamate neurotransmission in the retina: absence of the aspartate/glutamate carrier produces reliance on glycolysis in glia by Xu, Y., Ola, M. S., Berkich, D. A., Gardner, T. W., Barber, A. J., Palmieri, F., Hutson, S. M., LaNoue, K. F.

“…The mitochondrial transporter, the aspartate/glutamate carrier (AGC), is a necessary component of the malate/aspartate cycle, which promotes the transfer into…”
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Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin by Barber, A J, Lieth, E, Khin, S A, Antonetti, D A, Buchanan, A G, Gardner, T W

“…This study determined whether retinal degeneration during diabetes includes retinal neural cell apoptosis. Image analysis of retinal sections from…”
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Diabetic retinopathy by AIELLO, L. P, GARDNER, T. W, KING, G. L, BLANKENSHIP, G, CAVALLERANO, J. D, FERRIS, F. L, KLEIN, R

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TELEMAM: A cluster randomised trial to assess the use of telemedicine in multi-disciplinary breast cancer decision making by Kunkler, I.H, Prescott, R.J, Lee, R.J, Brebner, J.A, Cairns, J.A, Fielding, R.G, Bowman, A, Neades, G, Walls, A.D.F, Chetty, U, Dixon, J.M, Smith, M.E, Gardner, T.W, Macnab, M, Swann, S, Maclean, J.R

“…Abstract Aim The TELEMAM trial aimed to assess the clinical effectiveness and costs of telemedicine in conducting breast cancer multi-disciplinary meetings…”
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Spinal epidural abscesses – The role for non-operative management: A systematic review by Gardner, W.T., Rehman, H., Frost, A.

“…Spinal Epidural Abscesses (SEAs) are traditionally seen as a surgical emergency. However, SEAs can be discovered in entirely asymptomatic patients. This…”
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Macropore flow on a reclaimed surface mine: infiltration and hillslope hydrology by Guebert, Michael D, Gardner, Thomas W

“…Surface coal mining in central Pennsylvania alters the physical and hydrological properties of soil from its undisturbed state and changes the surface…”
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Glucose variability and inner retinal sensory neuropathy in persons with type 1 diabetes mellitus by Stem, M S, Dunbar, G E, Jackson, G R, Farsiu, S, Pop-Busui, R, Gardner, T W

“…Purpose To quantify early neuroretinal alterations in patients with type 1 diabetes mellitus (T1DM) and to assess whether glycemic variability contributes to…”
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Central serous chorioretinopathy in women by Quillen, D A, Gass, D M, Brod, R D, Gardner, T W, Blankenship, G W, Gottlieb, J L

“…Central serous chorioretinopathy is a disorder that typically affects young and middle-aged men. Although extensive information is available pertaining to the…”
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Astrocytes increase barrier properties and ZO-1 expression in retinal vascular endothelial cells by Gardner, TW, Lieth, E, Khin, SA, Barber, AJ, Bonsall, DJ, Lesher, T, Rice, K, Brennan, WA, Jr

“…Diabetic retinopathy and other diseases associated with retinal edema are characterized by increased microvascular leakage. Astrocytes have been proposed to…”
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Effect of Vascular Endothelial Growth Factor on Cultured Endothelial Cell Monolayer Transport Properties by Chang, Yong S., Munn, Lance L., Hillsley, Mechteld V., Dull, Randal O., Yuan, Jin, Lakshminarayanan, Sunitha, Gardner, Thomas W., Jain, Rakesh K., Tarbell, John M.

“…Vascular endothelial growth factor (VEGF) is a potent enhancer of microvascular permeability in vivo. To date, its effects on hydraulic conductivity (Lp) and…”
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Abnormal Centrifugal Axons in Streptozotocin- Diabetic Rat Retinas by Gastinger, Matthew J, Barber, Alistair J, Khin, Sonny A, McRill, Connie S, Gardner, Thomas W, Marshak, David W

“…To characterize the effects of diabetes on the expression of histidine decarboxylase mRNA and on the morphology of the histaminergic centrifugal axons in the…”
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Effect of VEGF on Retinal Microvascular Endothelial Hydraulic Conductivity: The Role of NO by Lakshminarayanan, Sunitha, Antonetti, David A, Gardner, Thomas W, Tarbell, John M

“…Vascular endothelial growth factor (VEGF) increases microvascular permeability in vivo and has been hypothesized to play a role in plasma leakage in diabetic…”
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Altered Expression of Retinal Occludin and Glial Fibrillary Acidic Protein in Experimental Diabetes by Barber, Alistair J, Antonetti, David A, Gardner, Thomas W

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Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors by Antonetti, D A, Barber, A J, Hollinger, L A, Wolpert, E B, Gardner, T W

“…Vascular endothelial growth factor (VEGF) may have a physiologic role in regulating vessel permeability and contributes to the pathophysiology of diabetic…”
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Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content : Vascular endothelial growth factor decreases occludin in retinal endothelial cells by ANTONETTI, D. A, BARBER, A. J, KHIN, S, LIETH, E, TARBELL, J. M, GARDNER, T. W

“…Blood-retinal barrier (BRB) breakdown is a hallmark of diabetic retinopathy, but the molecular changes that cause this pathology are unclear. Occludin is a…”
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Insulin Rescues Retinal Neurons from Apoptosis by a Phosphatidylinositol 3-Kinase/Akt-mediated Mechanism That Reduces the Activation of Caspase-3 by Barber, Alistair J., Nakamura, Makoto, Wolpert, Ellen B., Reiter, Chad E.N., Seigel, Gail M., Antonetti, David A., Gardner, Thomas W.

“…The ability of insulin to protect neurons from apoptosis was examined in differentiated R28 cells, a neural cell line derived from the neonatal rat retina…”
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A multistep validation process of biomarkers for preclinical drug development by Freeman, W M, Bixler, G V, Brucklacher, R M, Lin, C-M, Patel, K M, VanGuilder, H D, LaNoue, K F, Kimball, S R, Barber, A J, Antonetti, D A, Gardner, T W, Bronson, S K

“…Biomarkers that can be measured in preclinical models in a high-throughput, reproducible manner offer the potential to increase the speed and efficacy of drug…”
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Rates of weathering rind formation on Costa Rican basalt by Sak, P B, Fisher, D M, Gardner, T W, Murphy, K, Brantley, S L

“…Weathering rind thicknesses were measured on similar to 200 basaltic clasts collected from three regionally extensive alluvial fill terraces (Qt 1, Qt 2, and…”
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Excessive Hexosamines Block the Neuroprotective Effect of Insulin and Induce Apoptosis in Retinal Neurons by Nakamura, Makoto, Barber, Alistair J., Antonetti, David A., LaNoue, Kathryn F., Robinson, Katherine A., Buse, Maria G., Gardner, Thomas W.

“…In addition to microvascular abnormalities, neuronal apoptosis occurs early in diabetic retinopathy, but the mechanism is unknown. Insulin may act as a…”
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Diabetic retinopathy by Neely, K A, Quillen, D A, Schachat, A P, Gardner, T W, Blankenship, G W

“…Nonproliferative diabetic retinopathy may cause visual loss when associated with macular edema or macular ischemia (secondary to retinal capillary…”
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