Search Results - "Gardner, Joanne"
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Mesothelioma tumor cells modulate dendritic cell lipid content, phenotype and function
Published in PloS one (17-04-2015)“…Dendritic cells (DCs) play an important role in the generation of anti-cancer immune responses, however there is evidence that DCs in cancer patients are…”
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Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation
Published in PloS one (13-04-2018)“…There is evidence that dendritic cells (DCs) undergo age-related changes that modulate their function with their key role being priming antigen-specific…”
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Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules
Published in Ageing research reviews (01-09-2017)“…Dendritic cells (DCs) undergo continuous changes throughout life, and there is evidence that elderly DCs have a reduced capacity to stimulate T cells, which…”
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Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia
Published in Frontiers in genetics (06-11-2018)“…Most cancers emerge in the elderly, including lung cancer and mesothelioma, yet the elderly remain an underrepresented population in pre-clinical cancer…”
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Murine mesothelioma induces locally-proliferating IL-10+TNF-α+CD206−CX3CR1+ M3 macrophages that can be selectively depleted by chemotherapy or immunotherapy
Published in Oncoimmunology (02-06-2016)“…We used a murine model to monitor changes to myeloid cell subsets, i.e., myeloid-derived suppressor cells (MDSCs), M1 macrophages that secrete pro-inflammatory…”
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CD8+ cytotoxic T cell responses to dominant tumor-associated antigens are profoundly weakened by aging yet subdominant responses retain functionality and expand in response to chemotherapy
Published in Oncoimmunology (03-04-2019)“…Increasing life expectancy is associated with increased cancer incidence, yet the effect of cancer and anti-cancer treatment on elderly patients and their…”
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The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy
Published in Frontiers in medicine (30-11-2018)“…Aging is associated with an increased incidence of cancer. One contributing factor could be modulation of immune cells responsible for anti-tumor responses,…”
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Lipid-laden partially-activated plasmacytoid and CD4(-)CD8α(+) dendritic cells accumulate in tissues in elderly mice
Published in Immunity & ageing (29-07-2014)“…Aging is associated with a decline in lymphocyte function however, little is known about dendritic cell (DC) subsets and aging. Aging is also associated with…”
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Elderly dendritic cells respond to LPS/IFN-[gamma] and CD40L stimulation despite incomplete maturation
Published in PloS one (13-04-2018)“…There is evidence that dendritic cells (DCs) undergo age-related changes that modulate their function with their key role being priming antigen-specific…”
Get full text
Journal Article -
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Lack of multidisciplinary collaboration is a barrier to outcomes research
Published in Journal of the American Dietetic Association (2002)“…Objectives To identify and describe methods of collaboration used by dietitians to conduct outcomes research and to identify perceived barriers to…”
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Journal Article -
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Lipid-laden partially-activated plasmacytoid and CD4-CD8[alpha]+ dendritic cells accumulate in tissues in elderly mice
Published in Immunity & ageing (29-07-2014)“…Background Aging is associated with a decline in lymphocyte function however, little is known about dendritic cell (DC) subsets and aging. Aging is also…”
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Journal Article -
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Lipid-laden partially-activated plasmacytoid and CD4 super(-)CD8[alpha] super(+) dendritic cells accumulate in tissues in elderly mice
Published in Immunity & ageing (01-01-2014)“…Background: Aging is associated with a decline in lymphocyte function however, little is known about dendritic cell (DC) subsets and aging. Aging is also…”
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13
Odyssean perspectives on trauma
Published 01-01-2019“…The question of whether trauma has a place in studies of the ancient world deserves fresh consideration. In the past, scholars such as Tritle (2000; 2014) have…”
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Dissertation -
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Genotype-Phenotype Correlation in Sickle Cell Disease
Published 01-01-2017“…Sickle cell disease (SCD) has a complex pathophysiology initiated by the polymerisation of deoxy-sickle-haemoglobin. The single nucleotide change underpinning…”
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Is Age a Barrier to the Aggressive Treatment of Ovarian Cancer with Paclitaxel and Carboplatin?
Published in Gynecologic oncology (01-12-1999)“…Objective. The objective of this study was to determine whether the toxicities associated with chemotherapy are age related in women treated for ovarian…”
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A note on syntactic relationships in nonfluency
Published in Journal of speech and hearing research (01-12-1968)Get more information
Journal Article -
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The implications of wicked problems for the legitimacy of european environmental policy development : the case of environmental risks from the pharmaceutical endocrine disrupter, 17α-ethinyl oestradiol, under the european water framework directive
Published 01-01-2018“…The issue of environmental risks from the pharmaceutical endocrine disrupter 17 alpha-ethinyl oestradiol (EE2), which is an active ingredient in the…”
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Dissertation -
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Posterior alpha-wave characteristics of eidetic children
Published in Psychophysiology (01-09-1974)Get more information
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The vampire in English literature
Published 01-01-1991“…The vampires in English literature, including film, can be divided into four eras by character, and are distinct from the vampires of European folklore. The…”
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Dissertation