Search Results - "Gardner, Jason D."

Nicotine and the renin-angiotensin system by Oakes, Joshua M, Fuchs, Robert M, Gardner, Jason D, Lazartigues, Eric, Yue, Xinping

“…Cigarette smoking is the single most important risk factor for the development of cardiovascular and pulmonary diseases (CVPD). Although cigarette smoking has…”
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Effects of Chronic Nicotine Inhalation on Systemic and Pulmonary Blood Pressure and Right Ventricular Remodeling in Mice by Oakes, Joshua M., Xu, Jiaxi, Morris, Tamara M., Fried, Nicholas D., Pearson, Charlotte S., Lobell, Thomas D., Gilpin, Nicholas W., Lazartigues, Eric, Gardner, Jason D., Yue, Xinping

“…Cigarette smoking is the single most important risk factor for the development of cardiovascular and pulmonary diseases; however, the role of nicotine in the…”
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Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling by Voloshenyuk, Tetyana G., Landesman, Elizabeth S., Khoutorova, Elena, Hart, Andrew D., Gardner, Jason D.

“…► Lysyl oxidase (LOX) is a critical enzyme for collagen cross-linking. ► Rat cardiac fibroblasts were used to study TGF-β1 regulation of LOX. ► TGF-β1…”
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Alcohol abuse: critical pathophysiological processes and contribution to disease burden by Molina, Patricia E, Gardner, Jason D, Souza-Smith, Flavia M, Whitaker, Annie M

“…Alcohol abuse; the most common and costly form of drug abuse, is a major contributing factor to many disease categories. The alcohol-attributable disease…”
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Estrogen improves TIMP-MMP balance and collagen distribution in volume-overloaded hearts of ovariectomized females by Voloshenyuk, Tetyana G, Gardner, Jason D

“…Our previous studies demonstrate that 17beta-estradiol limits chronic volume overload-induced hypertrophy and improves heart function in ovariectomized rats…”
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Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK by Siddesha, Jalahalli M, Valente, Anthony J, Sakamuri, Siva S.V.P, Yoshida, Tadashi, Gardner, Jason D, Somanna, Naveen, Takahashi, Chiaki, Noda, Makoto, Chandrasekar, Bysani

“…Abstract Sustained induction and activation of matrixins (matrix metalloproteinases or MMPs), and the destruction and deposition of extracellular matrix (ECM),…”
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Genetic Disruption of Guanylyl Cyclase/Natriuretic Peptide Receptor-A Triggers Differential Cardiac Fibrosis and Disorders in Male and Female Mutant Mice: Role of TGF-β1/SMAD Signaling Pathway by Subramanian, Umadevi, Ramasamy, Chandramohan, Ramachandran, Samivel, Oakes, Joshua M, Gardner, Jason D, Pandey, Kailash N

“…The global targeted disruption of the natriuretic peptide receptor-A (NPRA) gene ( ) in mice provokes hypertension and cardiovascular dysfunction. The…”
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Interleukin-17A stimulates cardiac fibroblast proliferation and migration via negative regulation of the dual-specificity phosphatase MKP-1/DUSP-1 by Valente, Anthony J., Yoshida, Tadashi, Gardner, Jason D., Somanna, Naveen, Delafontaine, Patrice, Chandrasekar, Bysani

“…The dual-specificity mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) inactivates MAP kinases by dephosphorylation. Here we show that the…”
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Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction by Whitehead, Anna K, Fried, Nicholas D, Li, Zhen, Neelamegam, Kandasamy, Pearson, Charlotte S, LaPenna, Kyle B, Sharp, Thomas E, Lefer, David J, Lazartigues, Eric, Gardner, Jason D, Yue, Xinping

“…Cigarette smoking remains the leading modifiable risk factor for cardiopulmonary diseases; however, the effects of nicotine alone on cardiopulmonary function…”
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H2S Prodrug, SG-1002, Protects against Myocardial Oxidative Damage and Hypertrophy In Vitro via Induction of Cystathionine β-Synthase and Antioxidant Proteins by Islam, Rahib K., Donnelly, Erinn, Donnarumma, Erminia, Hossain, Fokhrul, Gardner, Jason D., Islam, Kazi N.

“…Endogenously produced hydrogen sulfide (H2S) is critical for cardiovascular homeostasis. Therapeutic strategies aimed at increasing H2S levels have proven…”
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The relationship between myocardial extracellular matrix remodeling and ventricular function by Brower, Gregory L., Gardner, Jason D., Forman, Mary F., Murray, David B., Voloshenyuk, Tetyana, Levick, Scott P., Janicki, Joseph S.

“…Elevations in myocardial stress initiate structural remodeling of the heart in an attempt to normalize the imposed stress. This remodeling consists of…”
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Nicotine Downregulates the Compensatory Angiotensin-Converting Enzyme 2/Angiotensin Type 2 Receptor of the Renin-Angiotensin System by Yue, Xinping, Basting, Tyler M, Flanagan, Thomas W, Xu, Jiaxi, Lobell, Thomas D, Gilpin, Nicholas W, Gardner, Jason D, Lazartigues, Eric

“…Smoking is a major risk factor for the development of cardiovascular and pulmonary diseases. The importance of the renin-angiotensin system in the development…”
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Acetylsalicylic Acid Inhibits IL-18-Induced Cardiac Fibroblast Migration Through the Induction of RECK by Siddesha, Jalahalli M., Valente, Anthony J., Sakamuri, Siva S.V.P., Gardner, Jason D., Delafontaine, Patrice, Noda, Makoto, Chandrasekar, Bysani

“…The pathogenesis of cardiac fibrosis and adverse remodeling is thought to involve the ROS‐dependent induction of inflammatory cytokines and matrix…”
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Nicotine and novel tobacco products drive adverse cardiac remodeling and dysfunction in preclinical studies by Fried, Nicholas D, Oakes, Joshua M, Whitehead, Anna K, Lazartigues, Eric, Yue, Xinping, Gardner, Jason D

“…The heart undergoes structural and functional changes in response to injury and hemodynamic stress known as cardiac remodeling. Cardiac remodeling often…”
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Alcohol Modulation of Cardiac Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of MMPs Favors Collagen Accumulation by El Hajj, Elia C., El Hajj, Milad C., Voloshenyuk, Tetyana G., Mouton, Alan J., Khoutorova, Elena, Molina, Patricia E., Gilpin, Nicholas W., Gardner, Jason D.

“…Background Chronic alcohol consumption has been shown in human and animal studies to result in collagen accumulation, myocardial fibrosis, and heart failure…”
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Abstinence Restores Cardiac Function in Mice with Established Alcohol-Induced Cardiomyopathy by Edavettal, Joshua M, Harris, Nicholas R, Cohen, Sarah E, Paloczi, Janos, Chandrasekar, Bysani, Gardner, Jason D

“…Alcohol-induced cardiomyopathy (ACM) has a poor prognosis with up to a 50% chance of death within four years of diagnosis. There are limited studies…”
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A novel experimental model of erectile dysfunction in rats with heart failure using volume overload by Silva, Fábio Henrique, Veiga, Frederico José Reis, Mora, Aline Gonçalves, Heck, Rodrigo Sader, De Oliveira, Caroline Candida, Gambero, Alessandra, Franco-Penteado, Carla Fernanda, Antunes, Edson, Gardner, Jason D, Priviero, Fernanda Bruschi Marinho, Claudino, Mário Angelo

“…Patients with heart failure (HF) display erectile dysfunction (ED). However, the pathophysiology of ED during HF remains poorly investigated. This study aimed…”
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Heat-not-burn tobacco products: an emerging threat to cardiovascular health by Fried, Nicholas D, Gardner, Jason D

“…Cigarette smoking is at all-time lows globally, but the use of electronic cigarettes has increased profoundly. Recent reports of electronic cigarette or vaping…”
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Protection from adverse myocardial remodeling secondary to chronic volume overload in mast cell deficient rats by Levick, Scott P, Gardner, Jason D, Holland, Merrilee, Hauer-Jensen, Martin, Janicki, Joseph S, Brower, Gregory L

“…Abstract Mast cells have diverse roles throughout the body as evidenced by their heterogeneous nature. In the heart, cardiac mast cells have been implicated in…”
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Leptin Actions on Food Intake and Body Temperature Are Mediated by IL-1 by Luheshi, Giamal N., Gardner, Jason D., Rushforth, David A., Loudon, Andrew S., Rothwell, Nancy J.

“…Leptin regulates energy balance through its actions in the brain on appetite and energy expenditure and also shares properties with cytokines such as IL-1. We…”
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