Search Results - "Gardiner, T H"

Two-generation reproduction toxicity study with isopropanol in rats by Bevan, C, Tyler, T R, Gardiner, T H, Kapp, Jr, R W, Andrews, L, Beyer, B K

“…A two-generation reproduction toxicity study was conducted in rats with isopropanol. Thirty rats of each sex per group (P1) were dosed once daily by oral…”
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Isopropanol: Summary of TSCA Test Rule Studies and Relevance to Hazard Identification by Kapp, Jr, Robert W., Bevan, Christopher, Gardiner, Thomas H., Banton, Marcy I., Tyler, Tipton R., Wright, Gary A.

“…The toxicity of isopropanol (IPA) has been extensively studied as a result of a Test Rule under Section 4 of the Toxic Substances Control Act. In general, the…”
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Isopropanol: acute vapor inhalation neurotoxicity study in rats by Gill, M W, Burleigh-Flayer, H D, Strother, D E, Masten, L W, McKee, R H, Tyler, T R, Gardiner, T H

“…Five groups of 25 Fischer 344 rats of each sex were exposed for 6 h to isopropanol vapor at 0, 500, 1500, 5000 or 10,000 ppm. Behavioral observations for 10…”
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Glycidyloxy compounds used in epoxy resin systems: a toxicology review by Gardiner, T H, Waechter, Jr, J M, Wiedow, M A, Solomon, W T

“…The glycidyloxy compounds constitute an important group of chemicals used extensively in the formulation of epoxy resin systems employed in coatings,…”
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Quantitative changes in permeability of rat lung epithelium in lung edema by Gardiner, T H

“…The pulmonary absorption of 14C-labeled urea, mannitol, inulin, and dextran was measured in vivo in anesthetized rats with alpha-naphthylthiourea…”
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In vitro and in vivo assays of isopropanol for mutagenicity by Kapp, Jr, R W, Marino, D J, Gardiner, T H, Masten, L W, McKee, R H, Tyler, T R, Ivett, J L, Young, R R

“…To assess the mutagenic potential of isopropanol, an in vitro Chinese hamster ovary (CHO) cell/HGPRT gene mutation assay and a bone marrow micronucleus study…”
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Pyrethroid-mediated skin sensory stimulation characterized by a new behavioral paradigm by Cagen, S Z, Malley, L A, Parker, C M, Gardiner, T H, Van Gelder, G A, Jud, V A

“…Occupational exposures to pyrethroids have been associated with skin sensory effects characterized by transient itching/tingling sensations. This effect had…”
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Active transport of phenol red by rat lung slices by Gardiner, T H, Schanker, L S

“…32S-phenol red was taken up by rat lung slices incubated in oxygenated Krebs-Ringer phosphate-glucose solution (pH 7.4) at 37 degrees C by a process showing…”
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Effect of vitamin E and other amelioratory agents on the fenvalerate-mediated skin sensation by Malley, L A, Cagen, S Z, Parker, C M, Gardiner, T H, van Gelder, G A, Rose, G P

“…Previous investigations have demonstrated that dermal exposure to fenvalerate or other synthetic pyrethroid insecticides can produce a skin sensory response…”
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Comparison of uptake and binding of disodium cromoglycate and phenol red in rat lung by Gardiner, T H, Goodman, F R

“…In rat lung slices 3H-disodium cromoglycate (3H-DSCG) (0.001 mM) was taken up rapidly and 3H-DSCG tissue spaces, which equilibrated by 30 minutes, remained…”
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Distribution of clozapine in the rat: localization in lung by Gardiner, T H, Lewis, J M, Shore, P A

“…To determine the distribution of the antipsychotic agent, clozapin (CLZ), a fluorometric procedure for its estimation was devised, and the drug was measured in…”
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Effect of pulmonary edema on drug transport and binding in rat lung by Gardiner, T H, Goodman, F R

“…The pulmonary absorption and uptake of (35S)phenol red ((35S)PR was measured in anesthetized rats with alpha-naphthylthiourea- (ANTU) induced lung edema. When…”
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Developmental toxicity evaluation of isopropanol by gavage in rats and rabbits by Tyl, R W, Masten, L W, Marr, M C, Myers, C B, Slauter, R W, Gardiner, T H, Strother, D E, McKee, R H, Tyler, T R

“…Timed-pregnant CD (Sprague-Dawley) rats, 25/group, were dosed orally with aqueous isopropanol (IPA; CAS No. 67-63-0) solutions at 0, 400, 800, or 1200…”
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Effect of paraquat-induced lung damage on permeability of rat lung to drugs by Gardiner, T H, Schanker, L S

“…To investigate the effect of paraquat-induced lung damage on pulmonary absorption of drugs, rats were given a single oral dose of paraquat (250 mg/kg), and…”
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Effect of papain-induced emphysema on permeability of rat lung to drugs by Gardiner, T H, Schanker, L S

“…To investigate the effect of a papain-induced emphysema-like condition on pulmonary absorption of drugs, rats were exposed to either papain aerosol or…”
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Subchronic feeding study of decarboxyfenvalerate in rats by Parker, C M, Wimberly, H C, Lam, A S, Gardiner, T H, Van Gelder, G A

“…Groups of 30 male and 30 female Fischer-344 rats were fed dietary concentrations of 0, 30, 100, 300, 3000, or 10,000 ppm decarboxyfenvalerate (DC-FEN) for up…”
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Cyanide concentrations in blood after amygdalin (laetrile) administration in rats by McAnalley, B H, Gardiner, T H, Garriott, J C

“…Toxic amounts of cyanide are released into the blood of rats following the oral administration of amygdalin (laetrile); cyanide blood concentrations and…”
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Enhanced pulmonary absorption of drugs in rats with experimental silicosis by Gardiner, T H, Schanker, L S

“…To investigate the effect of pulmonary silicosis on absorption of drugs from the lung, rats were given an intratracheal injection of 50 mg quartz dust, and…”
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Effect of oxygen toxicity and nitric acid-induced lung damage on drug absorption from the rat lung by Gardiner, T H, Schanker, L S

“…To investigate the effect of pulmonary oxygen toxicity and nitric acid-induced lung damage on absorption of drugs from the lung, rats were either exposed…”
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Disposition and pharmacokinetics of isopropanol in F-344 rats and B6C3F1 mice by Slauter, R W, Coleman, D P, Gaudette, N F, McKee, R H, Masten, L W, Gardiner, T H, Strother, D E, Tyler, T R, Jeffcoat, A R

“…The absorption, metabolism, disposition, and excretion of isopropanol (IPA) were studied in male and female rats and mice. Animals were exposed by i.v. (300…”
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