Search Results - "Gardiner, S M."

Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia by Lowry, P. J, Page, N. M, Woods, R. J, Gardiner, S. M, Lomthaisong, K, Gladwell, R. T, Butlin, D. J, Manyonda, I. T

“…Pre-eclampsia is a principal cause of maternal morbidity and mortality, affecting 5-10% of first pregnancies worldwide. Manifestations include increased blood…”
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Possible involvement of GLP‐1(9–36) in the regional haemodynamic effects of GLP‐1(7–36) in conscious rats by Gardiner, SM, March, JE, Kemp, PA, Bennett, T, Baker, DJ

“…BACKGROUND AND PURPOSE The incretin hormone, glucagon‐like peptide (GLP)‐1(7–36), is rapidly cleaved by dipeptidyl peptidase 4 (DPP‐4) into GLP‐1(9–36), and…”
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Temporal changes in the involvement of pyruvate dehydrogenase complex in muscle lactate accumulation during lipopolysaccharide infusion in rats by Alamdari, N, Constantin-Teodosiu, D, Murton, A J, Gardiner, S M, Bennett, T, Layfield, R, Greenhaff, P L

“…A characteristic manifestation of sepsis is muscle lactate accumulation. This study examined any putative (causative) association between pyruvate…”
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Mechanisms involved in the regional haemodynamic effects of intermedin (adrenomedullin 2) compared with adrenomedullin in conscious rats by Jolly, L, March, JE, Kemp, PA, Bennett, T, Gardiner, SM

“…Background and purpose:  Intermedin (IMD) is a newly identified member of the calcitonin family of peptides that shares structural and functional homology with…”
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Depressor and regionally‐selective vasodilator effects of human and rat urotensin II in conscious rats by Gardiner, S M, March, J E, Kemp, P A, Davenport, A P, Bennett, T

“…The regional haemodynamic effects of rat or human urotensin II (U‐II) 3, 30, 300 and 3000 pmol kg−1, i.v.) were assessed in separate groups of conscious,…”
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Factors influencing the regional haemodynamic responses to methanandamide and anandamide in conscious rats by Gardiner, SM, March, JE, Kemp, PA, Bennett, T

“…Background and purpose:  In vitro evidence suggests that metabolism of anandamide by cyclooxygenase‐2 (COX‐2) may be more important when the primary metabolic…”
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Autonomic nervous system‐dependent and ‐independent cardiovascular effects of exendin‐4 infusion in conscious rats by Gardiner, S M, March, J E, Kemp, P A, Bennett, T

“…Background and purpose: Glucagon‐like peptide‐1 (GLP) receptor agonists are promising therapeutic agents for the treatment of type II diabetes, but effects…”
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Regional haemodynamic effects of cyclosporine A, tacrolimus and sirolimus in conscious rats by Gardiner, S M, March, J E, Kemp, P A, Fallgren, B, Bennett, T

“…The observation that the immunosuppressants, cyclosporine A (CsA) and tacrolimus, have pressor effects, but sirolimus does not, has led to an hypothesis that…”
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Complex regional haemodynamic effects of anandamide in conscious rats by Gardiner, S M, March, J E, Kemp, P A, Bennett, T

“…Experiments were carried out in conscious, chronically instrumented, male, Sprague‐Dawley rats to delineate the regional haemodynamic effects of the putative…”
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Regional haemodynamic responses to adenosine receptor activation vary across time following lipopolysaccharide treatment in conscious rats by Jolly, L, March, J E, Kemp, P A, Bennett, T, Gardiner, S M

“…Background and purpose: Studies using adenosine receptor antagonists have shown that adenosine‐mediated vasodilatations play an important role in the…”
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A comparison between the cardiovascular actions of urocortin 1 and urocortin 2 (stresscopin-related peptide) in conscious rats by Gardiner, S M, March, J E, Kemp, P A, Bennett, T

“…The aims of the study were, in conscious Sprague-Dawley rats, to compare the effects of stresscopin-related peptide (SRP) and urocortin (UCN) 1 on blood…”
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Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro by Wheal, A J, Bennett, T, Randall, M D, Gardiner, S M

“…Background and purpose: Since the vasorelaxant potency of the endocannabinoid anandamide is enhanced in perfused mesenteric vascular beds from rats made…”
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Evaluation of two carrier protein–angiotensin I conjugate vaccines to assess their future potential to control high blood pressure (hypertension) in man by Downham, M. R., Auton, T. R., Rosul, A., Sharp, H. L., Sjöström, L., Rushton, A., Richards, J. P., Mant, T. G. K., Gardiner, S. M., Bennett, T., Glover, J. F.

“…Aims  We aim to modulate the renin–angiotensin system (RAS) by active immunization against angiotensin I hormone (AI), potentially providing a novel conjugate…”
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Regional haemodynamic responses to the cannabinoid agonist, WIN 55212‐2, in conscious, normotensive rats, and in hypertensive, transgenic rats by Gardiner, S M, March, J E, Kemp, P A, Bennett, T

“…Regional haemodynamic responses to the cannabinoid agonist, WIN 55212‐2 (5 – 250 μg kg−1 i.v.) were assessed in conscious, normotensive, Hannover,…”
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Control of Regional Blood Flow by Endothelium-Derived Nitric Oxide by Gardiner, Sheila M, Compton, Alix M, Bennett, Terence, Palmer, Richard M.J, Moncada, Salvador

“…The regional hemodynamic consequences of inhibiting vascular endothelial nitric oxide generation with N-monomethyl-L-arginine (L-NMMA) were studied in…”
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Regional and temporal changes in cardiovascular responses to norepinephrine and vasopressin during continuous infusion of lipopolysaccharide in conscious rats by Bennett, T., Mahajan, R.P., March, J.E., Kemp, P.A., Gardiner, S.M.

“…Reduced pressor responsiveness to norepinephrine (NE) in sepsis is well documented but the associated regional haemodynamic changes are less well…”
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Effects of nitric oxide synthase inhibition with or without cyclooxygenase‐2 inhibition on resting haemodynamics and responses to exendin‐4 by Gardiner, S M, March, J E, Kemp, P A, Bennett, T

“…Background and purpose: Interactions between the NO system and the cyclooxygenase systems may be important in cardiovascular regulation. Here we measured the…”
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Regional haemodynamic responses to infusion of lipopolysaccharide in conscious rats: effects of pre‐ or post‐treatment with glibenclamide by Gardiner, S M, Kemp, P A, March, J E, Bennett, T

“…To determine the putative contribution of KATP‐channels to the haemodynamic sequelae of endotoxaemia, three experiments were carried out in different groups of…”
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Haemodynamic effects of the bacterial quorum sensing signal molecule, N‐(3‐oxododecanoyl)‐L‐homoserine lactone, in conscious, normal and endotoxaemic rats by Gardiner, S M, Chhabra, S R, Harty, C, Williams, P, Pritchard, D I, Bycroft, B W, Bennett, T

“…N‐acylhomoserine lactones (AHLs) are small, diffusible signalling molecules, employed by Gram‐negative bacteria to coordinate gene expression with cell…”
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Regional hemodynamic effects of neutral endopeptidase inhibition and angiotensin (AT(1)) receptor antagonism alone or in combination in conscious spontaneously hypertensive rats by Gardiner, S M, March, J E, Kemp, P A, Ballard, S A, Bennett, T

“…We tested the hypothesis that angiotensin (AT(1)) receptor antagonism (with losartan) would enhance the cardiovascular actions of neutral endopeptidase (NEP)…”
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