Search Results - "Gardiner, Laura"

A genome-wide survey of DNA methylation in hexaploid wheat by Gardiner, Laura-Jayne, Quinton-Tulloch, Mark, Olohan, Lisa, Price, Jonathan, Hall, Neil, Hall, Anthony

“…DNA methylation is an important mechanism of epigenetic gene expression control that can be passed between generations. Here, we use sodium bisulfite treatment…”
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Understanding DNA Methylation Patterns in Wheat by Gardiner, Laura-Jayne

“…The bread wheat genome is large (17 Gb), allohexaploid, and highly repetitive (80-90% of the genome), which makes genomic and epigenomic analyses expensive to…”
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Elucidating the genetic basis of biomass accumulation and radiation use efficiency in spring wheat and its role in yield potential by Molero, Gemma, Joynson, Ryan, Pinera‐Chavez, Francisco J., Gardiner, Laura‐Jayne, Rivera‐Amado, Carolina, Hall, Anthony, Reynolds, Matthew P.

“…Summary One of the major challenges for plant scientists is increasing wheat (Triticum aestivum) yield potential (YP). A significant bottleneck for increasing…”
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Explainable AI reveals changes in skin microbiome composition linked to phenotypic differences by Carrieri, Anna Paola, Haiminen, Niina, Maudsley-Barton, Sean, Gardiner, Laura-Jayne, Murphy, Barry, Mayes, Andrew E., Paterson, Sarah, Grimshaw, Sally, Winn, Martyn, Shand, Cameron, Hadjidoukas, Panagiotis, Rowe, Will P. M., Hawkins, Stacy, MacGuire-Flanagan, Ashley, Tazzioli, Jane, Kenny, John G., Parida, Laxmi, Hoptroff, Michael, Pyzer-Knapp, Edward O.

“…Alterations in the human microbiome have been observed in a variety of conditions such as asthma, gingivitis, dermatitis and cancer, and much remains to be…”
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Analysis of the recombination landscape of hexaploid bread wheat reveals genes controlling recombination and gene conversion frequency by Gardiner, Laura-Jayne, Wingen, Luzie U, Bailey, Paul, Joynson, Ryan, Brabbs, Thomas, Wright, Jonathan, Higgins, James D, Hall, Neil, Griffiths, Simon, Clavijo, Bernardo J, Hall, Anthony

“…Sequence exchange between homologous chromosomes through crossing over and gene conversion is highly conserved among eukaryotes, contributing to genome…”
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Using human in vitro transcriptome analysis to build trustworthy machine learning models for prediction of animal drug toxicity by Gardiner, Laura-Jayne, Carrieri, Anna Paola, Wilshaw, Jenny, Checkley, Stephen, Pyzer-Knapp, Edward O., Krishna, Ritesh

“…During the development of new drugs or compounds there is a requirement for preclinical trials, commonly involving animal tests, to ascertain the safety of the…”
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Uncovering candidate genes involved in photosynthetic capacity using unexplored genetic variation in Spring Wheat by Joynson, Ryan, Molero, Gemma, Coombes, Benedict, Gardiner, Laura‐Jayne, Rivera‐Amado, Carolina, Piñera‐Chávez, Francisco J., Evans, John R., Furbank, Robert T., Reynolds, Matthew P., Hall, Anthony

“…Summary To feed an ever‐increasing population we must leverage advances in genomics and phenotyping to harness the variation in wheat breeding populations for…”
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A haplotype map of allohexaploid wheat reveals distinct patterns of selection on homoeologous genomes by Jordan, Katherine W, Wang, Shichen, Lun, Yanni, Gardiner, Laura-Jayne, MacLachlan, Ron, Hucl, Pierre, Wiebe, Krysta, Wong, Debbie, Forrest, Kerrie L, Sharpe, Andrew G, Sidebottom, Christine Hd, Hall, Neil, Toomajian, Christopher, Close, Timothy, Dubcovsky, Jorge, Akhunova, Alina, Talbert, Luther, Bansal, Urmil K, Bariana, Harbans S, Hayden, Matthew J, Pozniak, Curtis, Jeddeloh, Jeffrey A, Hall, Anthony, Akhunov, Eduard

“…Bread wheat is an allopolyploid species with a large, highly repetitive genome. To investigate the impact of selection on variants distributed among…”
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Combining explainable machine learning, demographic and multi-omic data to inform precision medicine strategies for inflammatory bowel disease by Gardiner, Laura-Jayne, Carrieri, Anna Paola, Bingham, Karen, Macluskie, Graeme, Bunton, David, McNeil, Marian, Pyzer-Knapp, Edward O

“…Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn's disease, affect several million individuals worldwide. These diseases are…”
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Hidden variation in polyploid wheat drives local adaptation by Gardiner, Laura-Jayne, Joynson, Ryan, Omony, Jimmy, Rusholme-Pilcher, Rachel, Olohan, Lisa, Lang, Daniel, Bai, Caihong, Hawkesford, Malcolm, Salt, David, Spannagl, Manuel, Mayer, Klaus F X, Kenny, John, Bevan, Michael, Hall, Neil, Hall, Anthony

“…Wheat has been domesticated into a large number of agricultural environments and has the ability to adapt to diverse environments. To understand this process,…”
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A framework for gene mapping in wheat demonstrated using the Yr7 yellow rust resistance gene by Gardiner, Laura-Jayne, Bansept-Basler, Pauline, El-Soda, Mohamed, Hall, Anthony, O'Sullivan, Donal M

“…We used three approaches to map the yellow rust resistance gene Yr7 and identify associated SNPs in wheat. First, we used a traditional QTL mapping approach…”
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Mapping‐by‐sequencing in complex polyploid genomes using genic sequence capture: a case study to map yellow rust resistance in hexaploid wheat by Gardiner, Laura‐Jayne, Bansept‐Basler, Pauline, Olohan, Lisa, Joynson, Ryan, Brenchley, Rachel, Hall, Neil, O'Sullivan, Donal M., Hall, Anthony

“…Summary Previously we extended the utility of mapping‐by‐sequencing by combining it with sequence capture and mapping sequence data to pseudo‐chromosomes that…”
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Interpreting machine learning models to investigate circadian regulation and facilitate exploration of clock function by Gardiner, Laura-Jayne, Rusholme-Pilcher, Rachel, Colmer, Josh, Rees, Hannah, Crescente, Juan Manuel, Carrieri, Anna Paola, Duncan, Susan, Pyzer-Knapp, Edward O., Krishna, Ritesh, Hall, Anthony

“…The circadian clock is an important adaptation to life on Earth. Here, we use machine learning to predict complex, temporal, and circadian gene expression…”
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Bluster or Lustre: Can AI Improve Crops and Plant Health? by Gardiner, Laura-Jayne, Krishna, Ritesh

“…In a changing climate where future food security is a growing concern, researchers are exploring new methods and technologies in the effort to meet ambitious…”
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Using genic sequence capture in combination with a syntenic pseudo genome to map a deletion mutant in a wheat species by Gardiner, Laura‐Jayne, Gawroński, Piotr, Olohan, Lisa, Schnurbusch, Thorsten, Hall, Neil, Hall, Anthony

“…Mapping‐by‐sequencing analyses have largely required a complete reference sequence and employed whole genome re‐sequencing. In species such as wheat, no…”
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Conservation genetics of the eastern yellow-bellied racer (Coluber constrictor flaviventris) and bullsnake (Pituophis catenifer sayi): River valleys are critical features for snakes at northern range limits by Somers, Christopher M, Graham, Carly F, Martino, Jessica A, Frasier, Timothy R, Lance, Stacey L, Gardiner, Laura E, Poulin, Ray G

“…On the North American Great Plains, several snake species reach their northern range limit where they rely on sparsely distributed hibernacula located in major…”
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Integrating genomic resources to present full gene and putative promoter capture probe sets for bread wheat by Gardiner, Laura-Jayne, Brabbs, Thomas, Akhunov, Alina, Jordan, Katherine, Budak, Hikmet, Richmond, Todd, Singh, Sukhwinder, Catchpole, Leah, Akhunov, Eduard, Hall, Anthony

“…Whole-genome shotgun resequencing of wheat is expensive because of its large, repetitive genome. Moreover, sequence data can fail to map uniquely to the…”
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A modified sequence capture approach allowing standard and methylation analyses of the same enriched genomic DNA sample by Olohan, Lisa, Gardiner, Laura-Jayne, Lucaci, Anita, Steuernagel, Burkhard, Wulff, Brande, Kenny, John, Hall, Neil, Hall, Anthony

“…Bread wheat has a large complex genome that makes whole genome resequencing costly. Therefore, genome complexity reduction techniques such as sequence capture…”
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Identification of QTL and underlying genes for root system architecture associated with nitrate nutrition in hexaploid wheat by GRIFFITHS, Marcus, ATKINSON, Jonathan A., GARDINER, Laura-Jayne, SWARUP, Ranjan, POUND, Michael P., WILSON, Michael H., BENNETT, Malcolm J., WELLS, Darren M.

“…The root system architecture (RSA) of a crop has a profound effect on the uptake of nutrients and consequently the potential yield. However, little is known…”
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Re-purposing software for functional characterization of the microbiome by Gardiner, Laura-Jayne, Haiminen, Niina, Utro, Filippo, Parida, Laxmi, Seabolt, Ed, Krishna, Ritesh, Kaufman, James H

“…Widespread bioinformatic resource development generates a constantly evolving and abundant landscape of workflows and software. For analysis of the microbiome,…”
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