A Controlled Trial of Diazepam Administered during Febrile Illnesses to Prevent Recurrence of Febrile Seizures

Convulsions triggered by fever (febrile seizures) are the most common type of seizure, with a prevalence of 3 to 4 percent 1 . Febrile seizures frequently recur, with a recurrence rate of 33 percent overall and 50 percent when the first febrile seizure occurs before one year of age 1 . The risk of r...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 329; no. 2; pp. 79 - 84
Main Authors:	Rosman, N. Paul, Colton, Theodore, Labazzo, Jan, Gilbert, Paula L, Gardella, Nancy B, Kaye, Edward M, Van Bennekom, Carla, Winter, Michael R
Format:	Journal Article
Language:	English
Published:	Boston, MA Massachusetts Medical Society 08-07-1993
Subjects:	Administration, Oral Anticonvulsants. Antiepileptics. Antiparkinson agents Ataxia Biological and medical sciences Body weight Child, Preschool Children Children & youth Convulsions & seizures Diazepam Diazepam - administration & dosage Diazepam - adverse effects Diazepam - therapeutic use Double-Blind Method Drug Administration Schedule Drug dosages Epilepsy Families & family life Female Fever Fever - physiopathology Follow-Up Studies Humans Illnesses Infant Male Medical sciences Motivation Neurology Neuropharmacology Parents & parenting Patient Compliance Patient Dropouts Pediatrics Pharmacology. Drug treatments Phenobarbital Prevention Proportional Hazards Models Recurrence Seizures Seizures, Febrile - etiology Seizures, Febrile - prevention & control Side effects Survival Analysis Treatment Outcome Urine Human Prevention Nervous system diseases Chemotherapy Treatment Convulsion Oral administration Complication Anticonvulsant Child Fever
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Summary:	Convulsions triggered by fever (febrile seizures) are the most common type of seizure, with a prevalence of 3 to 4 percent 1 . Febrile seizures frequently recur, with a recurrence rate of 33 percent overall and 50 percent when the first febrile seizure occurs before one year of age 1 . The risk of recurrence increases when there is a family history of febrile seizures and, in some but not all studies, when there is a family history of afebrile seizures and when the child has a neurologic abnormality 2 , 3 . Half the recurrences occur within six months of the first febrile . . .
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM199307083290202