Search Results - "Garcin, Elsa D."

Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors by Miller, Thomas W, Amason, Joshua D, Garcin, Elsa D, Lamy, Laurence, Dranchak, Patricia K, Macarthur, Ryan, Braisted, John, Rubin, Jeffrey S, Burgess, Teresa L, Farrell, Catherine L, Roberts, David D, Inglese, James

“…CD47 is an immune checkpoint molecule that downregulates key aspects of both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα,…”
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A Dimer Interface Mutation in Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Its Binding to AU-rich RNA by White, Michael R., Khan, Mohd M., Deredge, Daniel, Ross, Christina R., Quintyn, Royston, Zucconi, Beth E., Wysocki, Vicki H., Wintrode, Patrick L., Wilson, Gerald M., Garcin, Elsa D.

“…Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an enzyme best known for its role in glycolysis. However, extra-glycolytic functions of GAPDH have been…”
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GAPDH as a model non-canonical AU-rich RNA binding protein by Garcin, Elsa D.

“…[Display omitted] Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays a key role in glycolysis but is also known for its involvement in a myriad of…”
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Structural Basis for Isozyme-specific Regulation of Electron Transfer in Nitric-oxide Synthase[boxs] by Garcin, Elsa D., Bruns, Christopher M., Lloyd, Sarah J., Hosfield, David J., Tiso, Mauro, Gachhui, Ratan, Stuehr, Dennis J., Tainer, John A., Getzoff, Elizabeth D.

“…Three nitric-oxide synthase (NOS) isozymes play crucial, but distinct, roles in neurotransmission, vascular homeostasis, and host defense, by catalyzing…”
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Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow by Rogers, Natasha M, Seeger, Franziska, Garcin, Elsa D, Roberts, David D, Isenberg, Jeffrey S

“…Nitric oxide (NO) maintains cardiovascular health by activating soluble guanylate cyclase (sGC) to increase cellular cGMP levels. Cardiovascular disease is…”
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Biphasic Coupling of Neuronal Nitric Oxide Synthase Phosphorylation to the NMDA Receptor Regulates AMPA Receptor Trafficking and Neuronal Cell Death by Rameau, Gerald A, Tukey, David S, Garcin-Hosfield, Elsa D, Titcombe, Roseann F, Misra, Charu, Khatri, Latika, Getzoff, Elizabeth D, Ziff, Edward B

“…Postsynaptic nitric oxide (NO) production affects synaptic plasticity and neuronal cell death. Ca2+ fluxes through the NMDA receptor (NMDAR) stimulate the…”
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Structure/function of the soluble guanylyl cyclase catalytic domain by Childers, Kenneth C., Garcin, Elsa D.

“…Soluble guanylyl cyclase (GC-1) is the primary receptor of nitric oxide (NO) in smooth muscle cells and maintains vascular function by inducing vasorelaxation…”
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A new paradigm for gaseous ligand selectivity of hemoproteins highlighted by soluble guanylate cyclase by Wu, Gang, Martin, Emil, Berka, Vladimir, Liu, Wen, Garcin, Elsa D., Tsai, Ah-Lim

“…Nitric oxide (NO), carbon monoxide (CO), and oxygen (O2) are important physiological messengers whose concentrations vary in a remarkable range, [NO] typically…”
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The Three Nitric-oxide Synthases Differ in Their Kinetics of Tetrahydrobiopterin Radical Formation, Heme-Dioxy Reduction, and Arginine Hydroxylation by Wei, Chin-Chuan, Wang, Zhi-Qiang, Durra, Deborah, Hemann, Craig, Hille, Russ, Garcin, Elsa D., Getzoff, Elizabeth D., Stuehr, Dennis J.

“…The nitric-oxide synthases (NOSs) make nitric oxide and citrulline from l-arginine. How the bound cofactor (6R)-tetrahydrobiopterin (H4B) participates in Arg…”
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Synergistic mutations in soluble guanylyl cyclase (sGC) reveal a key role for interfacial regions in the sGC activation mechanism by Childers, Kenneth C., Yao, Xin-Qiu, Giannakoulias, Sam, Amason, Joshua, Hamelberg, Donald, Garcin, Elsa D.

“…Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide (NO) and a central component of the NO-cGMP pathway, critical to cardiovascular function…”
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The sweet side of RNA regulation: glyceraldehyde-3-phosphate dehydrogenase as a noncanonical RNA-binding protein by White, Michael R., Garcin, Elsa D.

“…The glycolytic protein, glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH), has a vast array of extraglycolytic cellular functions, including interactions with…”
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A fusion of the Bacteroides fragilis ferrous iron import proteins reveals a role for FeoA in stabilizing GTP-bound FeoB by Sestok, Alex E., Brown, Janae B., Obi, Juliet O., O’Sullivan, Sean M., Garcin, Elsa D., Deredge, Daniel J., Smith, Aaron T.

“…Iron is an essential element for nearly all organisms, and under anoxic and/or reducing conditions, Fe2+ is the dominant form of iron available to bacteria…”
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Lys842 in Neuronal Nitric-oxide Synthase Enables the Autoinhibitory Insert to Antagonize Calmodulin Binding, Increase FMN Shielding, and Suppress Interflavin Electron Transfer by Guan, Zhi-Wen, Haque, Mohammad Mahfuzul, Wei, Chin-Chuan, Garcin, Elsa D., Getzoff, Elizabeth D., Stuehr, Dennis J.

“…Neuronal nitric-oxide synthase (nNOS) contains a unique autoinhibitory insert (AI) in its FMN subdomain that represses nNOS reductase activities and controls…”
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Surface Charge Interactions of the FMN Module Govern Catalysis by Nitric-oxide Synthase by Panda, Koustubh, Haque, Mohammad Mahfuzul, Garcin-Hosfield, Elsa D., Durra, Deborah, Getzoff, Elizabeth D., Stuehr, Dennis J.

“…The FMN module of nitric-oxide synthase (NOS) plays a pivotal role by transferring NADPH-derived electrons to the enzyme heme for use in oxygen activation. The…”
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Interfacial Residues Promote an Optimal Alignment of the Catalytic Center in Human Soluble Guanylate Cyclase: Heterodimerization Is Required but Not Sufficient for Activity by Seeger, Franziska, Quintyn, Royston, Tanimoto, Akiko, Williams, Gareth J, Tainer, John A, Wysocki, Vicki H, Garcin, Elsa D

“…Soluble guanylate cyclase (sGC) plays a central role in the cardiovascular system and is a drug target for the treatment of pulmonary hypertension. While the…”
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D-Glyceraldehyde-3-Phosphate Dehydrogenase Structure and Function by White, Michael R, Garcin, Elsa D

“…Aside from its well-established role in glycolysis, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been shown to possess many key functions in cells…”
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Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation by Sarkar, Anindya, Dai, Yue, Haque, Mohammad Mahfuzul, Seeger, Franziska, Ghosh, Arnab, Garcin, Elsa D, Montfort, William R, Hazen, Stanley L, Misra, Saurav, Stuehr, Dennis J

“…Heat shock protein 90 (hsp90) drives heme insertion into the β1 subunit of soluble guanylate cyclase (sGC) β1, which enables it to associate with a partner…”
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Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase by Garcin, Elsa D, Getzoff, Elizabeth D, Arvai, Andrew S, Rosenfeld, Robin J, Kroeger, Matt D, Crane, Brian R, Andersson, Gunilla, Andrews, Glen, Hamley, Peter J, Mallinder, Philip R, Nicholls, David J, St-Gallay, Stephen A, Tinker, Alan C, Gensmantel, Nigel P, Mete, Antonio, Cheshire, David R, Connolly, Stephen, Stuehr, Dennis J, Åberg, Anders, Wallace, Alan V, Tainer, John A

“…Nitric oxide synthase (NOS) enzymes synthesize nitric oxide, a signal for vasodilatation and neurotransmission at low concentrations and a defensive cytotoxin…”
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Small-angle X-ray scattering method to characterize molecular interactions: Proof of concept by Allec, Nicholas, Choi, Mina, Yesupriya, Nikhil, Szychowski, Brian, White, Michael R., Kann, Maricel G., Garcin, Elsa D., Daniel, Marie-Christine, Badano, Aldo

“…Characterizing biomolecular interactions is crucial to the understanding of biological processes. Existing characterization methods have low spatial…”
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Giant viruses of the Megavirinae subfamily possess biosynthetic pathways to produce rare bacterial-like sugars in a clade-specific manner by Notaro, Anna, Poirot, Olivier, Garcin, Elsa D, Nin, Sebastien, Molinaro, Antonio, Tonetti, Michela, De Castro, Cristina, Abergel, Chantal

“…Abstract The recent discovery that giant viruses encode proteins related to sugar synthesis and processing paved the way for the study of their glycosylation…”
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