Search Results - "Garcia Seisdedos, Hector"

Infinite Assembly of Folded Proteins in Evolution, Disease, and Engineering by Garcia‐Seisdedos, Hector, Villegas, José A., Levy, Emmanuel D.

“…Mutations and changes in a protein's environment are well known for their potential to induce misfolding and aggregation, including amyloid formation…”
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Symmetry Breaking in Homo-Oligomers: The Curious Case of Mega-Hemocyanin by Garcia Seisdedos, Hector, Steinberg, Avital, Levy, Emmanuel D.

“…Mega-hemocyanin is a 13.5 MDa oxygen transporter found in snails. It is built from three stacked rings involving ten subunits each. The cryo-EM structure of…”
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Mutant libraries reveal negative design shielding proteins from supramolecular self-assembly and relocalization in cells by Garcia Seisdedos, Hector, Levin, Tal, Shapira, Gal, Freud, Saskia, Levy, Emmanuel D

“…Understanding the molecular consequences of mutations in proteins is essential to map genotypes to phenotypes and interpret the increasing wealth of genomic…”
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Active site center redesign increases protein stability preserving catalysis in thioredoxin by Romero, Maria Luisa, Garcia Seisdedos, Hector, Ibarra‐Molero, Beatriz

“…The stabilization of natural proteins is a long‐standing desired goal in protein engineering. Optimizing the hydrophobicity of the protein core often results…”
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Infinite Ansammlungen gefalteter Proteine im Kontext von Evolution, Krankheiten und Proteinentwicklung by Garcia‐Seisdedos, Hector, Villegas, José A., Levy, Emmanuel D.

“…Mutationen und Veränderungen in der Umgebung eines Proteins sind bekannt dafür, potenziell Fehlfaltungen und Aggregation wie Amyloidbildung zu verursachen…”
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Probing the mutational interplay between primary and promiscuous protein functions: a computational-experimental approach by Garcia-Seisdedos, Hector, Ibarra-Molero, Beatriz, Sanchez-Ruiz, Jose M

“…Protein promiscuity is of considerable interest due its role in adaptive metabolic plasticity, its fundamental connection with molecular evolution and also…”
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How many ionizable groups can sit on a protein hydrophobic core? by Garcia-Seisdedos, Hector, Ibarra-Molero, Beatriz, Sanchez-Ruiz, Jose M.

“…Full or partial burial of ionizable groups in the hydrophobic interior of proteins underlies the large modulation in group properties (modified pK value, high…”
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Exploring Structural Determinants and Functional Aspects of Micron‐scale Protein Assemblies in Living Cells by Levin, Tal, Seisdedos, Hector Garcia, Empereur-Mot, Charly, Levy, Emmanuel

“…Proteins are increasingly often seen as forming micron‐scale assemblies in their folded state. Such assemblies include, for example, CTP synthase, Glutamine…”
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Not Going with the Flow: How Cells Adapt Internal Physics by Garcia-Seisdedos, Hector, Heidenreich, Meta, Levy, Emmanuel D.

“…Defining the principles underlying the organization of biomolecules within cells is a key challenge of current cell biology research. Persson et al. now…”
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Proteins evolve on the edge of supramolecular self-assembly by Garcia-Seisdedos, Hector, Empereur-Mot, Charly, Elad, Nadav, Levy, Emmanuel D.

“…Introducing a single ‘sticky’ (hydrophobic) amino acid by point mutation into symmetric protein complexes frequently triggers their association into…”
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Geometric description of self-interaction potential in symmetric protein complexes by Empereur-Mot, Charly, Garcia-Seisdedos, Hector, Elad, Nadav, Dey, Sucharita, Levy, Emmanuel D.

“…Proteins can self-associate with copies of themselves to form symmetric complexes called homomers. Homomers are widespread in all kingdoms of life and allow…”
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Proteins Evolve on the Edge of Supramolecular Self-Assembly by Garcia Seisdedos, Héctor

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Infinite Ansammlungen gefalteter Proteine im Kontext von Evolution, Krankheiten und Proteinentwicklung by Garcia‐Seisdedos, Hector, Villegas, José A., Levy, Emmanuel D.

“…Mutationen und Veränderungen in der Umgebung eines Proteins sind bekannt dafür, potenziell Fehlfaltungen und Aggregation wie Amyloidbildung zu verursachen…”
Get full text