Search Results - "Garcia‐Olivares, Jennie"

Huperzine A suppresses absence seizures in the genetic absence epilepsy rat from Strasbourg (GAERS) model of genetic generalized epilepsy with absence seizures by Casillas‐Espinosa, Pablo M., Garcia‐Olivares, Jennie, Li, Rui, Li, Crystal, Yu, Chungping, Formella, Andrea E., O'Brien, Terence J.

“…Objective We evaluated huperzine A treatment in the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) model of genetic generalized epilepsy (GGE) with…”
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Gating of human ClC-2 chloride channels and regulation by carboxy-terminal domains by Garcia‐Olivares, Jennie, Alekov, Alexi, Boroumand, Mohammad Reza, Begemann, Birgit, Hidalgo, Patricia, Fahlke, Christoph

“…Eukaryotic ClC channels are dimeric proteins with each subunit forming an individual protopore. Single protopores are gated by a fast gate, whereas the slow…”
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Structural Determinants of the Dopamine Transporter Regulation Mediated by G Proteins by Rojas, Genoveva, Orellana, Ivana, Rosales-Rojas, Roberto, García-Olivares, Jennie, Comer, Jeffrey, Vergara-Jaque, Ariela

“…Dopamine clearance in the brain is controlled by the dopamine transporter (DAT), a protein residing in the plasma membrane, which drives reuptake of…”
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The SUMO-Conjugase Ubc9 Prevents the Degradation of the Dopamine Transporter, Enhancing Its Cell Surface Level and Dopamine Uptake by Cartier, Etienne, Garcia-Olivares, Jennie, Janezic, Eric, Viana, Juan, Moore, Michael, Lin, Min Landon, Caplan, Jeffrey L, Torres, Gonzalo, Kim, Yong-Hwan

“…The dopamine transporter (DAT) is a plasma membrane protein responsible for the uptake of released dopamine back to the presynaptic terminal and ending…”
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Inhibition of dopamine transporter activity by G protein βγ subunits by Garcia-Olivares, Jennie, Torres-Salazar, Delany, Owens, William A, Baust, Tracy, Siderovski, David P, Amara, Susan G, Zhu, Jun, Daws, Lynette C, Torres, Gonzalo E

“…Uptake through the Dopamine Transporter (DAT) is the primary mechanism of terminating dopamine signaling within the brain, thus playing an essential role in…”
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Two novel CLCN2 mutations accelerating chloride channel deactivation are associated with idiopathic generalized epilepsy by Saint-Martin, Cécile, Gauvain, Grégory, Teodorescu, Georgeta, Gourfinkel-An, Isabelle, Fedirko, Estelle, Weber, Yvonne G, Maljevic, Snezana, Ernst, Jan-Peter, Garcia-Olivares, Jennie, Fahlke, Christoph, Nabbout, Rima, LeGuern, Eric, Lerche, Holger, Christophe Poncer, Jean, Depienne, Christel

“…Heterozygous mutations in the CLCN2 gene encoding the voltage-gated chloride channel CLC2 have been identified in patients with idiopathic generalized epilepsy…”
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The molecular chaperone Hsc70 interacts with the vesicular monoamine transporter‐2 by Requena, Daniela F., Parra, Leonardo A., Baust, Tracy B., Quiroz, Marisol, Leak, Rehana K., Garcia‐Olivares, Jennie, Torres, Gonzalo E.

“…Synaptic transmission depends on the efficient loading of transmitters into synaptic vesicles by vesicular neurotransmitter transporters. The vesicular…”
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Allosteric modulation of human dopamine transporter activity under conditions promoting its dimerization by Cheng, Mary Hongying, Garcia-Olivares, Jennie, Wasserman, Steven, DiPietro, Jennifer, Bahar, Ivet

“…The human dopamine (DA) transporter (hDAT) is a key regulator of neurotransmission and a target for antidepressants and addictive drugs. Despite the recent…”
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Viloxazine Increases Cortical Serotonin Without Inhibiting Serotonin Reuptake at Doses Used to Treat ADHD by Garcia-Olivares, Jennie, Yegla, Brittney, Zweibaum, David, Koch, Jennifer, Bymaster, Frank, Yu, ChungPing

“…Abstract Background Most FDA-approved ADHD treatments increase norepinephrine (NE) and dopamine (DA); however, our prior preclinical studies of the…”
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Characterization of Viloxazine Effects on Cortical Serotonin Neurotransmission at Doses Relevant for ADHD Treatment by Garcia-Olivares, Jennie, Yegla, Brittney, Earnest, Jami, Maletic, Vladimir, Yu, ChungPing

“…Abstract Introduction Most ADHD treatments are thought to be effective due to augmentation of dopamine (DA) and norepinephrine (NE). Our prior preclinical…”
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Viloxazine in the Management of CNS Disorders: A Historical Overview and Current Status by Findling, Robert L., Candler, Shawn A., Nasser, Azmi F., Schwabe, Stefan, Yu, Chungping, Garcia-Olivares, Jennie, O’Neal, Welton, Newcorn, Jeffrey H.

“…Viloxazine has a long history of clinical use in Europe as an antidepressant, and has recently been repurposed into an extended-release form for the treatment…”
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New Insights into the Mechanism of Action of Viloxazine: Serotonin and Norepinephrine Modulating Properties by Yu, Chungping, Garcia-Olivares, Jennie, Candler, Shawn, Schwabe, Stefan, Maletic, Vladimir

“…Viloxazine was historically described as a norepinephrine reuptake inhibitor (NRI). Since NRIs have previously demonstrated efficacy in attention…”
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Interaction between the dopamine transporter and the Gβγ subunits of the heterotrimeric G‐protein modifies transporter function and response to psychostimulants by Garcia‐Olivares, Jennie, Torres‐Salazar, Delany, Wasserman, Steven A., Hong, Conrad W., Amara, Susan G.

“…Monoaminergic neurotransmission (dopamine, serotonin, and norepinephrine) is altered in complex psychiatric conditions such as depression, attention‐deficit…”
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A Mutation in TM7 of Excitatory Amino Acid Transporters Disrupts the Substrate-Dependent Gating of the Intrinsic Anion Conductance and Drives the Channel into a Constitutively Open State by Torres Salazar, Delany, Garcia-Olivares, Jennie, Amara, Susan G.

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A Mutation in Transmembrane Domain 7 (TM7) of Excitatory Amino Acid Transporters Disrupts the Substrate-dependent Gating of the Intrinsic Anion Conductance and Drives the Channel into a Constitutively Open State by Torres-Salazar, Delany, Jiang, Jie, Divito, Christopher B., Garcia-Olivares, Jennie, Amara, Susan G.

“…In the mammalian central nervous system, excitatory amino acid transporters (EAATs) are responsible for the clearance of glutamate after synaptic release. This…”
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Emerging Evidence for a Direct Link between EAAT-Associated Anion Channels and Neurological Disorders by Gonzalez-Suarez, Aneysis D, Nash, Abigail I, Garcia-Olivares, Jennie, Torres-Salazar, Delany

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Insights into the Gating Mechanism of Excitatory Amino Acid Transporters-Associated Anion Channel by Torres-Salazar, Delany, Poblete, Horacio, Gonzalez-Suarez, Aneysis, Vergara-Jaque, Ariela, Garcia-Olivares, Jennie, Comer, Jeffrey, Amara, Susan G.

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The α1-β-Subunit Interaction That Modulates Calcium Channel Activity Is Reversible and Requires a Competent α-Interaction Domain by Hidalgo, Patricia, Gonzalez-Gutierrez, Giovanni, Garcia-Olivares, Jennie, Neely, Alan

“…High voltage-gated calcium channels consist of a pore-forming subunit (α1) and three nonhomologous subunits (α2/δ, β, and γ). Although it is well established…”
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Viloxazine Increases Extracellular Concentrations of Norepinephrine, Dopamine, and Serotonin in the Rat Prefrontal Cortex at Doses Relevant for the Treatment of Attention-Deficit/Hyperactivity Disorder by Garcia-Olivares, Jennie, Yegla, Brittney, Bymaster, Frank P, Earnest, Jami, Koch, Jennifer, Yu, Chungping, Rubin, Jonathan

“…Viloxazine ER (viloxazine extended-release capsules; Qelbree ), a nonstimulant attention-deficit/hyperactivity disorder (ADHD) treatment, has known activity as…”
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Folding of Active Calcium Channel β1b -Subunit by Size-exclusion Chromatography and Its Role on Channel Function by Neely, Alan, Garcia-Olivares, Jennie, Voswinkel, Stephan, Horstkott, Hannelore, Hidalgo, Patricia

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