Search Results - "Garcia‐Canovas, Francisco"

Study of tyrosine and dopa enantiomers as tyrosinase substrates initiating l‐ and d‐melanogenesis pathways by Fernandez‐Julia, Pedro J., Tudela‐Serrano, Jose, Garcia‐Molina, Francisco, Garcia‐Canovas, Francisco, Garcia‐Jimenez, Antonia, Munoz‐Munoz, Jose L.

“…Tyrosinase starts melanogenesis and determines its course, catalyzing the oxidation by molecular oxygen of tyrosine to dopa, and that of dopa to dopaquinone…”
Get full text

Action of ellagic acid on the melanin biosynthesis pathway by Ortiz-Ruiz, Carmen Vanessa, Berna, Jose, Tudela, Jose, Varon, Ramon, Garcia-Canovas, Francisco

“…Highlights • Ellagic acid is not an inhibitor but an alternative substrate of tyrosinase. • The Michaelis and catalytic constants of ellagic acid are 138 μM…”
Get full text

Suicide inactivation of the diphenolase and monophenolase activities of tyrosinase by Muñoz‐Muñoz, Jose Luis, Garcia‐Molina, Francisco, Varon, Ramon, Garcia‐Ruíz, Pedro A., Tudela, Jose, Garcia‐Cánovas, Francisco, Rodríguez‐López, Jose Neptuno

“…The suicide inactivation mechanism of tyrosinase acting on its phenolic substrates has been studied. Kinetic analysis of the proposed mechanism during the…”
Get full text

Quantification of the Antioxidant Capacity of Different Molecules and Their Kinetic Antioxidant Efficiencies by Munoz-Munoz, Jose Luis, Garcia-Molina, Francisco, Varon, Ramon, Tudela, Jose, García-Cánovas, Francisco, Rodriguez-Lopez, Jose Neptuno

“…A kinetic method has been developed to determine the antioxidant capacity of a variety of molecules. In this method, named the enzymatic kinetic method, the…”
Get full text

Kinetic characterization of substrate‐analogous inhibitors of tyrosinase by Ortiz‐Ruiz, Carmen Vanessa, Maria‐Solano, Miguel Angel, Garcia‐Molina, Maria Del Mar, Varon, Ramon, Tudela, Jose, Tomas, Virginia, Garcia‐Canovas, Francisco

“…The development of effective tyrosinase inhibitors has become increasingly important in the cosmetic, medicinal, and agricultural industries for application as…”
Get full text

Catalysis and inactivation of tyrosinase in its action on hydroxyhydroquinone by del Mar Garcia‐Molina, Maria, Muñoz‐Muñoz, Jose Luis, Berna, Jose, García‐Ruiz, Pedro Antonio, Rodriguez‐Lopez, Jose Neptuno, Garcia‐Canovas, Francisco

“…Hydroxyhydroquinone (HHQ) was characterized kinetically as a tyrosinase substrate. A kinetic mechanism is proposed, in which HHQ is considered as a monophenol…”
Get full text

Action of tyrosinase on alpha and beta-arbutin: A kinetic study by Garcia-Jimenez, Antonio, Teruel-Puche, Jose Antonio, Berna, Jose, Rodriguez-Lopez, José Neptuno, Tudela, Jose, Garcia-Canovas, Francisco

“…The known derivatives from hydroquinone, α and β-arbutin, are used as depigmenting agents. In this work, we demonstrate that the oxy form of tyrosinase…”
Get full text

Considerations on the action of polyphenoloxidase on 4-hydroxy-cinnamic acid. Molecular docking simulation by García Molina, Pablo, Antonio Teruel Puche, Jose, Luis Muñoz Muñoz, Jose, Neptuno Rodriguez Lopez, Jose, García Canovas, Francisco, García Molina, Francisco

Get full text

The Relationship between the IC50 Values and the Apparent Inhibition Constant in the Study of Inhibitors of Tyrosinase Diphenolase Activity Helps Confirm the Mechanism of Inhibition by Garcia-Molina, Pablo, Garcia-Molina, Francisco, Teruel-Puche, Jose Antonio, Rodriguez-Lopez, Jose Neptuno, Garcia-Canovas, Francisco, Muñoz-Muñoz, Jose Luis

“…Tyrosinase is the enzyme involved in melanization and is also responsible for the browning of fruits and vegetables. Control of its activity can be carried out…”
Get full text

Catalysis and inhibition of tyrosinase in the presence of cinnamic acid and some of its derivatives by Garcia-Jimenez, Antonio, García-Molina, Francisco, Teruel-Puche, Jose A., Saura-Sanmartin, Adrian, Garcia-Ruiz, Pedro A., Ortiz-Lopez, Antonio, Rodríguez-López, Jose N., Garcia-Canovas, Francisco, Munoz-Munoz, Jose

“…The kinetic action of tyrosinase on l-tyrosine and l-Dopa as substrates in the presence of cinnamic acid and some of its derivatives has been characterized…”
Get full text

Structural and kinetic considerations on the catalysis of deoxyarbutin by tyrosinase by Garcia-Jimenez, Antonio, Teruel-Puche, Jose Antonio, Garcia-Ruiz, Pedro Antonio, Saura-Sanmartin, Adrian, Berna, Jose, Garcia-Canovas, Francisco, Rodriguez-Lopez, José Neptuno

“…Deoxyarbutin, a potent inhibitor of tyrosinase, could act as substrate of the enzyme. Oxytyrosinase is able to hydroxylate deoxyarbutin and finishes the…”
Get full text

4‐n‐butylresorcinol, a depigmenting agent used in cosmetics, reacts with tyrosinase by Garcia‐Jimenez, Antonio, Teruel‐Puche, Jose Antonio, Ortiz‐Ruiz, Carmen Vanessa, Berna, Jose, Tudela, Jose, Garcia‐Canovas, Francisco

“…4‐n‐Butylresorcinol (BR) is considered the most potent inhibitor of tyrosinase, which is why it is used in cosmetics as a depigmenting agent. However, this…”
Get full text

Kinetic characterization of oxyresveratrol as a tyrosinase substrate by Ortiz‐Ruiz, Carmen Vanessa, Ballesta de los Santos, Manuel, Berna, Jose, Fenoll, Jose, Garcia‐Ruiz, Pedro Antonio, Tudela, Jose, Garcia‐Canovas, Francisco

“…Oxyresveratrol is a stilbenoid described as a powerful inhibitor of tyrosinase and proposed as skin‐whitening and anti‐browning agent. However, the enzyme is…”
Get full text

Enzymatic oxidation of oleuropein and 3‐hydroxytyrosol by laccase, peroxidase, and tyrosinase by Manzano‐Nicolas, Jesus, Taboada‐Rodriguez, Amaury, Teruel‐Puche, Jose Antonio, Marin‐Iniesta, Fulgencio, Garcia‐Molina, Francisco, Garcia‐Canovas, Francisco, Tudela‐Serrano, Jose, Munoz‐Munoz, Jose

“…The oxidation of oleuropein and 3‐hydroxytyrosol by oxidases laccase, tyrosinase, and peroxidase has been studied. The use of a spectrophotometric method and…”
Get full text

Action of Tyrosinase on Ortho-Substituted Phenols: Possible Influence on Browning and Melanogenesis by Garcia-Molina, Maria del Mar, Muñoz-Muñoz, Jose Luis, Garcia-Molina, Francisco, García-Ruiz, Pedro Antonio, Garcia-Canovas, Francisco

“…The action of tyrosinase on ortho-substituted monophenols (thymol, carvacrol, guaiacol, butylated hydroxyanisole, eugenol, and isoeugenol) was studied. These…”
Get full text

Continuous Spectrophotometric Method for Determining Monophenolase and Diphenolase Activities of Pear Polyphenoloxidase by ESPÍN, JUAN CARLOS, MORALES, MERCEDES, VARÓN, RAMÓN, TUDELA, JOSÉ, GARCÍA-CÁNOVAS, FRANCISCO

“…ABSTRACT A continuous spectrophotometric method was based on the coupling reaction between 3‐methyl‐2‐benzothiazolinone hydrazone (MBTH) and the quinone…”
Get full text

Deuterium isotope effect on the suicide inactivation of tyrosinase in its action on o‐diphenols by Muñoz‐Muñoz, Jose Luis, del Mar García‐Molina, María, Garcia‐Molina, Francisco, Garcia‐Ruiz, Pedro Antonio, Garcia‐Sevilla, Francisco, Rodriguez‐Lopez, Jose N., Garcia‐Canovas, Francisco

“…A solvent deuterium isotope effect on the inactivation suicide of tyrosinase in its action on o‐diphenols (catechol, 4‐methylcatechol, and…”
Get full text

Suicide inactivation of tyrosinase in its action on tetrahydropterines by Muñoz-Muñoz, Jose Luis, Garcia-Molina, Francisco, Arribas, Enrique, Garcia-Ruíz, Pedro Antonio, Tudela, Jose, Garcia-Cánovas, Francisco, Rodríguez-López, Jose Neptuno

“…Tetrahydrobiopterin (BH(4)), methyl-tetrahydropterin (MBH(4)) and dimethyl-tetrahydropterin (DMBH(4)) are oxidized by tyrosinase in a process during which the…”
Get more information

Kinetic cooperativity of tyrosinase. A general mechanism by Muñoz-Muñoz, Jose Luis, Garcia-Molina, Francisco, Varon, Ramón, Tudela, Jose, Garcia-Cánovas, Francisco, Rodríguez-López, Jose N

“…Tyrosinase shows kinetic cooperativity in its action on o-diphenols, but not when it acts on monophenols, confirming that the slow step is the hydroxylation of…”
Get full text

Indirect inactivation of tyrosinase in its action on tyrosine by Muñoz-Muñoz, Jose Luis, Garcia-Molina, Francisco, Acosta-Motos, Jose Ramon, Arribas, Enrique, Garcia-Ruíz, Pedro Antonio, Tudela, Jose, Garcia-Cánovas, Francisco, Rodríguez-López, Jose Neptuno

“…Under aerobic conditions, tyrosinase is inactivated by dopa as a result of suicide inactivation, and, under anaerobic conditions, as a result of irreversible…”
Get full text