Search Results - "Garcia, Marc"

The Disproportionate Impact of COVID-19 on Older Latino Mortality: The Rapidly Diminishing Latino Paradox by Sáenz, Rogelio, Garcia, Marc A

“…This brief report aims to highlight stark mortality disparities among older Latinos that result from the novel coronavirus disease (COVID-19) pandemic. We use…”
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The Color of COVID-19: Structural Racism and the Disproportionate Impact of the Pandemic on Older Black and Latinx Adults by Garcia, Marc A, Homan, Patricia A, García, Catherine, Brown, Tyson H

“…The aim of this evidence-based theoretically informed article was to provide an overview of how and why the COVID-19 outbreak is particularly detrimental for…”
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Exacerbating Inequalities: Social Networks, Racial/Ethnic Disparities, and the COVID-19 Pandemic in the United States by Gauthier, Gertrude R, Smith, Jeffrey A, García, Catherine, Garcia, Marc A, Thomas, Patricia A

“…The disruption and contraction of older adults' social networks are among the less discussed consequences of the COVID-19 pandemic. Our objective was to…”
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The Unexplored Importance of Fleeting Chiral Intermediates in Enzyme-Catalyzed Reactions by Reetz, Manfred T, Garcia-Borràs, Marc

“…Decades of extensive research efforts by biochemists, organic chemists, and protein engineers have led to an understanding of the basic mechanisms of…”
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Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants by Li, Aitao, Acevedo‐Rocha, Carlos G., D'Amore, Lorenzo, Chen, Jinfeng, Peng, Yaqin, Garcia‐Borràs, Marc, Gao, Chenghua, Zhu, Jinmei, Rickerby, Harry, Osuna, Sílvia, Zhou, Jiahai, Reetz, Manfred T.

“…Steroidal C7β alcohols and their respective esters have shown significant promise as neuroprotective and anti‐inflammatory agents to treat chronic neuronal…”
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Selective Biocatalytic N‐Methylation of Unsaturated Heterocycles by Ospina, Felipe, Schülke, Kai H., Soler, Jordi, Klein, Alina, Prosenc, Benjamin, Garcia‐Borràs, Marc, Hammer, Stephan C.

“…Methods for regioselective N‐methylation and ‐alkylation of unsaturated heterocycles with “off the shelf” reagents are highly sought‐after. This reaction could…”
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Chemometrics characterization of The Llobregat river dissolved organic matter by Marín-García, Marc, Tauler, Romà

“…The potential use of multivariate chemometric methods for the investigation of the dissolved organic matter (DOM) sources in surface river waters monitored by…”
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Computational tools for the evaluation of laboratory-engineered biocatalysts by Romero-Rivera, Adrian, Garcia-Borràs, Marc, Osuna, Sílvia

“…Biocatalysis is based on the application of natural catalysts for new purposes, for which enzymes were not designed. Although the first examples of…”
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Role of Conformational Dynamics in the Evolution of Retro-Aldolase Activity by Romero-Rivera, Adrian, Garcia-Borràs, Marc, Osuna, Sílvia

“…Enzymes exist as ensembles of conformations that are important for function. Tuning these populations of conformational states through mutation enables…”
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UV-Vis absorption spectrophotometry and LC-DAD-MS-ESI(+)-ESI(-) coupled to chemometrics analysis of the monitoring of sulfamethoxazole degradation by chlorination, photodegradation, and chlorination/photodegradation by Queral-Beltran, Aina, Marín-García, Marc, Lacorte, Silvia, Tauler, Romà

“…Sulfamethoxazole (SMX) is one of the most widely used antibiotics worldwide and has been detected at high concentrations in wastewater treatment plant…”
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Protoglobin‐Catalyzed Formation of cis‐Trifluoromethyl‐Substituted Cyclopropanes by Carbene Transfer by Schaus, Lucas, Das, Anuvab, Knight, Anders M., Jimenez‐Osés, Gonzalo, Houk, K. N., Garcia‐Borràs, Marc, Arnold, Frances H., Huang, Xiongyi

“…Trifluoromethyl‐substituted cyclopropanes (CF3‐CPAs) constitute an important class of compounds for drug discovery. While several methods have been developed…”
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Reversing the Enantioselectivity of Enzymatic Carbene N−H Insertion Through Mechanism‐Guided Protein Engineering by Calvó‐Tusell, Carla, Liu, Zhen, Chen, Kai, Arnold, Frances H., Garcia‐Borràs, Marc

“…We report a computationally driven approach to access enantiodivergent enzymatic carbene N−H insertions catalyzed by P411 enzymes. Computational modeling was…”
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Racial/Ethnic and Nativity Differences in Cognitive Life Expectancies Among Older Adults in the United States by Garcia, Marc A, Downer, Brian, Chiu, Chi-Tsun, Saenz, Joseph L, Rote, Sunshine, Wong, Rebeca

“…Abstract Background and Objectives To document racial/ethnic and nativity differences by gender in cognitive life expectancies among older adults in the United…”
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Engineered P450 Atom-Transfer Radical Cyclases are Bifunctional Biocatalysts: Reaction Mechanism and Origin of Enantioselectivity by Fu, Yue, Chen, Heyu, Fu, Wenzhen, Garcia-Borràs, Marc, Yang, Yang, Liu, Peng

“…New-to-nature radical biocatalysis has recently emerged as a powerful strategy to tame fleeting open-shell intermediates for stereoselective transformations…”
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Molecular Basis for Chemoselectivity Control in Oxidations of Internal Aryl‐Alkenes Catalyzed by Laboratory Evolved P450s by Soler, Jordi, Gergel, Sebastian, Hammer, Stephan C., Garcia‐Borràs, Marc

“…P450 enzymes naturally perform selective hydroxylations and epoxidations of unfunctionalized hydrocarbon substrates, among other reactions. The adaptation of…”
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Enzymatic Control over Reactive Intermediates Enables Direct Oxidation of Alkenes to Carbonyls by a P450 Iron-Oxo Species by Soler, Jordi, Gergel, Sebastian, Klaus, Cindy, Hammer, Stephan C., Garcia-Borràs, Marc

“…The aerobic oxidation of alkenes to carbonyls is an important and challenging transformation in synthesis. Recently, a new P450-based enzyme (aMOx) has been…”
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Selective Enzymatic Oxidation of Silanes to Silanols by Bähr, Susanne, Brinkmann‐Chen, Sabine, Garcia‐Borràs, Marc, Roberts, John M., Katsoulis, Dimitris E., Houk, K. N., Arnold, Frances H.

“…Compared to the biological world's rich chemistry for functionalizing carbon, enzymatic transformations of the heavier homologue silicon are rare. We report…”
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Cognition and Context: Rural–Urban Differences in Cognitive Aging Among Older Mexican Adults by Saenz, Joseph L., Downer, Brian, Garcia, Marc A., Wong, Rebeca

“…Objective: To describe differences in cognitive functioning across rural and urban areas among older Mexican adults. Method: We include respondents aged 50+ in…”
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Coupling of spectrometric, chromatographic, and chemometric analysis in the investigation of the photodegradation of sulfamethoxazole by Marín-García, Marc, De Luca, Michele, Ragno, Gaetano, Tauler, Romà

“…A workflow is proposed for the study of the photodegradation process of the sulfamethoxazole (SMX) based on the combination of different experimental…”
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Efficient Transferase Engineering for SAM Analog Synthesis from Iodoalkanes by Schülke, Kai H., Fröse, Jana S., Klein, Alina, Garcia‐Borràs, Marc, Hammer, Stephan C.

“…S‐Adenosyl‐l‐methionine (SAM) is an important cosubstrate in various biochemical processes, including selective methyl transfer reactions. Simple methods for…”
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