Integrated analysis of clinical, bioelectrical and functional variables in newly diagnosed lung cancer adult patients: pilot study

BackgroundMany variables have been studied in cancer patients. Nevertheless, an study that analyzes simultaneously physical, functional and biological variables in they from clinical, physical and statistical points of views is not reported in the literature. The aim of this study is to propose an i...

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Published in:	Translational medicine communications Vol. 7; no. 1; pp. 1 - 16
Main Authors:	Regüeiferos, Justa Carmen Columbié, Luna, Taira Teresa Batista, Brooks, Soraida Cándida Acosta, Rodriguez, Maylet Planas, Matamoros, Larisa Zamora, Rodríguez, Beatríz Legrá, Fernández, Arnolis Poll, Bello, José Luis García, Pedrón, Arquímedes Montoya, González, Maraelys Morales, Garcia, Julio Cesar Núñez, Fonseca, Esmirna Cascaret, Cabrales, Luis Enrique Bergues
Format:	Journal Article
Language:	English
Published:	London BioMed Central 23-08-2022 BMC
Subjects:	Association coefficient of eta Bioelectrical impedance analysis Body mass index Epidermal growth factor Gender Hospitals Lung cancer Medical prognosis Medical research Newly diagnosed lung cancer adult patients Patients Pilot projects Principal component analysis Principal components analysis Pulmonology Quality of life Spearman’s rho correlation coefficient Cuba Germany
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Summary:	BackgroundMany variables have been studied in cancer patients. Nevertheless, an study that analyzes simultaneously physical, functional and biological variables in they from clinical, physical and statistical points of views is not reported in the literature. The aim of this study is to propose an integrated analysis of clinical, bioelectrical and functional variables in newly diagnosed lung cancer adult patients for the integral evaluation and possible prognostic of them.MethodsThis Pilot study was retrospective and cross-sectional and 23 patients aged 53–82 years participated in it. The electrical resistance and capacitive electrical reactance were measured with the Bodystat Quadscan® 4000 analyzer. The electrical impedance modulus and the phase angle were calculated. The serum concentrations of epidermal growth factor, CYFRA21-1 and CA 72–4 were quantified. Correlations/associations among variables and the principal component analysis were suggested.ResultsThe majority of patients had tumor markers, electrical resistance and the phase angle in their respective normal ranges. The capacitive electrical resistance was below its normal range. Minimum, low and moderate grades of linear correlation/association prevailed among studied variables. The principal components I and II were interpreted as prognosis and body energetic reserve of the patient, respectively.ConclusionsIt is concluded that the clinical, bioelectrical and functional variables allow the integral analysis and possible prognosis of newly diagnosed lung cancer adult patients. The decrease of the capacitive electrical reactance is the most influence to the loss of the body energetic reserve that leads to alterations of the overall health, tiredness and decrease of weight and body mass index of these patients.
ISSN:	2396-832X 2396-832X
DOI:	10.1186/s41231-022-00127-3