Search Results - "Garcia, J. G. N."

Differential and opposing effects of imatinib on LPS- and ventilator-induced lung injury by Letsiou, E, Rizzo, A N, Sammani, S, Naureckas, P, Jacobson, J R, Garcia, J G N, Dudek, S M

“…Endothelial dysfunction underlies the pathophysiology of vascular disorders such as acute lung injury (ALI) syndromes. Recent work has identified the Abl…”
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FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl by WANG, L, CHIANG, E. T, SIMMONS, J. T, GARCIA, J. G. N, DUDEK, S. M

“…Strategies to improve pulmonary endothelial barrier function are needed to reverse the devastating effects of vascular leak in acute respiratory distress…”
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The Significant Role of c-Abl Kinase in Barrier Altering Agonists-mediated Cytoskeletal Biomechanics by Wang, X., Wang, L., Garcia, J. G. N., Dudek, S. M., Shekhawat, G. S., Dravid, V. P.

“…Exploration of human pulmonary artery endothelial cell (EC) as a prototypical biomechanical system has important pathophysiologic relevance because this cell…”
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Suppression of endotoxin-induced inflammation by taxol by Mirzapoiazova, T, Kolosova, I. A, Moreno, L, Sammani, S, Garcia, J. G. N, Verin, A. D

“…The pathogenesis of acute lung injury includes transendothelial diapedesis of leukocytes into lung tissues and disruption of endothelial/epithelial barriers…”
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Amifostine reduces lung vascular permeability via suppression of inflammatory signalling by Fu, P, Birukova, A. A, Xing, J, Sammani, S, Murley, J. S, Garcia, J. G. N, Grdina, D. J, Birukov, K. G

“…Despite an encouraging outcome of antioxidant therapy in animal models of acute lung injury, effective antioxidant agents for clinical application remain to be…”
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Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis by Man, M, Close, S L, Shaw, A D, Bernard, G R, Douglas, I S, Kaner, R J, Payen, D, Vincent, J-L, Fossceco, S, Janes, J M, Leishman, A G, O'Brien, L, Williams, M D, Garcia, J G N

“…Management of severe sepsis, an acute illness with high morbidity and mortality, suffers from the lack of effective biomarkers and largely empirical…”
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Synthetic analogs of FTY720 [2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] differentially regulate pulmonary vascular permeability in vivo and in vitro by Camp, S M, Bittman, R, Chiang, E T, Moreno-Vinasco, L, Mirzapoiazova, T, Sammani, S, Lu, X, Sun, C, Harbeck, M, Roe, M, Natarajan, V, Garcia, J G N, Dudek, S M

“…Novel therapies are needed to address the vascular endothelial cell (EC) barrier disruption that occurs in inflammatory diseases such as acute lung injury…”
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Novel therapies for microvascular permeability in sepsis by Jacobson, J R, Garcia, J G N

“…Sepsis is characterized physiologically by an aberrant systemic inflammatory response and microvascular dysfunction. While appropriate antibiotics and…”
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Imatinib Alters Agonists-mediated Cytoskeletal Biomechanics in Lung Endothelium by Wang, X., Bleher, R., Wang, L., Garcia, J. G. N., Dudek, S. M., Shekhawat, G. S., Dravid, V. P.

“…The endothelium serves as a size-selective barrier and tightly controls the fluid exchange from the circulation to the surrounding tissues. In this study, a…”
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Differential elastic responses to barrier-altering agonists in two types of human lung endothelium by Viswanathan, P., Ephstein, Y., Garcia, J.G.N., Cho, M., Dudek, S.M.

“…Vascular integrity is primarily determined by endothelial cell (EC) cytoskeletal structure that is differentially regulated by various stimuli. In this study,…”
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Methylnaltrexone inhibits opiate and VEGF-induced angiogenesis: Role of receptor transactivation by Singleton, P.A., Lingen, M.W., Fekete, M.J., Garcia, J.G.N., Moss, J.

“…Angiogenesis or the formation of new blood vessels is important in the growth and metastatic potential of various cancers. Therefore, agents that inhibit…”
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Vascular endothelial cell activation and permeability responses to thrombin by Garcia, J G, Pavalko, F M, Patterson, C E

“…The serine protease, thrombin, evokes numerous endothelial cell responses which regulate hemostasis, thrombosis and vessel wall pathophysiology. One such…”
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Molecular mechanisms of thrombin-induced endothelial cell permeability by Bogatcheva, N V, Garcia, J G N, Verin, A D

“…Confluent endothelium serves as a selective barrier between the vascular space of blood vessels and underlying tissues. Compromised barrier function of the…”
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Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families by Barnes, K C, Grant, A V, Baltadzhieva, D, Zhang, S, Berg, T, Shao, L, Zambelli-Weiner, A, Anderson, W, Nelsen, A, Pillai, S, Yarnall, D P, Dienger, K, Ingersoll, R G, Scott, A F, Fallin, M D, Mathias, R A, Beaty, T H, Garcia, J G N, Wills-Karp, M

“…Proinflammatory and immunoregulatory products from C3 play a major role in phagocytosis, respiratory burst, and airways inflammation. C3 is critical in…”
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Cytoskeletal rearrangement and caspase activation in sphingosine 1-phosphate-induced lung capillary tube formation by Linz-McGillem, L A, Moitra, J, Garcia, J G N

“…Angiogenesis is a multistep process involving the endothelial cell (EC) cytoskeleton in migration, proliferation, and barrier stabilization. Although precise…”
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Methylnaltrexone Potentiates Inhibition of VEGF-Induced Angiogenesis by 5-Fluorouracil (5-FU) and Bevacizumab: 9AP4-8 by Moss, J, Singleton, P A, Garcia, J G. N

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Regulation of thrombin-induced endothelial cell activation by bacterial toxins by Patterson, C E, Garcia, J G

“…It has previously been shown that thrombin effects on endothelial cells can be mediated via G-proteins, which couple the thrombin receptor to several key…”
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Rituximab in the treatment of refractory pulmonary sarcoidosis by Sweiss, Nadera J, Lower, Elyse E, Mirsaeidi, Mehdi, Dudek, Steven, Garcia, Joe G N, Perkins, David, Finn, Patricia W, Baughman, Robert P

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A97 MOLECULAR TARGETS AND PATHWAYS IN AGING: Nampt Mediates Age-Associated Pro-Fibrotic Myofibroblast Phenotypes And Persistent Fibrosis by Hecker, L, Wang, T, Garcia, J G N

“…Human lung fibroblasts at low and high population doublings (control and senescent, respectively), as a model of cellular aging; and IPF and age-matched adult…”
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33 BIOINFORMATIC CLASS DISCOVERY OF POTENTIAL BIOMARKERS IN VENTILATOR-ASSOCIATED LUNG INJURY by Ma, S.-F., Grigoryev, D. N., Easley, R. B., Ye, S. Q., Simon, B. A., Garcia, J. G N.

“…RationaleThe unilateral (one lung injured and the contralateral lung intact) model of ventilator-associated lung injury (VALI) allows us to utilize uninjured…”
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