Search Results - "Garcia, George"

Elucidation of Key Interactions between VirF and the virB Promoter in Shigella flexneri Using E. coli MarA- and GadX-Based Homology Models and In Vitro Analysis of the DNA-Binding Domains of VirF and MarA by Ragazzone, Nicholas J, Dow, Garrett T, Garcia, George A

“…Infection with , the organism responsible for the diarrheal disease shigellosis, leads to approximately 200,000 deaths globally annually. Virulence of this…”
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Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis by Molodtsov, Vadim, Scharf, Nathan T., Stefan, Maxwell A., Garcia, George A., Murakami, Katsuhiko S.

“…Summary Since 1967, Rifampin (RMP, a Rifamycin) has been used as a first line antibiotic treatment for tuberculosis (TB), and it remains the cornerstone of…”
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Elucidation of the DNA-Binding Activity of VirF from Shigella flexneri for the icsA and rnaG Promoters and Characterization of the N-Terminal Domain To Identify Residues Crucial for Dimerization by Dow, Garrett T, Young, Anna M, Garcia, George A

“…A novel approach to treat the highly virulent and infectious enteric pathogen Shigella flexneri, with the potential for reduced resistance development, is to…”
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Greenness, air pollution, and mortality risk: A U.S. cohort study of cancer patients and survivors by Coleman, Carver J., Yeager, Ray A., Riggs, Daniel W., Coleman, Nathan C., Garcia, George R., Bhatnagar, Aruni, Pope, C. Arden

“…•This study evaluated greenness and air pollution on mortality risk of cancer patients and survivors in the U.S.•Greenness, as measured by NDVI, was associated…”
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Shape of BMI–Mortality Risk Associations: Reverse Causality and Heterogeneity in a Representative Cohort of US Adults by Garcia, George R., Coleman, Nathan C., Pond, Zachari A., Pope, C. Arden

“…Objective This study examines BMI–mortality associations and evaluates strategies intended to limit reverse causality. Heterogeneity in BMI–mortality risk…”
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Designing health impact functions to assess marginal changes in outdoor fine particulate matter by Burnett, Richard T., Spadaro, Joseph V., Garcia, George R., Pope, C. Arden

“…Estimating health benefits from improvements in ambient air quality requires the characterization of the magnitude and shape of the association between…”
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Source of the Fitness Defect in Rifamycin-Resistant Mycobacterium tuberculosis RNA Polymerase and the Mechanism of Compensation by Mutations in the β' Subunit by Stefan, Maxwell A, Ugur, Fatima S, Garcia, George A

“…is a critical threat to human health due to the increased prevalence of rifampin resistance (RMP ). Fitness defects have been observed in RMP mutants with…”
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Mechanism of Action and Initial, In Vitro SAR of an Inhibitor of the Shigella flexneri Virulence Regulator VirF by Emanuele, Anthony A, Garcia, George A

“…Shigella spp. are among the main causative agents of acute diarrheal illness and claim more than 1 million lives per year worldwide. There are multiple…”
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Cardiopulmonary Mortality and Fine Particulate Air Pollution by Species and Source in a National U.S. Cohort by Pond, Zachari A., Hernandez, Carlos S., Adams, Peter J., Pandis, Spyros N., Garcia, George R., Robinson, Allen L., Marshall, Julian D., Burnett, Richard, Skyllakou, Ksakousti, Garcia Rivera, Pablo, Karnezi, Eleni, Coleman, Carver J., Pope, C. Arden

“…The purpose of this study was to estimate cardiopulmonary mortality associations for long-term exposure to PM2.5 species and sources (i.e., components) within…”
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High-throughput screening to discover inhibitors of the CarD·RNA polymerase protein–protein interaction in Mycobacterium tuberculosis by Stefan, Maxwell A., Velazquez, Glory M., Garcia, George A.

“…Multidrug-resistant Mycobacterium tuberculosis (MDR-TB) accounts for 3.7% of new cases of TB annually worldwide and is a major threat to global public health…”
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Theobroma cacao L. cultivar CCN 51: a comprehensive review on origin, genetics, sensory properties, production dynamics, and physiological aspects by Jaimez, Ramon E, Barragan, Luigy, Fernández-Niño, Miguel, Wessjohann, Ludger A, Cedeño-Garcia, George, Sotomayor Cantos, Ignacio, Arteaga, Francisco

“…Many decades of improvement in cacao have aided to obtain cultivars with characteristics of tolerance to diseases, adaptability to different edaphoclimatic…”
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A Proposal to Use ROUTE/DASH in the Advanced ISDB-T by Oliveira, George Henrique Maranhao Garcia de, de Melo Valeira, Gustavo, Akamine, Cristiano

“…In Brazil, the Television (TV) 3.0 project has been underway since 2020 and is currently in its third phase. The aim of this project is to study, test and…”
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Simulated redistricting plans for the analysis and evaluation of redistricting in the United States by McCartan, Cory, Kenny, Christopher T., Simko, Tyler, Garcia, George, Wang, Kevin, Wu, Melissa, Kuriwaki, Shiro, Imai, Kosuke

“…This article introduces the 50 stateSimulations , a collection of simulated congressional districting plans and underlying code developed by the…”
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Synthesis of azide congeners of preQ1 as potential substrates for tRNA guanine transglycosylase by Brooks, Allen F., Garcia, George A., Showalter, Hollis D.

“…PreQ1 (2) is a precursor of queuine (1) that in eubacteria is incorporated into transfer RNA (tRNA) by tRNA guanine transglycosylase (TGT) before being further…”
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Advanced surgical skills for exposure in trauma (ASSET): the first 25 courses by Bowyer, Mark W., MD, FACS, Kuhls, Deborah A., MD, FACS, Haskin, Danielle, MSW, Sallee, Richard A., BS, Henry, Sharon M., MD, FACS, Garcia, George D., MD, FACS, Luchette, Frederick A., MD, FACS

“…Abstract Background The Advanced Surgical Skills for Exposure in Trauma (ASSET) course was developed to address limited experience of residents and practicing…”
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Response to Viewpoint – Point/Counterpoint: Should a Pharmacy Dean be a Pharmacist? by Garcia, George A.

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Rifamycins – Obstacles and opportunities by Aristoff, Paul A, Garcia, George A, Kirchhoff, Paul D, Hollis Showalter, H.D

“…Summary With nearly one-third of the global population infected by Mycobacterium tuberculosis , TB remains a major cause of death (1.7 million in 2006). TB is…”
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Metal‐HisTag coordination for remote loading of very small quantities of biomacromolecules into PLGA microspheres by Albert, Jason, Chang, Rae Sung, Garcia, George A., Schwendeman, Steven P.

“…Challenges to discovery and preclinical development of long‐acting release systems for protein therapeutics include protein instability, use of organic…”
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Confirmation of a second natural preQ1 aptamer class in Streptococcaceae bacteria by Meyer, Michelle M, Roth, Adam, Chervin, Stephanie M, Garcia, George A, Breaker, Ronald R

“…Bioinformatics searches of eubacterial genomes have yielded many riboswitch candidates where the identity of the ligand is not immediately obvious on…”
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Advanced Surgical Skills for Exposure in Trauma (ASSET) course improves military surgeon confidence by Saberi, Rebecca A, Parker, Graham B, Mohsin, Noreen, Gilna, Gareth P, Cioci, Alessia C, Urrechaga, Eva M, Buzzelli, Mark D, Schulman, Carl I, Proctor, Kenneth G, Garcia, George D

“…Active duty military surgeons often have limited trauma surgery experience prior to deployment. Consequently, military-civilian training programs have been…”
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