Search Results - "Garcia, Cybele"

Dengue virus targets RBM10 deregulating host cell splicing and innate immune response by Pozzi, Berta, Bragado, Laureano, Mammi, Pablo, Torti, María Florencia, Gaioli, Nicolás, Gebhard, Leopoldo G, García Solá, Martín E, Vaz-Drago, Rita, Iglesias, Néstor G, García, Cybele C, Gamarnik, Andrea V, Srebrow, Anabella

“…Abstract RNA-seq experiments previously performed by our laboratories showed enrichment in intronic sequences and alterations in alternative splicing in…”
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Membraneless Organelles and Condensates Orchestrate Innate Immunity Against Viruses by Boccaccio, Graciela Lidia, Thomas, María Gabriela, García, Cybele Carina

“…[Display omitted] •The immune activation of a number of pattern recognition receptors upon virus infection involves their oligomerization and the formation of…”
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The Aryl Hydrocarbon Receptor as a Modulator of Anti-viral Immunity by Torti, Maria Florencia, Giovannoni, Federico, Quintana, Francisco Javier, García, Cybele Carina

“…The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, which interacts with a wide range of organic molecules of endogenous and…”
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AHR signaling is induced by infection with coronaviruses by Giovannoni, Federico, Li, Zhaorong, Remes-Lenicov, Federico, Dávola, María E., Elizalde, Mercedes, Paletta, Ana, Ashkar, Ali A., Mossman, Karen L., Dugour, Andrea V., Figueroa, Juan M., Barquero, Andrea A., Ceballos, Ana, Garcia, Cybele C., Quintana, Francisco J.

“…Coronavirus infection in humans is usually associated to respiratory tract illnesses, ranging in severity from mild to life-threatening respiratory failure…”
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AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication by Booth, Laurence, Roberts, Jane L., Ecroyd, Heath, Tritsch, Sarah R., Bavari, Sina, Reid, St. Patrick, Proniuk, Stefan, Zukiwski, Alexander, Jacob, Abraham, Sepúlveda, Claudia S., Giovannoni, Federico, García, Cybele C., Damonte, Elsa, González-Gallego, Javier, Tuñón, María J., Dent, Paul

“…We have recently demonstrated that AR‐12 (OSU‐03012) reduces the function and ATPase activities of multiple HSP90 and HSP70 family chaperones. Combined knock…”
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Sulfated xylogalactofucans from Spatoglossum asperum: Production, structural features and antiviral activity by Mukherjee, Shuvam, Chemen, Mathias E., Pal, Saikat, Piccini, Luana E., Jana, Subrata, Damonte, Elsa B., Ray, Bimalendu, Garcia, Cybele C., Ray, Sayani

“…In cultured cells, herpes simplex virus (HSV) infectivity is successfully inhibited by sulfated polysaccharides. Herein, we utilized an amalgamated…”
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AHR is a Zika virus host factor and a candidate target for antiviral therapy by Giovannoni, Federico, Bosch, Irene, Polonio, Carolina Manganeli, Torti, María F., Wheeler, Michael A., Li, Zhaorong, Romorini, Leonardo, Rodriguez Varela, María S., Rothhammer, Veit, Barroso, Andreia, Tjon, Emily C., Sanmarco, Liliana M., Takenaka, Maisa C., Modaresi, Seyed Mohamad Sadegh, Gutiérrez-Vázquez, Cristina, Zanluqui, Nágela Ghabdan, dos Santos, Nilton Barreto, Munhoz, Carolina Demarchi, Wang, Zhongyan, Damonte, Elsa B., Sherr, David, Gehrke, Lee, Peron, Jean Pierre Schatzmann, Garcia, Cybele C., Quintana, Francisco J.

“…Zika virus (ZIKV) is a flavivirus linked to multiple birth defects including microcephaly, known as congenital ZIKV syndrome. The identification of host…”
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De novo design approaches targeting an envelope protein pocket to identify small molecules against dengue virus by Leal, Emilse S., Adler, Natalia S., Fernández, Gabriela A., Gebhard, Leopoldo G., Battini, Leandro, Aucar, Maria G., Videla, Mariela, Monge, María Eugenia, Hernández de los Ríos, Alejandro, Acosta Dávila, John Alejandro, Morell, María L., Cordo, Sandra M., García, Cybele C., Gamarnik, Andrea V., Cavasotto, Claudio N., Bollini, Mariela

“…Dengue fever is a mosquito-borne viral disease that has become a major public health concern worldwide. This disease presents with a wide range of clinical…”
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Chemically modified galactans of Grateloupia indica: From production to in vitro antiviral activity by Ali, Imran, Chemen, Mathias E., Piccini, Luana E., Mukherjee, Shuvam, Jana, Subrata, Damonte, Elsa B., Ray, Bimalendu, Garcia, Cybele C., Ray, Sayani

“…Herpes simplex viruses (HSVs) have an affinity for heparan sulfate proteoglycans on cell surfaces, which is a determinant for virus entry. Herein, several…”
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Dengue Non-structural Protein 5 Polymerase Complexes With Promyelocytic Leukemia Protein (PML) Isoforms III and IV to Disrupt PML-Nuclear Bodies in Infected Cells by Giovannoni, Federico, Ladelfa, María Fatima, Monte, Martin, Jans, David A, Hemmerich, Peter, García, Cybele

“…Dengue virus (DENV) threatens almost 70% of the world's population, with no therapeutic currently available. The severe, potentially lethal forms of DENV…”
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Zika virus infection of first trimester trophoblast cells affects cell migration, metabolism and immune homeostasis control by Vota, Daiana, Torti, María, Paparini, Daniel, Giovannoni, Federico, Merech, Fátima, Hauk, Vanesa, Calo, Guillermina, Ramhorst, Rosanna, Garcia, Cybele, Pérez Leirós, Claudia

“…Zika virus (ZIKV) re‐emerged after circulating almost undetected for many years and the last spread in 2015 was the major outbreak reported. ZIKV infection was…”
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Broad-Spectrum Antiviral Effect of Cannabidiol Against Enveloped and Nonenveloped Viruses by Marquez, Agostina B, Vicente, Josefina, Castro, Eliana, Vota, Daiana, Rodríguez-Varela, María S, Lanza Castronuovo, Priscila A, Fuentes, Giselle M, Parise, Alejandro R, Romorini, Leonardo, Alvarez, Diego E, Bueno, Carlos A, Ramirez, Cristina L, Alaimo, Agustina, García, Cybele C

“…Cannabidiol (CBD), the main non-psychoactive cannabinoid of the plant, is a powerful antioxidant compound that in recent years has increased interest due to…”
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Antiviral activity of an N-allyl acridone against dengue virus by Mazzucco, María B, Talarico, Laura B, Vatansever, Sezen, Carro, Ana C, Fascio, Mirta L, D'Accorso, Norma B, García, Cybele C, Damonte, Elsa B

“…Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespread causative agent of a human viral disease transmitted by mosquitoes…”
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Synthesis and Antibacterial Activity of Difluoromethyl Cinnamoyl Amides by Martínez, Mario David, Riva, Diego Ariel, Garcia, Cybele, Durán, Fernando Javier, Burton, Gerardo

“…Series of novel amides of isoferulic acid, where the phenolic hydroxyl was replaced by a difluoromethyl group, were synthesized and their in vitro…”
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Author Correction: AHR is a Zika virus host factor and a candidate target for antiviral therapy by Giovannoni, Federico, Bosch, Irene, Polonio, Carolina Manganeli, Torti, María F., Wheeler, Michael A., Li, Zhaorong, Romorini, Leonardo, Rodriguez Varela, María S., Rothhammer, Veit, Barroso, Andreia, Tjon, Emily C., Sanmarco, Liliana M., Takenaka, Maisa C., Modaresi, Seyed Mohamad Sadegh, Gutiérrez-Vázquez, Cristina, Zanluqui, Nágela Ghabdan, dos Santos, Nilton Barreto, Munhoz, Carolina Demarchi, Wang, Zhongyan, Damonte, Elsa B., Sherr, David, Gehrke, Lee, Peron, Jean Pierre Schatzmann, Garcia, Cybele C., Quintana, Francisco J.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Altered functioning of the HPA axis in depressed postpartum women by de Rezende, Marcos Gonçalves, Garcia-Leal, Cybele, de Figueiredo, Felipe Pinheiro, Cavalli, Ricardo de Carvalho, Spanghero, Maristela Schaufelberger, Barbieri, Marco Antonio, Bettiol, Heloisa, de Castro, Margaret, Del-Ben, Cristina Marta

“…Abstract Background The present study aimed to evaluate the relationship between the functioning of the hypothalamic–pituitary–adrenal (HPA) axis and major…”
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Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever by Zapata, Juan C., Pauza, C. David, Djavani, Mahmoud M., Rodas, Juan D., Moshkoff, Dmitry, Bryant, Joseph, Ateh, Eugene, Garcia, Cybele, Lukashevich, Igor S., Salvato, Maria S.

“…► History of LCMV infections of primates (from mice to monkeys and man). ► Comparison of outcomes in murine and primate infections. ► Description of findings…”
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Experimental public speaking: Contributions to the understanding of the serotonergic modulation of fear by GARCIA-LEAL, Cybele, GRAEFF, Frederico Guilherme, DEL-BEN, Cristina Marta

“…Public speaking is widely used as a model of experimental fear and anxiety. This review aimed to evaluate the effects of pharmacological challenges on public…”
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Promyelocytic leukemia protein is a restriction factor for Junín virus independently of Z matrix protein by Giovannoni, Federico, Vazquez, Cecilia A., Thomas, Pablo, Gómez, Ricardo M., García, Cybele C.

“…The New World (NW) mammarenavirus Junín (JUNV) is the etiological agent of Argentine hemorrhagic fever, a human endemic disease of Argentina. Promyelocytic…”
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Antiviral drug discovery: Pyrimidine entry inhibitors for Zika and dengue viruses by Gallo, Facundo N., Marquez, Agostina B., Fidalgo, Daniela M., Dana, Alejandro, Dellarole, Mariano, García, Cybele C., Bollini, Mariela

“…Vector-borne diseases, constituting over 17 % of infectious diseases, are caused by parasites, viruses, and bacteria, and their prevalence is shaped by…”
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