Search Results - "Garcia, Celia R. S."

Synthesis and antiplasmodial activity of betulinic acid and ursolic acid analogues by Innocente, Adrine M, Silva, Gloria N S, Cruz, Laura Nogueira, Moraes, Miriam S, Nakabashi, Myna, Sonnet, Pascal, Gosmann, Grace, Garcia, Célia R S, Gnoatto, Simone C B

“…More than 40% of the World population is at risk of contracting malaria, which affects primarily poor populations in tropical and subtropical areas…”
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Structurally Related Auxin and Melatonin Tryptophan‐Derivatives and their Roles in Arabidopsis thaliana and in the Human Malaria Parasite Plasmodium falciparum by Koyama, Fernanda C, Carvalho, Thais L. G, Alves, Eduardo, da Silva, Henrique B, Azevedo, Mauro F, Hemerly, Adriana S, Garcia, Célia R. S

“…Indole compounds are involved in a range of functions in many organisms. In the human malaria parasite Plasmodium falciparum, melatonin and other tryptophan…”
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Release of Plasmodium sporozoites requires proteins with histone-fold dimerization domains by Currà, Chiara, Gessmann, Renate, Pace, Tomasino, Picci, Leonardo, Peruzzi, Giulia, Varamogianni-Mamatsi, Vassiliki, Spanos, Lefteris, Garcia, Célia R. S., Spaccapelo, Roberta, Ponzi, Marta, Siden-Kiamos, Inga

“…The sporozoite, the stage of the malaria parasite transmitted by the mosquito, first develops for ∼2 weeks in an oocyst. Rupture of the oocyst capsule is…”
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Melatonin-induced temporal up-regulation of gene expression related to ubiquitin/proteasome system (UPS) in the human malaria parasite Plasmodium falciparum by Koyama, Fernanda C, Azevedo, Mauro F, Budu, Alexandre, Chakrabarti, Debopam, Garcia, Célia R S

“…There is an increasing understanding that melatonin and the ubiquitin/ proteasome system (UPS) interact to regulate multiple cellular functions…”
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Ribifolin, an Orbitide from Jatropha ribifolia, and Its Potential Antimalarial Activity by Pinto, Meri Emili F, Batista, João M, Koehbach, Johannes, Gaur, Pratibha, Sharma, Abhinay, Nakabashi, Myna, Cilli, Eduardo Maffud, Giesel, Guilherme M, Verli, Hugo, Gruber, Christian W, Blanch, Ewan W, Tavares, Joseam F, Silva, Marcelo S. da, Garcia, Celia R. S, Bolzani, Vanderlan S

“…A new orbitide named ribifolin was isolated and characterized from Jatropha ribifolia using mass spectrometry, NMR spectroscopy, quantitative amino acid…”
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Investigation of antimalarial activity, cytotoxicity and action mechanism of piperazine derivatives of betulinic acid by Silva, Gloria N. S., Schuck, Desirée C., Cruz, Laura N., Moraes, Miriam S., Nakabashi, Myna, Gosmann, Grace, Garcia, Célia R. S., Gnoatto, Simone C. B.

“…Objectives To semisynthesise piperazine derivatives of betulinic acid to evaluate antimalarial activity, cytotoxicity and action mechanism. Methods The new…”
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Human malarial parasite, Plasmodium falciparum, displays capacitative calcium entry: 2-aminoethyl diphenylborinate blocks the signal transduction pathway of melatonin action on the P. falciparum cell cycle by Beraldo, Flávio H., Mikoshiba, Katsuhiko, Garcia, Célia R. S.

“…:  The malarial parasite senses the environment to modulate its own cycle. Knowledge of the mechanisms for regulation signaling processes at the invasion,…”
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Melatonin triggers PKA activation in the rodent malaria parasite Plasmodium chabaudi by Gazarini, Marcos L., Beraldo, Flávio H., Almeida, Fabiana M., Bootman, Martin, Da Silva, Aline M., Garcia, Célia R. S.

“…:  Calcium (Ca2+) is a critical regulator of many aspects of the Plasmodium reproductive cycle. In particular, intra‐erythrocyte Plasmodium parasites respond…”
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A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin by Singh, Maneesh Kumar, Bonnell, Victoria Ann, Tojal Da Silva, Israel, Santiago, Verônica Feijoli, Moraes, Miriam Santos, Adderley, Jack, Doerig, Christian, Palmisano, Giuseppe, Llinas, Manuel, Garcia, Celia R S

“…Dynamic control of gene expression is critical for blood stage development of malaria parasites. Here, we used multi-omic analyses to investigate…”
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Melatonin signaling and its modulation of PfNF-YB transcription factor expression in Plasmodium falciparum by Lima, Wânia Rezende, Holder, Anthony A, Garcia, Célia R S

“…Malaria is one of the most severe tropical infectious diseases. More than 220 million people around the world have a clinical malaria infection and about one…”
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Regulation of multidrug resistance‐associated protein 2 by calcium signaling in mouse liver by Cruz, Laura N., Guerra, Mateus T., Kruglov, Emma, Mennone, Albert, Garcia, Celia R. S., Chen, Ju, Nathanson, Michael H.

“…Multidrug resistance associated protein 2 (Mrp2) is a canalicular transporter responsible for organic anion secretion into bile. Mrp2 activity is regulated by…”
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Ubiquitin proteasome system and the atypical kinase PfPK7 are involved in melatonin signaling in Plasmodium falciparum by Koyama, Fernanda C., Ribeiro, Ramira Y., Garcia, Julio L., Azevedo, Mauro F., Chakrabarti, Debopam, Garcia, Célia R. S.

“…:  We previously reported that melatonin modulates the Plasmodium falciparum erythrocytic cycle by increasing schizont stage population as well as diminishing…”
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Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents by Deda, Daiana K, Iglesias, Bernardo A, Alves, Eduardo, Araki, Koiti, Garcia, Celia R S

“…Porphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and luminescence properties demonstrating high potential in the treatment of…”
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The PfNF-YB transcription factor is a downstream target of melatonin and cAMP signalling in the human malaria parasite Plasmodium falciparum by Lima, Wânia R., Moraes, Miriam, Alves, Eduardo, Azevedo, Mauro F., Passos, Dario O., Garcia, Célia R. S.

“…:  Plasmodium falciparum causes the most severe form of malaria and is responsible for the majority of deaths worldwide. The mechanism of cell cycle control…”
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Intracellular Ca2+ Signaling in Protozoan Parasites: An Overview with a Focus on Mitochondria by Scarpelli, Pedro H., Pecenin, Mateus F., Garcia, Celia R. S.

“…Ca2+ signaling has been involved in controling critical cellular functions such as activation of proteases, cell death, and cell cycle control. The…”
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Biological evaluation of hydroxynaphthoquinones as anti-malarials by Schuck, Desiree C, Ferreira, Sabrina B, Cruz, Laura N, da Rocha, David R, Moraes, Miriam S, Nakabashi, Myna, Rosenthal, Philip J, Ferreira, Vitor F, Garcia, Celia R S

“…The hydroxynaphthoquinones have been extensively investigated over the past 50 years for their anti-malarial activity. One member of this class, atovaquone, is…”
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Evidence of G-Protein-Coupled Receptors (GPCR) in the Parasitic Protozoa Plasmodium falciparum -Sensing the Host Environment and Coupling within Its Molecular Signaling Toolkit by Pereira, Pedro H S, Garcia, Celia R S

“…Throughout evolution, the need for single-celled organisms to associate and form a single cluster of cells has had several evolutionary advantages. In complex,…”
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Two series of new semisynthetic triterpene derivatives: differences in anti-malarial activity, cytotoxicity and mechanism of action by da Silva, Gloria N S, Maria, Nicole R G, Schuck, Desirée C, Cruz, Laura N, de Moraes, Miriam S, Nakabashi, Myna, Graebin, Cedric, Gosmann, Grace, Garcia, Célia R S, Gnoatto, Simone C B

“…The discovery and development of anti-malarial compounds of plant origin and semisynthetic derivatives thereof, such as quinine (QN) and chloroquine (CQ), has…”
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A nuclear protein, PfMORC confers melatonin dependent synchrony of the human malaria parasite P. falciparum in the asexual stage by Singh, Maneesh K., Tessarin-Almeida, Giulliana, Dias, Barbara K. M., Pereira, Pedro Scarpellli, Costa, Fahyme, Przyborski, Jude M., Garcia, Celia R. S.

“…The host hormone melatonin is known to modulate the asexual cell-cycle of the human malaria parasite Plasmodium falciparum and the kinase PfPK7 is fundamental…”
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The Knockout for G Protein-Coupled Receptor-Like PfSR25 Increases the Susceptibility of Malaria Parasites to the Antimalarials Lumefantrine and Piperaquine but Not to Medicine for Malaria Venture Compounds by Santos, Benedito M, Dias, Bárbara K M, Nakabashi, Myna, Garcia, Celia R S

“…Previously we have reported that the G protein-coupled receptor (GPCR)-like PfSR25 in is a potassium (K ) sensor linked to intracellular calcium signaling and…”
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