Search Results - "Garcia, Camila C. M."
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DNA Adduct Formation in the Lungs and Brain of Rats Exposed to Low Concentrations of [13C2]‑Acetaldehyde
Published in Chemical research in toxicology (21-05-2018)“…Air pollution is a major environmental risk for human health. Acetaldehyde is present in tobacco smoke and vehicle exhaust. In this study, we show that…”
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Photorepair of Either CPD or 6-4PP DNA Lesions in Basal Keratinocytes Attenuates Ultraviolet-Induced Skin Effects in Nucleotide Excision Repair Deficient Mice
Published in Frontiers in immunology (29-03-2022)“…Ultraviolet (UV) radiation is one of the most genotoxic, universal agents present in the environment. UVB (280-315 nm) radiation directly damages DNA,…”
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Sustained kidney biochemical derangement in treated experimental diabetes: a clue to metabolic memory
Published in Scientific reports (12-01-2017)“…The occurrence of biochemical alterations that last for a long period of time in diabetic individuals even after adequate handling of glycemia is an intriguing…”
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Brazilian Ironstone Plant Communities as Reservoirs of Culturable Bacteria With Diverse Biotechnological Potential
Published in Frontiers in microbiology (23-07-2018)“…Extensive mineral extractivism in the Brazilian Iron Quadrangle (IQ) region has destroyed large areas of land, decimating plant species, and their associated…”
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Flow Injection Amperometric Detection of 2‘-Deoxyguanosine at a Ruthenium Oxide Hexacyanoferrate Modified Electrode
Published in Analytical chemistry (Washington) (15-07-2007)“…A ruthenium oxide hexacyanoferrate (RuOHCF) modified electrode was developed. Hydrodynamic voltammetry was employed to demonstrate the remarkable…”
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Detection of DNA Adduct Formation in Rat Lungs by a Micro-HPLC/MS/MS Approach
Published in Methods in molecular biology (Clifton, N.J.) (2021)“…Aldehydes are abundantly present in tobacco smoke and in urban air pollution and are endogenously generated as products of the lipid peroxidation process…”
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XPD/ERCC2 mutations interfere in cellular responses to oxidative stress
Published in Mutagenesis (19-12-2019)“…Nucleotide excision repair (NER) is a conserved, flexible mechanism responsible for the removal of bulky, helix-distorting DNA lesions, like ultraviolet damage…”
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trans,trans-2,4-decadienal induces mitochondrial dysfunction and oxidative stress
Published in Journal of bioenergetics and biomembranes (01-04-2008)“…Lipid peroxidation produces a large number of reactive aldehydes as secondary products. We have previously shown that the reaction of cytochrome c with…”
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Long-term intermittent feeding, but not caloric restriction, leads to redox imbalance, insulin receptor nitration, and glucose intolerance
Published in Free radical biology & medicine (01-10-2011)“…Calorie restriction is a dietary intervention known to improve redox state, glucose tolerance, and animal life span. Other interventions have been adopted as…”
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Elevated α-methyl-γ-hydroxy-1,N2-propano-2'-deoxyguanosine levels in urinary samples from individuals exposed to urban air pollution
Published in Chemical research in toxicology (18-11-2013)“…Acetaldehyde and crotonaldehyde are genotoxic aldehydes present in tobacco smoke and vehicle exhaust. The reaction of these aldehydes with 2'-deoxyguanosine in…”
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Increased SOD1 association with chromatin, DNA damage, p53 activation, and apoptosis in a cellular model of SOD1-linked ALS
Published in Biochimica et biophysica acta (01-05-2010)“…Mutations in the gene encoding cytosolic Cu,Zn-superoxide dismutase (SOD1) have been linked to familial amyotrophic lateral sclerosis (FALS). However the…”
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Ultrasensitive simultaneous quantification of 1,N2-etheno-2'-deoxyguanosine and 1,N2-propano-2'-deoxyguanosine in DNA by an online liquid chromatography-electrospray tandem mass spectrometry assay
Published in Chemical research in toxicology (19-07-2010)“…Exocyclic DNA adducts produced by exogenous and endogenous compounds are emerging as potential tools to study a variety of human diseases and air pollution…”
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Oxidative and alkylating damage in DNA
Published in Mutation research (01-11-2003)“…Modification of cellular DNA upon exposure to reactive oxygen and nitrogen species is the likely initial event involved in the induction of the mutagenic and…”
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Journal Article Conference Proceeding -
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Elevated α‑Methyl-γ-hydroxy-1,N 2 ‑propano-2′-deoxyguanosine Levels in Urinary Samples from Individuals Exposed to Urban Air Pollution
Published in Chemical research in toxicology (18-11-2013)“…Acetaldehyde and crotonaldehyde are genotoxic aldehydes present in tobacco smoke and vehicle exhaust. The reaction of these aldehydes with 2′-deoxyguanosine in…”
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Ultrasensitive Simultaneous Quantification of 1,N 2-Etheno-2′-deoxyguanosine and 1,N 2-Propano-2′-deoxyguanosine in DNA by an Online Liquid Chromatography−Electrospray Tandem Mass Spectrometry Assay
Published in Chemical research in toxicology (19-07-2010)“…Exocyclic DNA adducts produced by exogenous and endogenous compounds are emerging as potential tools to study a variety of human diseases and air pollution…”
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Journal Article -
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Development of an On-Line Liquid Chromatography-Electrospray Tandem Mass Spectrometry Assay to Quantitatively Determine 1,N 2-Etheno-2‘-deoxyguanosine in DNA
Published in Chemical research in toxicology (01-10-2002)“…A method involving on-line reversed-phase high-performance liquid chromatography with electrospray tandem mass spectrometry detection has been developed for…”
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Quantification of DNA adducts in lungs, liver and brain of rats exposed to acetaldehyde
Published in Free radical biology & medicine (01-10-2014)“…Air pollution is a major risk for human health. Acetaldehyde is an environmental pollutant present in tobacco smoke, vehicle exhaust and several food products…”
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Journal Article -
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Elevated alpha -Methyl- gamma -hydroxy-1,N super(2)-prop ano-2'-deoxyguanosine Levels in Urinary Samples from Individuals Exposed to Urban Air Pollution
Published in Chemical research in toxicology (18-11-2013)“…Acetaldehyde and crotonaldehyde are genotoxic aldehydes present in tobacco smoke and vehicle exhaust. The reaction of these aldehydes with 2'-deoxyguanosine in…”
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Journal Article -
20
Development of an on-line liquid chromatography-electrospray tandem mass spectrometry assay to quantitatively determine 1,N(2)-etheno-2'-deoxyguanosine in DNA
Published in Chemical research in toxicology (01-10-2002)“…A method involving on-line reversed-phase high-performance liquid chromatography with electrospray tandem mass spectrometry detection has been developed for…”
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