Search Results - "Garcia, Angel"

High-resolution reversible folding of hyperstable RNA tetraloops using molecular dynamics simulations by Chen, Alan A., García, Angel E.

“…We report the de novo folding of three hyperstable RNA tetraloops to 1–3 Å rmsd from their experimentally determined structures using molecular dynamics…”
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What do we know about university academics' mental health? A systematic literature review by Urbina‐Garcia, Angel

“…There has been a growing interest in the negative influence that the environment of higher education institutions has on the mental health of academics. The…”
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Characterization of Aβ Monomers through the Convergence of Ensemble Properties among Simulations with Multiple Force Fields by Rosenman, David J, Wang, Chunyu, García, Angel E

“…Amyloid β (Aβ) monomers represent a base state in the pathways of aggregation that result in the fibrils and oligomers implicated in the pathogenesis of…”
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The Plasma Membrane as a Competitive Inhibitor and Positive Allosteric Modulator of KRas4B Signaling by Neale, Chris, García, Angel E.

“…Mutant Ras proteins are important drivers of human cancers, yet no approved drugs act directly on this difficult target. Over the last decade, the idea has…”
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Cosolvent effects on protein stability by Canchi, Deepak R, García, Angel E

“…Proteins are marginally stable, and the folding/unfolding equilibrium of proteins in aqueous solution can easily be altered by the addition of small organic…”
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Methionine 170 is an Environmentally Sensitive Membrane Anchor in the Disordered HVR of K‑Ras4B by Neale, Chris, García, Angel E

“…Ras protein colocalization at the plasma membrane is implicated in the activation of signaling cascades that promote cell growth, survival, and motility…”
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Power systems with high renewable energy sources: A review of inertia and frequency control strategies over time by Fernández-Guillamón, Ana, Gómez-Lázaro, Emilio, Muljadi, Eduard, Molina-García, Ángel

“…Traditionally, inertia in power systems has been determined by considering all the rotating masses directly connected to the grid. During the last decade, the…”
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Water Determines the Structure and Dynamics of Proteins by Bellissent-Funel, Marie-Claire, Hassanali, Ali, Havenith, Martina, Henchman, Richard, Pohl, Peter, Sterpone, Fabio, van der Spoel, David, Xu, Yao, Garcia, Angel E

“…Water is an essential participant in the stability, structure, dynamics, and function of proteins and other biomolecules. Thermodynamically, changes in the…”
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Analysis of focus measure operators for shape-from-focus by Pertuz, Said, Puig, Domenec, Garcia, Miguel Angel

“…Shape-from-focus (SFF) has widely been studied in computer vision as a passive depth recovery and 3D reconstruction method. One of the main stages in SFF is…”
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Decentralized Demand-Side Contribution to Primary Frequency Control by Molina-García, Angel, Bouffard, François, Kirschen, Daniel S

“…Frequency in large power systems is usually controlled by adjusting the production of generating units in response to changes in the load. As the amount of…”
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Trajectory PHD and CPHD Filters by Garcia-Fernandez, Angel F., Svensson, Lennart

“…This paper presents the probability hypothesis density filter (PHD) and the cardinality PHD (CPHD) filter for sets of trajectories, which are referred to as…”
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Presence or Absence of Ras Dimerization Shows Distinct Kinetic Signature in Ras-Raf Interaction by Sarkar, Sumantra, García, Angel E.

“…Initiations of cell signaling pathways often occur through the formation of multiprotein complexes that form through protein-protein interactions. Therefore,…”
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Insight on Tafel slopes from a microkinetic analysis of aqueous electrocatalysis for energy conversion by Shinagawa, Tatsuya, Garcia-Esparza, Angel T., Takanabe, Kazuhiro

“…Microkinetic analyses of aqueous electrochemistry involving gaseous H 2 or O 2 , i.e., hydrogen evolution reaction (HER), hydrogen oxidation reaction (HOR),…”
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A Metric on the Space of Finite Sets of Trajectories for Evaluation of Multi-Target Tracking Algorithms by Garcia-Fernandez, Angel F., Rahmathullah, Abu Sajana, Svensson, Lennart

“…In this article, we propose a metric on the space of finite sets of trajectories for assessing multi-target tracking algorithms in a mathematically sound way…”
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Millisecond molecular dynamics simulations of KRas-dimer formation and interfaces by Ngo, Van A., Garcia, Angel E.

“…Ras dimers have been proposed as building blocks for initiating the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK)…”
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Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease by Lastres-Becker, Isabel, García-Yagüe, Angel J, Scannevin, Robert H, Casarejos, María J, Kügler, Sebastian, Rábano, Alberto, Cuadrado, Antonio

“…This preclinical study was aimed at determining whether pharmacological targeting of transcription factor NRF2, a master controller of many homeostatic genes,…”
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Characterization of Heparin’s Conformational Ensemble by Molecular Dynamics Simulations and Nuclear Magnetic Resonance Spectroscopy by Janke, J. Joel, Yu, Yanlei, Pomin, Vitor H, Zhao, Jing, Wang, Chunyu, Linhardt, Robert J, García, Angel E

“…Heparin is a highly charged, polysulfated polysaccharide and serves as an anticoagulant. Heparin binds to multiple proteins throughout the body, suggesting a…”
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Influence of water-protein hydrogen bonding on the stability of Trp-cage miniprotein. A comparison between the TIP3P and TIP4P-Ew water models by Paschek, Dietmar, Day, Ryan, García, Angel E

“…We report extensive replica exchange molecular dynamics (REMD) simulations on the folding/unfolding equilibrium of Trp-cage miniprotein using the Amber ff99SB…”
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Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations by Ye, Libin, Neale, Chris, Sljoka, Adnan, Lyda, Brent, Pichugin, Dmitry, Tsuchimura, Nobuyuki, Larda, Sacha T., Pomès, Régis, García, Angel E., Ernst, Oliver P., Sunahara, Roger K., Prosser, R. Scott

“…Cations play key roles in regulating G-protein-coupled receptors (GPCRs), although their mechanisms are poorly understood. Here, 19 F NMR is used to delineate…”
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Atomistic Simulations of Thermal Unfolding by Garcia, Angel E

“…This tutorial will provide a practical overview of the use of atomistic simulations to study thermal unfolding of biomolecules, in particular small proteins…”
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