Histopathological and immunohistochemical characteristics of malignant adenomyoepithelioma in a cat: case report

ABSTRACT The malignant adenomyoepithelioma is a rare mammary tumor in women and uncommon in cats with only one report in this species. In this case report, the histopathological and immunohistochemical characteristics of six cases of malignant adenomyopithelioma in the feline mammary gland are descr...

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Bibliographic Details
Published in:	Arquivo brasileiro de medicina veterinária e zootecnia Vol. 73; no. 6; pp. 1351 - 1356
Main Authors:	Nunes, M.M., Garcia, A.P.V., Nakagaki, K.Y.R., Cassali, G.D.
Format:	Journal Article
Language:	English
Published:	Universidade Federal de Minas Gerais, Escola de Veterinária 01-12-2021 Universidade Federal de Minas Gerais
Subjects:	cat diagnosis malignant adenomyoepithelioma VETERINARY SCIENCES malignant adenomyoepithelioma diagnosis diagnóstico adenomioepitelioma maligno cat gata
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Summary:	ABSTRACT The malignant adenomyoepithelioma is a rare mammary tumor in women and uncommon in cats with only one report in this species. In this case report, the histopathological and immunohistochemical characteristics of six cases of malignant adenomyopithelioma in the feline mammary gland are described. Microscopic evaluation of tumors showed dense cellular neoplastic proliferation, composed of malignant myoepithelial and epithelial cells, formed by varied arrangements and presenting papillary, tubular and solid nest proliferation. Immunohistochemistry was performed for markers Ki67, Cox-2, RE, RP, p63 and HER-2. All cases were positive for p63, confirming the myoepithelial nature of neoplastic cells. The diagnosis of malignant adenomyopithelioma was made possible through the association between histopathological characteristics and immunohistochemical results. RESUMO O adenomioepitelioma maligno é uma neoplasia mamária rara em mulheres e incomum em gatas, possuindo apenas uma descrição nessa espécie. Neste relato de caso, são descritas as características histopatológicas e imuno-histoquímicas de seis casos de adenomioepitelioma maligno na glândula mamária felina. A avaliação microscópica dos tumores demonstrou proliferação neoplásica densamente celular, composta por células mioepiteliais e epiteliais malignas dispostas em padrão papilar, tubular e ninhos sólidos. Foi realizada técnica de imuno-histoquímica para os marcadores Ki67, Cox-2, RE, RP, p63 e HER-2. Todos os casos foram positivos para p63, confirmando a natureza mioepitelial das células neoplásicas. O diagnóstico de adenomioepitelioma maligno foi possível por meio da associação entre as características histopatológicas e os resultados de imuno-histoquímica.
ISSN:	0102-0935 1678-4162 1678-4162
DOI:	10.1590/1678-4162-12312