Search Results - "Garcia, A Joseph"

Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells by Chen, Rui, Xu, Min, Nagati, Jason, Garcia, Joseph A

“…Survival of cancer cells in the harsh tumor microenvironment, characterized by oxygen and glucose deprivation, requires rapid initiation of cytoprotective…”
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The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response by Puente, Bao N., Kimura, Wataru, Muralidhar, Shalini A., Moon, Jesung, Amatruda, James F., Phelps, Kate L., Grinsfelder, David, Rothermel, Beverly A., Chen, Rui, Garcia, Joseph A., Santos, Celio X., Thet, SuWannee, Mori, Eiichiro, Kinter, Michael T., Rindler, Paul M., Zacchigna, Serena, Mukherjee, Shibani, Chen, David J., Mahmoud, Ahmed I., Giacca, Mauro, Rabinovitch, Peter S., Asaithamby, Aroumougame, Shah, Ajay M., Szweda, Luke I., Sadek, Hesham A.

“…The mammalian heart has a remarkable regenerative capacity for a short period of time after birth, after which the majority of cardiomyocytes permanently exit…”
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The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment by Chen, Rui, Xu, Min, Nagati, Jason S, Hogg, Richard T, Das, Alok, Gerard, Robert D, Garcia, Joseph A

“…Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine…”
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Rare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis by Zhang, David, Povysil, Gundula, Kobeissy, Philippe H, Li, Qi, Wang, Binhan, Amelotte, Mason, Jaouadi, Hager, Newton, Chad A, Maher, Toby M, Molyneaux, Philip L, Noth, Imre, Martinez, Fernando J, Raghu, Ganesh, Todd, Jamie L, Palmer, Scott M, Haefliger, Carolina, Platt, Adam, Petrovski, Slavé, Garcia, Joseph A, Goldstein, David B, Garcia, Christine Kim

“…Genetic studies of idiopathic pulmonary fibrosis (IPF) have improved our understanding of this disease, but not all causal loci have been identified. To…”
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Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis by Garcia, Joseph A, Chen, Rui, Xu, Min, Comerford, Sarah A, Hammer, Robert E, Melton, Shelby D, Feagins, Linda A

“…The microenvironment of solid tumors is characterized by oxygen and glucose deprivation. Acss2/HIF-2 signaling coordinates essential genetic regulators…”
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Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia by Wang, Benjamin, Peng, Ying-Jie, Su, Xiaoyu, Zhang, Chongxu, Nagati, Jason S, Garcia, Joseph A, Prabhakar, Nanduri R

“…Olfactory receptor (Olfr) 78 is expressed in the carotid bodies (CB) and participates in CB responses to acute hypoxia. Olfr78 is also expressed in the kidney,…”
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Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia by Shohet, Ralph V, Garcia, Joseph A

“…Myocardial ischemia, the most common cause of cardiac hypoxia in clinical medicine, occurs when oxygen delivery cannot meet myocardial metabolic requirements…”
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A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling by Nagati, Jason S, Xu, Min, Garcia, Trent, Comerford, Sarah A, Hammer, Robert E, Garcia, Joseph A

“…The response to environmental stresses by eukaryotic organisms includes activation of protective biological mechanisms, orchestrated in part by transcriptional…”
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Intermittent hypoxia degrades HIF-2α via calpains resulting in oxidative stress: Implications for recurrent apnea-induced morbidities by Nanduri, Jayasri, Wang, Ning, Yuan, Guoxiang, Khan, Shakil A, Souvannakitti, Dangjai, Peng, Ying-Jie, Kumar, Ganesh K, Garcia, Joseph A, Prabhakar, Nanduri R

“…Intermittent hypoxia (IH) occurs in many pathological conditions including recurrent apneas. Hypoxia-inducible factors (HIFs) 1 and 2 mediate transcriptional…”
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Diagnostic Yield of Newborn Screening for Biliary Atresia Using Direct or Conjugated Bilirubin Measurements by Harpavat, Sanjiv, Garcia-Prats, Joseph A, Anaya, Carlos, Brandt, Mary L, Lupo, Philip J, Finegold, Milton J, Obuobi, Alice, ElHennawy, Adel A, Jarriel, William S, Shneider, Benjamin L

“…IMPORTANCE: Treating biliary atresia in newborns earlier can delay or prevent the need for liver transplant; however, treatment typically occurs later because…”
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Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis by Yuan, Guoxiang, Peng, Ying-Jie, Reddy, Vaddi Damodara, Makarenko, Vladislav V, Nanduri, Jayasri, Khan, Shakil A, Garcia, Joseph A, Kumar, Ganesh K, Semenza, Gregg L, Prabhakar, Nanduri R

“…Breathing and blood pressure are under constant homeostatic regulation to maintain optimal oxygen delivery to the tissues. Chemosensory reflexes initiated by…”
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Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension by Peng, Ying-Jie, Nanduri, Jayasri, Khan, Shakil A, Yuan, Guoxiang, Wang, Ning, Kinsman, Brian, Vaddi, Damodara R, Kumar, Ganesh K, Garcia, Joseph A, Semenza, Gregg L, Prabhakar, Nanduri R

“…Cardiorespiratory functions in mammals are exquisitely sensitive to changes in arterial O₂ levels. Hypoxia-inducible factors (e.g., HIF-1 and HIF-2) mediate…”
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An acetate switch regulates stress erythropoiesis by Xu, Min, Nagati, Jason S, Xie, Jian, Li, Jiwen, Walters, Holly, Moon, Young-Ah, Gerard, Robert D, Huang, Chou-Long, Comerford, Sarah A, Hammer, Robert E, Horton, Jay D, Chen, Rui, Garcia, Joseph A

“…Manipulation of acetate levels in mice can affect the activity of the hypoxia-responsive transcription factor HIF-2α and facilitate recovery from anemia. The…”
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Targeted Access to the Genomes of Low-Abundance Organisms in Complex Microbial Communities by PODAR, Mircea, ABULENCIA, Carl B, WALCHER, Marion, HUTCHISON, Don, ZENGLER, Karsten, GARCIA, Joseph A, HOLLAND, Trevin, COTTON, David, HAUSER, Loren, KELLER, Martin

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Newborn Bilirubin Screening for Biliary Atresia by Harpavat, Sanjiv, Garcia-Prats, Joseph A, Shneider, Benjamin L

“…In this preliminary study at four hospitals, newborn screening for biliary atresia with a two-stage measurement of serum bilirubin levels had very high…”
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Pyrocinchonimides Conjugate to Amine Groups on Proteins via Imide Transfer by Richardson, Mark B, Gabriel, Kristin N, Garcia, Joseph A, Ashby, Shareen N, Dyer, Rebekah P, Kim, Joshua K, Lau, Calvin J, Hong, John, Le Tourneau, Ryan J, Sen, Sanjana, Narel, David L, Katz, Benjamin B, Ziller, Joseph W, Majumdar, Sudipta, Collins, Philip G, Weiss, Gregory A

“…Advances in bioconjugation, the ability to link biomolecules to each other, small molecules, surfaces, and more, can spur the development of advanced materials…”
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NPAS2: An Analog of Clock Operative in the Mammalian Forebrain by Reick, Martin, Garcia, Joseph A., Dudley, Carol, McKnight, Steven L.

“…Neuronal PAS domain protein 2 (NPAS2) is a transcription factor expressed primarily in the mammalian forebrain. NPAS2 is highly related in primary amino acid…”
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Environmental Whole-Genome Amplification To Access Microbial Populations in Contaminated Sediments by ABULENCIA, Carl B, WYBORSKI, Denise L, KELLER, Martin, GARCIA, Joseph A, PODAR, Mircea, WENQIONG CHEN, CHANG, Sherman H, CHANG, Hwai W, WATSON, David, BRODIE, Eoin L, HAZEN, Terry C

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1 −/− mice by Garcia, Joseph A, Scortegagna, Marzia, Ding, Kan, Oktay, Yavuz, Gaur, Arti, Thurmond, Frederick, Yan, Liang-Jun, Marck, Brett T, Matsumoto, Alvin M, Shelton, John M, Richardson, James A, Bennett, Michael J

“…Hypoxia-inducible factor (HIF) transcription factors respond to multiple environmental stressors, including hypoxia and hypoglycemia. We report that mice…”
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Transcriptional Regulation During Development of the Ductus Arteriosus by Ivey, Kathryn N, Sutcliffe, David, Richardson, James, Clyman, Ronald I, Garcia, Joseph A, Srivastava, Deepak

“…The ductus arteriosus is a specialized blood vessel containing highly differentiated and contractile vascular smooth muscle, derived largely from neural crest…”
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