Search Results - "García Vence, María"
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Proteomic Analysis in Morquio A Cells Treated with Immobilized Enzymatic Replacement Therapy on Nanostructured Lipid Systems
Published in International journal of molecular sciences (18-09-2019)“…Morquio A syndrome, or mucopolysaccharidosis type IVA (MPS IVA), is a lysosomal storage disease due to mutations in the N-acetylgalactosamine-6-sulfatase ( )…”
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Impact of liver-specific GLUT8 silencing on fructose-induced inflammation and omega oxidation
Published in iScience (19-02-2021)“…Excessive consumption of high-fructose diets is associated with insulin resistance, obesity, and non-alcoholic fatty liver disease (NAFLD). However, fructose…”
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Potential clinical applications of the personalized, disease-specific protein corona on nanoparticles
Published in Clinica chimica acta (01-02-2020)“…[Display omitted] •Surfaces of nanomaterials are covered by proteins to form a protein corona (PC).•PC modifies the physicochemical properties of…”
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SWATH-MS Protocols in Human Diseases
Published in Methods in molecular biology (Clifton, N.J.) (2021)“…Identification of molecular biomarkers for human diseases is one of the most important disciplines in translational science as it helps to elucidate their…”
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Protein Extraction From FFPE Kidney Tissue Samples: A Review of the Literature and Characterization of Techniques
Published in Frontiers in medicine (13-05-2021)“…Most tissue biopsies from patients in hospital environments are formalin-fixed and paraffin-embedded (FFPE) for long-term storage. This fixation process…”
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Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level
Published in Journal of biosciences (01-12-2016)“…Two-pore channels (TPCs or TPCNs) are novel voltage-gated ion channels that have been postulated to act as Ca 2+ and/or Na + channels expressed exclusively in…”
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Protein Corona Gold Nanoparticles Fingerprinting Reveals a Profile of Blood Coagulation Proteins in the Serum of HER2-Overexpressing Breast Cancer Patients
Published in International journal of molecular sciences (10-11-2020)“…Breast cancer (BC) is a molecularly heterogeneous disease that encompasses five major molecular subtypes (luminal A (LA), luminal B HER2 negative (LB-),…”
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Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases
Published in Disease markers (01-01-2018)“…The Global Burden of Oral Diseases affects 3.5 billion people worldwide, representing the number of people affected by the burden of untreated dental caries,…”
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A Novel Nanoproteomic Approach for the Identification of Molecular Targets Associated with Thyroid Tumors
Published in Nanomaterials (Basel, Switzerland) (28-11-2020)“…A thyroid nodule is the most common presentation of thyroid cancer; thus, it is extremely important to differentiate benign from malignant nodules. Within…”
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Identification of a Profile of Neutrophil-Derived Granule Proteins in the Surface of Gold Nanoparticles after Their Interaction with Human Breast Cancer Sera
Published in Nanomaterials (Basel, Switzerland) (23-06-2020)“…It is well known that the interaction of a nanomaterial with a biological fluid leads to the formation of a protein corona (PC) surrounding the nanomaterial…”
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Proteomic investigation on bio-corona of Au, Ag and Fe nanoparticles for the discovery of triple negative breast cancer serum protein biomarkers
Published in Journal of proteomics (10-02-2020)“…Nowadays, there are no targeted therapeutic modalities for triple negative breast cancer (TNBC). This disease is associated with poor prognosis and worst…”
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Proteomic analysis of extracellular vesicles derived from platelet concentrates treated with Mirasol® identifies biomarkers of platelet storage lesion
Published in Journal of proteomics (06-01-2020)“…In blood banks, platelets are stored until 7 days after a pathogen reduction technology (PRT) treatment, Mirasol® (vitamin B2 plus UVB light) in the present…”
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Identification of proteomic biomarkers in proliferative verrucous leukoplakia through LC-MS/MS
Published in Laboratory investigation (26-07-2023)“…Proliferative verrucous leukoplakia (PVL) is an oral potentially malignant disorder (OPMD) associated with high risk of malignant transformation. Currently,…”
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Identification of Proteomic Biomarkers in Proliferative Verrucous Leukoplakia through Liquid Chromatography With Tandem Mass Spectrometry
Published in Laboratory investigation (01-10-2023)“…Proliferative verrucous leukoplakia (PVL) is an oral potentially malignant disorder associated with high risk of malignant transformation. Currently, there is…”
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Inhibition of hepatic p63 ameliorates steatohepatitis with fibrosis in mice
Published in Molecular metabolism (Germany) (01-07-2024)“…p63 is a transcription factor involved in multiple biological functions. In the liver, the TAp63 isoform induces lipid accumulation in hepatocytes. However,…”
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Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions
Published in Channels (Austin, Tex.) (02-01-2017)“…Two-pore channels (TPC1-3) comprise a subfamily of the eukaryotic voltage-gated ion channels (VGICs) superfamily that are mainly expressed in acidic stores in…”
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Morquio syndrome type A treatment with non-viral vector
Published in Molecular genetics and metabolism (01-02-2020)Get full text
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O-GlcNAcylated p53 in the liver modulates hepatic glucose production
Published in Nature communications (20-08-2021)“…p53 regulates several signaling pathways to maintain the metabolic homeostasis of cells and modulates the cellular response to stress. Deficiency or excess of…”
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Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function
Published in Journal of hepatology (01-01-2022)“…Autophagy-related gene 3 (ATG3) is an enzyme mainly known for its actions in the LC3 lipidation process, which is essential for autophagy. Whether ATG3 plays a…”
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p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway
Published in Cell reports. Medicine (20-02-2024)“…The p63 protein has pleiotropic functions and, in the liver, participates in the progression of nonalcoholic fatty liver disease (NAFLD). However, its…”
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