Search Results - "García Marco, José A."

Matrix Metalloproteinase-9 Promotes Chronic Lymphocytic Leukemia B Cell Survival through Its Hemopexin Domain by Redondo-Muñoz, Javier, Ugarte-Berzal, Estefanía, Terol, María José, Van den Steen, Philippe E., Hernández del Cerro, Mercedes, Roderfeld, Martin, Roeb, Elke, Opdenakker, Ghislain, García-Marco, José A., García-Pardo, Angeles

“…Matrix metalloproteinase-9 (MMP-9) is the major MMP produced by B-CLL cells and contributes to their tissue infiltration by degrading extracellular and…”
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HLA‐partially matched cellular therapy (stem‐cell microtransplantation) for acute myeloid leukaemia: description of four cases by Forés, Rafael, Dorado, Nieves, Vilches, Carlos, Regidor, Carmen, García‐Marco, José A., Pablo, Rosario, Laiglesia, Almudena, Lario, Ana, Piris, Miguel, Cabrera, J. Rafael

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Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine and arsenic trioxide by Amigo-Jiménez, Irene, Bailón, Elvira, Ugarte-Berzal, Estefanía, Aguilera-Montilla, Noemí, García-Marco, José A, García-Pardo, Angeles

“…Matrix metalloproteinase-9 (MMP-9) contributes to chronic lymphocytic leukemia (CLL) pathology by regulating cell migration and preventing spontaneous…”
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New mutations in chronic lymphocytic leukemia identified by target enrichment and deep sequencing by Doménech, Elena, Gómez-López, Gonzalo, Gzlez-Peña, Daniel, López, Mar, Herreros, Beatriz, Menezes, Juliane, Gómez-Lozano, Natalia, Carro, Angel, Graña, Osvaldo, Pisano, David G, Domínguez, Orlando, García-Marco, José A, Piris, Miguel A, Sánchez-Beato, Margarita

“…Chronic lymphocytic leukemia (CLL) is a heterogeneous disease without a well-defined genetic alteration responsible for the onset of the disease. Several lines…”
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Arsenic trioxide synergistically potentiates the cytotoxic effect of fludarabine in chronic lymphocytic leukemia cells by further inactivating the Akt and ERK signaling pathways by Lozano-Santos, Carol, Amigo-Jiménez, Irene, Nova-Gurumeta, Sara, Pérez-Sanz, Nuria, García-Pardo, Angeles, García-Marco, José A.

“…CLL remains an incurable disease, making it crucial to continue searching for new therapies efficient in all CLL cases. We have studied the effect of combining…”
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Overexpression of progelatinase B/proMMP‐9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen by Bailón, Elvira, Ugarte‐Berzal, Estefanía, Amigo‐Jiménez, Irene, Van den Steen, Philippe, Opdenakker, Ghislain, García‐Marco, José A., García‐Pardo, Angeles

“…Elevated (pro)MMP‐9 expression alters key regulatory molecules (ERK, FAK, RhoAGTPase, PTEN) and impairs CLL cell migration, favoring organ retention and…”
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Results of a pilot study on the use of third-party donor mesenchymal stromal cells in cord blood transplantation in adults by Gonzalo-Daganzo, Rosa, Regidor, Carmen, Martín-Donaire, Trinidad, Rico, Miguel Angel, Bautista, Guiomar, Krsnik, Isabel, Forés, Rafael, Ojeda, Emilio, Sanjuán, Isabel, García-Marco, José A, Navarro, Belén, Gil, Santiago, Sánchez, Rocío, Panadero, Nuria, Gutiérrez, Yolanda, García-Berciano, Miguel, Pérez, Nuria, Millán, Isabel, Cabrera, Rafael, Fernández, Manuel N

“…Background aims Cord blood (CB) transplants with co-infusion of third-party donor (TPD) mobilized hematopoietic stem cells (MHSC) have been shown to result in…”
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Chronic lymphocytic leukemia cells in lymph nodes show frequent NOTCH1 activation by Onaindia, Arantza, Gómez, Sagrario, Piris-Villaespesa, Miguel, Martínez-Laperche, Carolina, Cereceda, Laura, Montes-Moreno, Santiago, Batlle, Ana, de Villambrosia, Sonia González, Pollán, Marina, Martín-Acosta, Paloma, González-Rincón, Julia, Menarguez, Javier, Alvés, Javier, Rodriguez-Pinilla, Socorro M, García, Juan F, Mollejo, Manuela, Fraga, Máximo, García-Marco, José A, Piris, Miguel A, Sánchez-Beato, Margarita

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Autologous stem cell transplantation after conditioning with yttrium-90 ibritumomab tiuxetan plus BEAM in refractory non-Hodgkin diffuse large B-cell lymphoma: results of a prospective, multicenter, phase II clinical trial by Briones, Javier, Novelli, Silvana, García-Marco, José A, Tomás, José F, Bernal, Teresa, Grande, Carlos, Canales, Miguel A, Torres, Antonio, Moraleda, José M, Panizo, Carlos, Jarque, Isidro, Palmero, Francisca, Hernández, Miguel, González-Barca, Eva, López, Dulce, Caballero, Dolores

“…Lymphoma patients with persistent disease undergoing autologous transplantation have a very poor prognosis in the rituximab era. The addition of…”
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PLCG1 mutations in cutaneous T-cell lymphomas by Vaqué, José P., Gómez-López, Gonzalo, Monsálvez, Verónica, Varela, Ignacio, Martínez, Nerea, Pérez, Cristina, Domínguez, Orlando, Graña, Osvaldo, Rodríguez-Peralto, José L., Rodríguez-Pinilla, Socorro M., González-Vela, Carmen, Rubio-Camarillo, Miriam, Martín-Sánchez, Esperanza, Pisano, David G., Papadavid, Evangelia, Papadaki, Theodora, Requena, Luis, García-Marco, José A., Méndez, Miriam, Provencio, Mariano, Hospital, Mercedes, Suárez-Massa, Dolores, Postigo, Concepción, San Segundo, David, López-Hoyos, Marcos, Ortiz-Romero, Pablo L., Piris, Miguel A., Sánchez-Beato, Margarita

“…Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of primary cutaneous T-cell lymphoproliferative processes, mainly composed of mycosis fungoides and…”
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Autologous stem cell transplantation after conditioning with yttrium-90 ibritumomab tiuxetan BEAM in refractory non-Hodgkin diffuse large B-cell lymphoma: results of a prospective, multicenter, phase II clinical trial by Briones, Javier, Novelli, Silvana, García-Marco, José A, Tomás, José F, Bernal, Teresa, Grande, Carlos, Canales, Miguel A, Torres, Antonio, Moraleda, José M, Panizo, Carlos, Jarque, Isidro, Palmero, Francisca, Hernández, Miguel, González-Barca, Eva, López, Dulce, Caballero, Dolores

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MMP-9 affects gene expression in chronic lymphocytic leukemia revealing CD99 as an MMP-9 target and a novel partner in malignant cell migration/arrest by Aguilera-Montilla, Noemí, Bailón, Elvira, Uceda-Castro, Rebeca, Ugarte-Berzal, Estefanía, Santos, Andrea, Gutiérrez-González, Alejandra, Pérez-Sánchez, Cristina, Van den Steen, Philippe E., Opdenakker, Ghislain, García-Marco, José A., García-Pardo, Angeles

“…We previously showed that MMP-9 contributes to CLL pathology by regulating cell survival and migration and that, when present at high levels, MMP-9 induces…”
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Matrix metalloproteinase-9 induces a pro-angiogenic profile in chronic lymphocytic leukemia cells by Aguilera-Montilla, Noemí, Bailón, Elvira, Ugarte-Berzal, Estefanía, Uceda-Castro, Rebeca, Prieto-Solano, María, García-Martínez, Elena, Samaniego, Rafael, Van den Steen, Philippe E., Opdenakker, Ghislain, García-Marco, José A., García-Pardo, Angeles

“…Increased angiogenesis is commonly observed in chronic lymphocytic leukemia (CLL) tissues in correlation with advanced disease. CLL cells express pro- and…”
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A Novel CD44-binding Peptide from the Pro-Matrix Metalloproteinase-9 Hemopexin Domain Impairs Adhesion and Migration of Chronic Lymphocytic Leukemia (CLL) Cells by Ugarte-Berzal, Estefanía, Bailón, Elvira, Amigo-Jiménez, Irene, Albar, Juan Pablo, García-Marco, José A., García-Pardo, Angeles

“…(pro)MMP-9 binds to CLL cells through the PEX9 domain and contributes to CLL progression. To biochemically characterize this interaction and identify potential…”
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Genomic mutation profile in progressive chronic lymphocytic leukemia patients prior to first-line chemoimmunotherapy with FCR and rituximab maintenance (REM) by González-Rincón, Julia, Garcia-Vela, José A, Gómez, Sagrario, Fernández-Cuevas, Belén, Nova-Gurumeta, Sara, Pérez-Sanz, Nuria, Alcoceba, Miguel, González, Marcos, Anguita, Eduardo, López-Jiménez, Javier, González-Barca, Eva, Yáñez, Lucrecia, Pérez-Persona, Ernesto, de la Serna, Javier, Fernández-Zarzoso, Miguel, Deben, Guillermo, Peñalver, Francisco J, Fernández, María C, de Oteyza, Jaime Pérez, Andreu, M Ángeles, Ruíz-Guinaldo, M Ángeles, Paz-Arias, Raquel, García-Malo, M Dolores, Recasens, Valle, Collado, Rosa, Córdoba, Raúl, Navarro-Matilla, Belén, Sánchez-Beato, Margarita, García-Marco, José A

“…Chronic Lymphocytic Leukemia (CLL) is the most prevalent leukemia in Western countries and is notable for its variable clinical course. This variability is…”
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A catalytically inactive gelatinase B/MMP-9 mutant impairs homing of chronic lymphocytic leukemia cells by altering migration regulatory pathways by Bailón, Elvira, Aguilera-Montilla, Noemí, Gutiérrez-González, Alejandra, Ugarte-Berzal, Estefanía, Van den Steen, Philippe E., Opdenakker, Ghislain, García-Marco, José A., García-Pardo, Angeles

“…We previously showed that MMP-9 overexpression impairs migration of primary CLL cells and MEC-1 cells transfected with MMP-9. To determine the contribution of…”
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Clonal dynamics monitoring during clinical evolution in chronic lymphocytic leukaemia by González-Rincón, Julia, Gómez, Sagrario, Martinez, Nerea, Troulé, Kevin, Perales-Patón, Javier, Derdak, Sophia, Beltrán, Sergi, Fernández-Cuevas, Belén, Pérez-Sanz, Nuria, Nova-Gurumeta, Sara, Gut, Ivo, Al-Shahrour, Fátima, Piris, Miguel A., García-Marco, José A., Sánchez-Beato, Margarita

“…Chronic lymphocytic leukaemia is the most prevalent leukaemia in Western countries. It is an incurable disease characterized by a highly variable clinical…”
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High prognostic value of measurable residual disease detection by flow cytometry in chronic lymphocytic leukemia patients treated with front-line fludarabine, cyclophosphamide, and rituximab, followed by three years of rituximab maintenance by García-Marco, José A, Jiménez, Javier López, Recasens, Valle, Zarzoso, Miguel Fernández, González-Barca, Eva, De Marcos, Nieves Somolinos, Ramírez, M Jose, Parraga, Francisco Javier Peñalver, Yañez, Lucrecia, De La Serna Torroba, Javier, Malo, Maria Dolores Garcia, Ariznavarreta, Guillermo Deben, Persona, Ernesto Perez, Guinaldo, M Angeles Ruiz, De Paz Arias, Raquel, Llanos, Elena Bañas, Jarque, Isidro, Valle, M Del Carmen Fernandez, Tatay, Ana Carral, De Oteyza, Jaime Perez, Martin, Eva Maria Donato, Fernández, Inmaculada Perez, Martinez, Rafael Martinez, Costa, M Angeles Andreu, Champ, Diana, Suarez, Julio García, Díaz, Marcos González, Ferrer, Secundino, Carbonell, Félix, García-Vela, José A

“…It has been postulated that monitoring measurable residual disease (MRD) could be used as a surrogate marker of progression-free survival (PFS) in chronic…”
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Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9 by Amigo-Jiménez, Irene, Bailón, Elvira, Aguilera-Montilla, Noemí, García-Marco, José A, García-Pardo, Angeles

“…CLL remains an incurable disease in spite of the many new compounds being tested. Arsenic trioxide (ATO) induces apoptosis in all CLL cell types and could…”
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Drug induction apoptosis assay as predictive value of chemotherapy response in patients with B-cell chronic lymphocytic leukemia by Castejón, Raquel, Yebra, Miguel, Citores, María-Jesús, Villarreal, Mercedes, García-Marco, José A., Vargas, Juan A.

“…A large number of prognostic factors are available to help predict the course of the disease for patients with B-cell chronic lymphocytic leukemia (B-CLL)…”
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